Gordon D. Brown
University of Exeter
C-type lectinPattern recognition receptorInnate immune systemPhagocytosisReceptorChemistryAcquired immune systemImmunologyInflammationMacrophageImmunityCandida albicansSykBiochemistrySignal transductionMedicineBiologyImmune systemMicrobiologyCell biology
Publications 317
#1Fabián Salazar (University of Exeter)
#2Elaine Bignell (University of Exeter)H-Index: 29
Last. Adilia Warris (University of Exeter)H-Index: 49
view all 5 authors...
Individuals suffering from severe viral respiratory tract infections have recently emerged as "at risk" groups for developing invasive fungal infections. Influenza virus is one of the most common causes of acute lower respiratory tract infections worldwide. Fungal infections complicating influenza pneumonia are associated with increased disease severity and mortality, with invasive pulmonary aspergillosis being the most common manifestation. Strikingly, similar observations have been made during...
#1Gabriela W. P. Neves (UERJ: Rio de Janeiro State University)H-Index: 6
#2Sarah Sze Wah Wong (Pasteur Institute)H-Index: 11
Last. Gordon D. Brown (University of Exeter)H-Index: 108
view all 11 authors...
In this study, the human immune response mechanisms against Sporothrix brasiliensis and Sporothrix schenckii, two causative agents of human and animal sporotrichosis, were investigated. The interaction of S. brasiliensis and S. schenckii with human monocyte-derived macrophages (hMDM) was shown to be dependent on the thermolabile serum complement protein C3, which facilitated the phagocytosis of Sporothrix yeast cells through opsonization. The peptidorhamnomannan (PRM) component of the cell walls...
The ability to discriminate indolent from clinically significant prostate cancer (PC) at the initial biopsy remains a challenge. The ExoDx Prostate (IntelliScore) (EPI) test is a noninvasive liquid biopsy that quantifies three RNA targets in urine exosomes. The EPI test stratifies patients for risk of high-grade prostate cancer (HGPC; ≥ Grade Group 2 [GG] PC) in men ≥ 50 years with equivocal prostate-specific antigen (PSA) (2–10 ng/mL). Here, we present a pooled meta-analysis from three independ...
#1Gordon D. BrownH-Index: 108
#2Jason AlterH-Index: 4
Last. Grannum R. SantH-Index: 47
view all 9 authors...
#1Anirban P. MitraH-Index: 29
#2Vikram M. NarayanH-Index: 12
Last. Jeffrey S. MontgomeryH-Index: 33
view all 43 authors...
INTRODUCTION AND OBJECTIVE:Nadofaragene firadenovec is a recombinant adenoviral vector-based intravesical therapeutic that delivers a copy of human IFNα2b gene to urothelial cells. A recent phase 3...
#2Gordon D. BrownH-Index: 108
Last. Neal D. ShoreH-Index: 58
view all 10 authors...
Our data reveal that selection of enzymes for generating single cell suspensions from murine tissues influences detection of surface expression of antifungal CLRs. Using a method that most preserves receptor expression, we show that non-myeloid expression of antifungal CLRs is limited to MelLec on endothelial cells in murine mucosal tissues.
#4Ivy M. Dambuza (University of Exeter)H-Index: 16
#6Carol Wallace (University of Exeter)H-Index: 11
Environmental factors, particularly fungi, influence the pathogenesis of allergic airway inflammation, but the mechanisms underlying these effects are still unclear. Melanin is one fungal component which is thought to modulate pulmonary inflammation. We recently identified a novel C-type lectin receptor, MelLec (Clec1a), which recognizes fungal 1,8-dihydroxynaphthalene (DHN)-melanin and is able to regulate inflammatory responses. Here we show that MelLec promotes pulmonary allergic inflammation ...
#8Matteo Zanda (Aberd.: University of Aberdeen)H-Index: 24
We describe the chemical synthesis of the fungal naphthopyrones YWA1 and fonsecin B, as well as their functionalization with an amine-spacer arm and the conjugation of the resulting molecules to three different functional tags (i.e., biotin, Oregon green, 1-[3-(succinimidyloxycarbonyl)benzyl]-4-[5-(4-methoxyphenyl)-2-oxazolyl]pyridinium bromide (PyMPO)). The naphthopyrone-biotin and -PyMPO constructs maintained the ability to bind the C-type lectin receptor MelLec, whose interaction with immunol...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.