Kazuhiko Mori
Daiichi Sankyo
HistamineQT intervalInternal medicineEndocrinologyPathologymicroRNAMolecular biologyInotropeEndoplasmic reticulumCardiologyChemistryIn vitroIn vivoVentricular pressureKidneyToxicityAntibacterial agentMedicineBiologyPharmacology
54Publications
9H-index
314Citations
Publications 59
Newest
#1Kazuyoshi Kumagai (Daiichi Sankyo)H-Index: 7
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
view all 6 authors...
Trastuzumab deruxtecan (T-DXd: DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) Ab-drug conjugated with deruxtecan (DXd), a derivative of exatecan. The objective of this study was to characterize T-DXd-induced lung toxicity in cynomolgus monkeys. Trastuzumab deruxtecan was injected i.v. into monkeys once every 3 weeks for 6 weeks (10, 30, and 78.8 mg/kg) or for 3 months (3, 10, and 30 mg/kg). To evaluate the involvement of DXd alone in T-DXd-induced toxicity, DXd monohydrate ...
2 CitationsSource
#1Eri Hamamura-Yasuno (Daiichi Sankyo)H-Index: 1
#2Takuma Iguchi (Daiichi Sankyo)H-Index: 5
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
view all 5 authors...
MAS-related G protein coupled receptor-X2 (MRGPRX2), expressed in human mast cells, is associated with drug-induced pseudo-allergic reactions. Dogs are highly susceptible to drug-induced anaphylactoid reactions caused by various drugs; however, the distribution and physiological function of canine MRGPR family genes, including MRGPRX2, remain largely unknown. In the present study, we clarified the distribution of dog MRGPR family genes by real-time quantitative PCR and in situ hybridisation. We ...
2 CitationsSource
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#1Kosuke SaitoH-Index: 12
#2Tatehiro Kagawa (Tokai University)H-Index: 16
Last. Hajime Takikawa (Teikyo University)H-Index: 33
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Drug-induced liver injury (DILI) is a major adverse event caused by drug treatment, which can be categorized into three types: hepatocellular, mixed, and cholestatic. Although nearly every class of drugs can cause DILI, an overall understanding of lipid profiles in DILI patients is lacking. We used lipidomics to analyze the plasma lipid profiles of patients to understand their hepatic pathophysiology and identify DILI biomarkers. We identified 463 lipids and compared their levels between the acu...
3 CitationsSource
#1Ayako Sayama (Daiichi Sankyo)H-Index: 5
#2Keiko Okado (Daiichi Sankyo)H-Index: 2
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
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Mer proto-oncogene tyrosine kinase (MerTK), expressed in the retinal pigment epithelium (RPE), regulates the phagocytosis of shed photoreceptor outer segments. To investigate the influence of dosin...
1 CitationsSource
#1Kyohei Yasuno (Daiichi Sankyo)H-Index: 1
#2Eri Hamamura-Yasuno (Daiichi Sankyo)H-Index: 1
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
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INTRODUCTION: Host cell proteins (HCPs) are contaminated proteins remaining after purification of biopharmaceuticals. Recent reports revealed clinical implications of HCPs in anti-drug antibody (ADA) development in patients without any inflammatory effects. Therefore, we evaluated the inflammatory effects and immunogenicity of HCPs in an in vivo study by intravitreal administration to rabbits and an in vitro THP-1 cells assay. METHODS: Escherichia coli-derived HCPs at 200 ng/eye with or without ...
2 CitationsSource
#1Katsuyoshi Chiba (Daiichi Sankyo)H-Index: 8
#2Tomomichi Ishizaka (Daiichi Sankyo)H-Index: 4
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
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Abstract The objective of this study was to elucidate the underlying cardiotoxic mechanism of milrinone, a cAMP phosphodiesterase 3 inhibitor, by evaluating cardiac functions, blood biomarkers including cardiac troponin I (cTnI), microRNAs (miR-1, miR-133a and miR-499a) and various endogenous metabolites, and histopathology in conscious cynomolgus monkeys. Milrinone at doses of 0, 3 and 30 mg/kg were orally administered to monkeys (n = 3–4/group), and the endpoints were evaluated 1 to 24 h post-...
1 CitationsSource
#1Eri Hamamura-Yasuno (Daiichi Sankyo)H-Index: 1
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
view all 4 authors...
Injection site reaction (ISR) is a common side-effect associated with the use of peptide or protein pharmaceuticals. These types of pharmaceuticals-induced activation of antigen-presenting cells is assumed to be a key step in the pathogenesis of immune-mediated ISR. The present study was designed to evaluate the immunostimulatory properties of peptide or protein pharmaceuticals using human monocytic THP-1 cells. Here, THP-1 cells, with or without phorbol-12-myristate-13-acetate (PMA) pretreatmen...
1 CitationsSource
#1Takuma Iguchi (Daiichi Sankyo)H-Index: 5
#2Koichi Goto (Daiichi Sankyo)H-Index: 1
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
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Abstract Dysglycemia is one of the most serious adverse events associated with the clinical use of certain fluoroquinolones. The purpose of this study was to investigate the effects of the representative fluoroquinolones moxifloxacin and gatifloxacin on hepatic gluconeogenesis using primary monkey hepatocytes. Glucose production was induced after the cells were incubated for 4 h with 10 mM sodium lactate and 1 mM sodium pyruvate as gluconeogenic substrates. Under these conditions, moxifloxacin a...
1 CitationsSource
#1Hiroya Konno (Daiichi Sankyo)
#2Tomomichi Ishizaka (Daiichi Sankyo)H-Index: 4
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
view all 4 authors...
Measurement of the renal resistive index (RRI) is one of the standard diagnostic procedures for assessing kidney disability clinically. This method is expected to be used for the same purpose in many kinds of animals, including monkeys utilized in conventional toxicology studies. To establish a practical RRI measurement procedure in cynomolgus monkeys (Macaca fascicularis), RRI was measured by ultrasonography in the spine position in conscious and ketamine-immobilized monkeys. The RRI of conscio...
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