Marie-A. Chaix
Montreal Heart Institute
Intraclass correlationInduced pluripotent stem cellRisk assessmentInternal medicineEtiologyFunction (biology)SurgeryMutantMagnetic resonance imagingEmbryonic stem cellPsychosocialOdds ratioCohen's kappaCardiologyExome sequencingSystoleIntensive care medicinePhysical therapyProspective cohort studyMassive parallel sequencingSudden cardiac deathGreat arteriesCardiac imagingSurvival rateVentricular tachycardiaPalpitationsAtrial switchImplantable cardioverter-defibrillatorDeconditioningVascular diseaseIngenuityCoronary artery diseaseSarcomadextro-Transposition of the great arteriesTetralogy of FallotChest painSedentary lifestyleVentricleDiseaseComorbidityEisenmenger syndromeMalignancyAutopsyLong QT syndromeContext (language use)Heart diseasePulmonary hypertensionPulmonary arteryPopulationPostcapillary pulmonary hypertensionVentricle outflow tractTransplantationCoronary atherosclerosisLate onsetSudden deathPalliative careSurgical therapyIn patientPoor prognosisVentricular sizeConfidence intervalTransposition (music)Myocardial infarctionMutationObesityGeneticsDiastoleVascular resistanceBioinformaticsComputational biologyMedicineComplicationBiology
12Publications
7H-index
118Citations
Publications 11
Newest
#1Emmanuelle Massie (MHI: Montreal Heart Institute)H-Index: 1
#2Michel White (MHI: Montreal Heart Institute)H-Index: 39
Last. Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 7
view all 7 authors...
Abstract Primary pulmonary artery sarcoma is an exceedingly rare and aggressive malignancy that carries poor prognosis. Clinical manifestations are nonspecific and include chest pain, dyspnea, syncope, palpitations, and asthenia, among others. Delay to diagnosis is common and compromises the prognosis. Here, we report an interesting case of primary pulmonary artery sarcoma presenting with frequent monomorphic premature ventricular contractions arising from the right/left ventricle outflow tract....
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#1Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 7
#2Michael A. Gatzoulis (NIH: National Institutes of Health)H-Index: 90
Last. Erwin Oechslin (UHN: University Health Network)H-Index: 58
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Abstract Eisenmenger syndrome is the most severe and extreme phenotype of pulmonary arterial hypertension associated with congenital heart disease. A large non-restrictive systemic left-to-right shunt triggers the development of pulmonary vascular disease, progressive pulmonary arterial hypertension and increasing pulmonary vascular resistance at the systemic level, which ultimately results in shunt reversal. Herein, we review the changing epidemiological patterns and pathophysiology of Eisenmen...
8 CitationsSource
#2François Simard (MHI: Montreal Heart Institute)H-Index: 2
Last. François-Pierre Mongeon (MHI: Montreal Heart Institute)H-Index: 17
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#1Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 7
#2May Chergui (UdeM: Université de Montréal)H-Index: 1
Last. Paul Khairy (MHI: Montreal Heart Institute)H-Index: 70
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Abstract Background Sudden death is the leading cause of mortality in patients with transposition of the great arteries (TGA) and atrial switch surgery. Understanding underlying mechanisms could contribute to identifying high-risk patients and preventing such catastrophic deaths. Methods A total of 144 adults (≥18 years) with TGA and atrial switch surgery were followed at our adult congenital center since 1989. Four patients were excluded: two with double-outlet right ventricles and two with sub...
6 CitationsSource
#1Marie-A. ChaixH-Index: 7
#2Paul Khairy (MHI: Montreal Heart Institute)H-Index: 70
Dextro-transposition of the great arteries (D-TGA), whether isolated (simple) or associated with other congenital cardiac lesions (complex), is prevalent in 0.2 per 1,000 live births and accounts for 5% to 7% of congenital heart defects (1,2). Management of D-TGA epitomizes the remarkable strides achieved in medical and surgical therapy over time in the broader field of congenital heart disease. From the original palliative Blalock-Hanlon septectomy to the modern-day arterial switch operation (A...
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#1Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 7
#2Annie Dore (MHI: Montreal Heart Institute)H-Index: 27
Last. François-Pierre Mongeon (MHI: Montreal Heart Institute)H-Index: 17
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Abstract Background Echocardiographic evaluation of the systemic right ventricle (sRV) remains challenging in patients with transposition of the great arteries (TGA) corrected by an atrial switch (AS) and with congenitally corrected TGA (ccTGA). The aim of this study was to determine the interobserver and intraobserver variability of echocardiographic parameters for sRV size and systolic function. Methods Six independent observers retrospectively interpreted 44 previously acquired echocardiogram...
3 CitationsSource
#1Jean-Baptiste Gourraud (MHI: Montreal Heart Institute)H-Index: 19
#1Jean-Baptiste Gourraud (MHI: Montreal Heart Institute)H-Index: 3
Last. Blandine Mondésert (MHI: Montreal Heart Institute)H-Index: 16
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Background: Safety and feasibility data on transvenous lead extraction (TLE) in the challenging population of adults with congenital heart disease (A-CHD) are limited. Herein, we report the results of TLE in A-CHD during a 20-year period. Methods and Results: All consecutive TLE procedures in A-CHD were included in a monocentric prospective registry from 1996. A total of 121 leads were extracted in 49 A-CHD (median age, 38 years; 51% men) during 71 TLE procedures. Twenty-four (49%) patients had ...
9 CitationsSource
#1Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 7
#2Annie Dore (MHI: Montreal Heart Institute)H-Index: 27
Last. Paul Khairy (MHI: Montreal Heart Institute)H-Index: 70
view all 12 authors...
BackgroundThere is a paucity of data regarding late‐onset pulmonary hypertension (PH) in patients with transposition of the great arteries and atrial switch surgery. Methods and ResultsA retrospect...
10 CitationsSource
#1Roselle Gélinas (MHI: Montreal Heart Institute)H-Index: 12
#2Nabil El Khoury (MHI: Montreal Heart Institute)H-Index: 2
Last. John D. Rioux (MHI: Montreal Heart Institute)H-Index: 93
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BACKGROUND: Long-QT syndrome is a potentially fatal condition for which 30% of patients are without a genetically confirmed diagnosis. Rapid identification of causal mutations is thus a priority to avoid at-risk situations that can lead to fatal cardiac events. Massively parallel sequencing technologies are useful for the identification of sequence variants; however, electrophysiological testing of newly identified variants is crucial to demonstrate causality. Long-QT syndrome could, therefore, ...
11 CitationsSource
#1Pablo Ávila (Complutense University of Madrid)H-Index: 11
#2Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 7
Last. Paul Khairy (MHI: Montreal Heart Institute)H-Index: 70
view all 4 authors...
: Sudden death of presumed arrhythmic etiology is a leading cause of mortality in adults with congenital heart disease. Anticipated benefits of the implantable cardioverter-defibrillator (ICD) must be weighed against high complication rates. Without robust evidence from randomized trials, caregivers face difficult decisions in selecting appropriate candidates. Although secondary prevention indications are often clear-cut, risk stratification for primary prevention ICDs is more challenging. Facto...
12 CitationsSource