Yi Man
Sichuan University
OsseointegrationBiophysicsBiomedical engineeringCellRegeneration (biology)ChemistryMaterials scienceMesenchymal stem cellDentistryIn vivoBarrier membraneBiocompatibilityMacrophageDental implantImplantBone regenerationMembraneChemical engineeringMedicineCell biology
95Publications
19H-index
1,061Citations
Publications 91
Newest
#1Shue Jin (Sichuan University)H-Index: 5
#2Renli Yang (Sichuan University)H-Index: 2
Last. Jidong Li (Sichuan University)H-Index: 18
view all 9 authors...
The fate of biomaterials is orchestrated by biocompatibility and bioregulation characteristics, reported to be closely related to topographical structures. For the purpose to investigate the topography of fibrous membranes on the guided bone regeneration performance, we successfully fabricated poly (lactate-co-glycolate)/fish collagen/nano-hydroxyapatite (PFCH) fibrous membranes with random, aligned and latticed topography by electrospinning. The physical, chemical and biological properties of t...
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#1Chen Hu (Sichuan University)H-Index: 4
#2Chenyu Chu (Sichuan University)H-Index: 3
Last. Yi Man (Sichuan University)H-Index: 19
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The structural properties of biomaterials play crucial roles in guiding cell behavior and influencing immune responses against the material. We fabricated electrospun membranes with three types of surface topography (random, aligned, and latticed), introduced them to dorsal skin excisional wounds in mice and rats, and evaluated their effects on wound healing and immunomodulatory properties. An overview of different immune cells in the microenvironment with the help of single-cell RNA sequencing ...
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#1Chenyu Chu (Sichuan University)H-Index: 3
#2Shengan Rung (Sichuan University)H-Index: 3
Last. Yi Man (Sichuan University)H-Index: 19
view all 5 authors...
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#1Congrong WangH-Index: 27
#1Chenbing Wang (Sichuan University)H-Index: 1
Last. Yi ManH-Index: 19
view all 8 authors...
The re-epithelialization with appendages is a major challenge to skin injury. Given that topographical factors initially modulate cell activities, the design of biomaterials with the topography (such as pattern and diameter) offers a promising strategy for achieving optimal skin wound healing. Herein, we prepare an aligned fish collagen reinforced poly (lactide-co-glycolide) electrospinning membrane (FC/PLGA) with different fiber diameters for promoting the re-epithelialization with appendages. ...
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#1Xiyu Li (Sichuan University)H-Index: 4
#2Juan Wu (Sichuan University)H-Index: 2
Last. Wei Li (Sichuan University)H-Index: 55
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Abstract Insufficient early osteogenesis seriously affects the later stage osteogenic quality and osseointegration of dental implants. To promote early osteogenesis, we first designed a Ti dental implant with a built-in magnet (mTi) to produce a local static magnetic field (SMF). Then, a dental implantation system comprising the mTi implant and the superparamagnetic hydroxyapatite (HA:Yb/Ho–Fe, named HYH-Fe) particles was implanted into the alveolar bone of beagles. The results showed that the m...
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#1Wenlan Xiao (Sichuan University)H-Index: 1
#2Yaqian Chen (Sichuan University)H-Index: 1
Last. Yi Man (Sichuan University)H-Index: 19
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Abstract Statement of problem Titanium-zirconium (Ti-Zr) alloy (Roxolid) narrow-diameter implants (NDIs) have been widely used for implant-supported prostheses in anterior and posterior regions in the jaws. However, the relationship between implant location and clinical outcome remains unclear. Purpose The purpose of this clinical study was to evaluate and compare the clinical and radiographic outcomes of NDIs placed in different regions of the jaws in both smokers and nonsmokers. Material and m...
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#1Chenyu Chu (Sichuan University)H-Index: 3
#2Shengan Rung (Sichuan University)H-Index: 3
Last. Yi Man (Sichuan University)H-Index: 19
view all 5 authors...
Culturing macrophage in vitro is an important means to understand its reaction towards co-culture substances. However, the source of macrophages can be either purchased from specific cell line or extracted from bone marrow as differentiated macrophages. In order to assure the precision, when adopting extracted primary cell, screening in advance will be prominent before any processes to avoid results reserving that of non-macrophages. Here, we perform single-cell sequencing on open wound of skin ...
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#1Chenyu ChuH-Index: 3
#2Shengan Rung (Sichuan University)H-Index: 3
Last. Yili QuH-Index: 16
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Abstract Though chemically cross-linked by EDC/NHS endows collagen membrane with promising mechanical properties, it is not conducive to modulation of foreign body reaction (FBR) after implantation or guidance of osteogenesis. In our previous research, we have found that macrophages have a strong regulatory effect on tissue and bone regeneration during FBR, and EGCG modified membranes could adjust the recruitment and phenotypes of macrophages. Accordingly, we develop the EGCG-EDC/NHS membranes, ...
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#1Chenyu ChuH-Index: 3
#2Shengan RungH-Index: 3
Last. Yi ManH-Index: 19
view all 6 authors...
Culturing macrophage in vitro is an important means to understand its reaction towards co-culture substances. However, the source of macrophages can be either purchased from specific cell line or extracted from bone marrow as differentiated macrophages. In order to assure the precision, when adopting extracted primary cell, screening in advance will be prominent before any processes to avoid results reserving that of non-macrophages. Here, we perform single-cell sequencing on open wound of skin ...
Source
#1Chen Hu (Sichuan University)H-Index: 4
#2Chenyu Chu (Sichuan University)H-Index: 3
Last. Jidong Li (Sichuan University)H-Index: 18
view all 5 authors...
Structural properties of biomaterials play critical roles in guiding cell behaviors and influence the immune response against them. In this study, we fabricated electro-spun membranes with three types of surface topography (Random, Aligned, and Latticed). The aligned membranes showed immunomodulatory ability, and led to faster wound healing, reduced fibrotic response and enhanced regeneration of cutaneous appendages. Based on that, we performed single-cell RNA sequencing analysis on cells of wou...
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