Yuliya Klymenko
Indiana University
CancerInternal medicineOncologyCellCadherinAdipose tissueChemistryExtracellular matrixMesenchymal stem cellPeritoneumTumor microenvironmentLysophosphatidic acidPeritoneal cavityMetastasisMechanobiologyPrimary tumorOvarian cancerAscitesMesothelial CellCancer researchMedicineBiologyCancer cell
Publications 19
#1Karen A. Bailey (ND: University of Notre Dame)H-Index: 2
#2Yuliya Klymenko (ND: University of Notre Dame)H-Index: 8
Last. Zachary D. Schultz (ND: University of Notre Dame)H-Index: 22
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Ovarian cancer (OvCa) cells are reported to undergo biochemical changes at the cell surface in response to treatment with lysophosphatidic acid (LPA). Here we use scanning electron microscopy (SEM) and multiplex coherent anti-Stokes Raman scattering (CARS) imaging via supercontinuum excitation to probe morphological changes that result from LPA treatment. SEM images show distinct shedding of microvilli-like features upon treatment with LPA. Analysis of multiplex CARS images can distinguish betwe...
6 CitationsSource
#1Yuliya Klymenko (ND: University of Notre Dame)H-Index: 8
#2Oleg Kim (UCR: University of California, Riverside)H-Index: 18
Last. M. Stack (ND: University of Notre Dame)H-Index: 2
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Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis
32 CitationsSource
#1Yuliya Klymenko (IU: Indiana University)
#1Yuliya Klymenko (IU: Indiana University)H-Index: 8
Last. M. Stack (ND: University of Notre Dame)H-Index: 2
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Unlike most epithelial malignancies which metastasize hematogenously, metastasis of epithelial ovarian cancer (EOC) occurs primarily via transcoelomic dissemination, characterized by exfoliation of cells from the primary tumor, avoidance of detachment-induced cell death (anoikis), movement throughout the peritoneal cavity as individual cells and multi-cellular aggregates (MCAs), adhesion to and disruption of the mesothelial lining of the peritoneum, and submesothelial matrix anchoring and prolif...
40 CitationsSource
#1Yuliya Klymenko (ND: University of Notre Dame)H-Index: 8
#2Jeffrey J. Johnson (ND: University of Notre Dame)H-Index: 17
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
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Abstract Epithelial ovarian carcinoma spreads via shedding of cells and multicellular aggregates (MCAs) from the primary tumor into peritoneal cavity, with subsequent intraperitoneal tumor cell:mesothelial cell adhesion as a key early event in metastatic seeding. Evaluation of human tumor extracts and tissues confirms that well-differentiated ovarian tumors express abundant E-cadherin (Ecad), whereas advanced lesions exhibit upregulated N-cadherin (Ncad). Two expression patterns are observed: "m...
32 CitationsSource
Ovarian cancer (OvCa) is the leading gynecological malignancy in women in the United States. OvCa metastasizes uniquely, spreading through the peritoneal cavity and generating widespread metastatic sites. The vast majority of OvCa cases occur in women over 40 and the median age at diagnosis is 63 (SEER). Despite age being a significant risk factor for the development of OvCa, there is a paucity of studies addressing the role of aging in OvCa metastasis. To our knowledge, there are no reports uti...
Ovarian cancer is the most lethal gynecological cancer in U.S. women. Poor 5-year survival rates ( 90%. Metastasizing tumor cells grow rapidly and aggressively attach to the mesothelium of all organs within the peritoneal cavity, including the parietal peritoneum and the omentum, producing secondary lesions. Mesothelin (MSLN), a 40kDa glycoprotein that is over expressed in many cancers including ovarian and mesotheliomas is suggested to play a role in cell survival, proliferation, tumor progress...
#1Elizabeth Loughran (ND: University of Notre Dame)H-Index: 7
#2Ryan Phan (ND: University of Notre Dame)
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
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Ovarian cancer is the most fatal gynecological cancer. Epithelial ovarian cancer (OvCa), the most common subtype, usually goes undetected until metastatic and often fatal stages of the disease. OvCa follows a unique form of metastasis, spreading through the peritoneal cavity and forming metastatic sites on the peritoneum. Epidemiologic data suggest that child-bearing, or parity, reduces a woman9s risk of developing ovarian cancer, with more births providing greater protection. Despite the associ...
#1Yueying Liu (ND: University of Notre Dame)H-Index: 16
#2Matthew N. Metzinger (ND: University of Notre Dame)H-Index: 3
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
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Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy, with high mortality attributable to widespread intraperitoneal metastases. Recent meta-analyses report an association between obesity, ovarian cancer incidence, and ovarian cancer survival, but the effect of obesity on metastasis has not been evaluated. The objective of this study was to use an integrative approach combining in vitro , ex vivo , and in vivo studies to test the hypothesis that obesity contr...
48 CitationsSource
#1Yuliya Klymenko (ND: University of Notre Dame)H-Index: 8
#2M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
Epithelial Ovarian Carcinoma (EOC) is the fifth leading cause of women's cancer-related death and deadliest of all gynecological cancers with 22,240 new and 14,230 fatal cases predicted in 2013 ( American Cancer Society Estimates, 2013 ), primarily due to detection at late metastatic, prognostically poor stages of the disease. As opposed to other malignancies, EOC metastasis occurs by shedding of cancer cells from the primary tumor directly into the peritoneal cavity where they form multicellula...
1 CitationsSource