William A E Parker
University of Sheffield
Internal medicineSurgeryCardiologyAntithromboticPrasugrelAspirinAcute coronary syndromeClopidogrelCoronary artery diseaseMEDLINEPercutaneous coronary interventionThrombosisTicagrelorRegimenPlatelet activationConventional PCIP2Y12Myocardial infarctionMedicinePlateletPharmacology
44Publications
8H-index
236Citations
Publications 44
Newest
#1Nicholas C. Sanderson (University of Sheffield)
#2William A E Parker (University of Sheffield)H-Index: 8
Last. Robert F. Storey (University of Sheffield)H-Index: 90
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Platelets participate centrally in atherothrombosis, resulting in vessel occlusion and ischaemia. Consequently, optimisation of antiplatelet regimens has the potential to further reduce the residual burden of morbidity and mortality associated with atherosclerosis. Ticagrelor is a potent oral platelet P2Y12 receptor antagonist that (1) inhibits a central amplification pathway of platelet activation directly as well as via an active metabolite, (2) has a rapid onset and offset of antiplatelet act...
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#1Michela Giustozzi (University of Perugia)H-Index: 12
#2Hanne Ehrlinder (KI: Karolinska Institutet)H-Index: 1
Last. William A E Parker (University of Sheffield)H-Index: 8
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Abstract null null Sepsis is a complex syndrome with a high incidence, increasing by 8.7% annually over the last 20 years. Coagulopathy is a leading factor associated with mortality in patients with sepsis and range from slight thrombocytopenia to fatal disorders, such as disseminated intravascular coagulation (DIC). Platelet reactivity increases during sepsis but prospective trials of antiplatelet therapy during sepsis have been disappointing. Thrombocytopenia is a known predictor of worse prog...
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#1Thomas A Nelson (University of Sheffield)
#2William A E Parker (University of Sheffield)H-Index: 8
Last. Robert F. Storey (University of Sheffield)H-Index: 90
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Inflammation plays a key role in cardiovascular disease by contributing to atherothrombosis. The PLATelet inhibition and patient Outcomes (PLATO) study (NCT00391872) compared ticagrelor to clopidogrel in patients with acute coronary syndromes and demonstrated fewer cardiovascular events with ticagrelor but lower white blood cell counts (WBC) with clopidogrel. In this further analysis of the PLATO biomarker substudy, we assessed associations between WBC and clinical characteristics, biomarker lev...
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#1William A E Parker (University of Sheffield)H-Index: 8
#2Robert F. Storey (University of Sheffield)H-Index: 90
### Learning objectives Globally, much morbidity and premature mortality arises from coronary artery disease (CAD). Coronary artery atherothrombosis is the dominant cause of acute coronary syndromes (ACS), including spontaneous myocardial infarction (MI) and unstable angina. Those with chronic coronary syndromes (CCS), including stable CAD or an ACS event >1 year ago, are at ongoing atherothrombotic risk.1 Modifiable or partially modifiable risk factors such as hypercholesterolaemia, diabetes me...
1 CitationsSource
#1Aleksandra Gąsecka (Medical University of Warsaw)H-Index: 5
#1Aleksandra Gasecka (Medical University of Warsaw)H-Index: 9
Last. Gemma Chiva-BlanchH-Index: 30
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Introduction Emerging evidence points to an association between severe clinical presentation of COVID-19 and increased risk of thromboembolism. One-third of patients hospitalized due to severe COVID-19 develops macrovascular thrombotic complications, including venous thromboembolism, myocardial injury/infarction and stroke. Concurrently, the autopsy series indicate multiorgan damage pattern consistent with microvascular injury. Prophylaxis, diagnosis and treatment COVID-19 associated coagulopath...
17 CitationsSource
1 CitationsSource
#1Victoria L. Parker (University of Sheffield)H-Index: 3
#2Matthew C WinterH-Index: 14
Last. Robert F. HarrisonH-Index: 26
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BACKGROUND The International Federation of Gynaecology and Obstetrics (FIGO) score identifies gestational trophoblastic neoplasia (GTN) patients as low- or high-risk of single-agent chemotherapy resistance (SACR). Computed tomography (CT) has greater sensitivity than chest X-ray (CXR) in detecting pulmonary metastases, but effects upon outcomes remain unclear. METHODS Five hundred and eighty-nine patients underwent both CXR and CT during GTN assessment. Treatment decisions were CXR based. The nu...
1 CitationsSource
#1P. Papakonstantinou (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Josip Anđelo Borovac (University of Split)H-Index: 10
Last. Rui Azevedo GuerreiroH-Index: 4
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#1William A E Parker (University of Sheffield)H-Index: 8
#2Robert F. Storey (University of Sheffield)H-Index: 90
AbstractAspirin and P2Y12 inhibitors remain commonly prescribed antiplatelet drugs in the treatment of atherothrombotic conditions. Despite established benefits of dual antiplatelet therapy (DAPT) ...
6 CitationsSource
#1Barry Hennigan (Golden Jubilee National Hospital)H-Index: 9
#2Richard Good (Golden Jubilee National Hospital)H-Index: 10
Last. Keith G. Oldroyd (Golden Jubilee National Hospital)H-Index: 52
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Cessation of one component of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has been associated with increased risk of ischemic events but it is uncertain whether discontinuation of aspirin is preferable to discontinuation of the oral P2Y12 inhibitor. The GLOBAL LEADERS study compared two antiplatelet strategies following PCI, cessation of aspirin at 1 month with continued ticagrelor monotherapy for 23 months versus standard DAPT for 12 months followed by as...
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