Eric Courchesne
University of California, San Diego
AnatomyDevelopmental psychologyMagnetic resonance imagingPsychologyNeuroscienceCognitionCognitive psychologyAutismAutism spectrum disorderDevelopmental disorderFunctional magnetic resonance imagingCerebellumWhite matterBrain mappingAbnormalityElectroencephalographyGeneticsAudiologyMedicineBiology
241Publications
116H-index
36kCitations
Publications 231
Newest
#1William M. Brandler (UCSD: University of California, San Diego)H-Index: 12
#2Danny AntakiH-Index: 10
Last. Jonathan Sebat (UCSD: University of California, San Diego)H-Index: 47
view all 35 authors...
Genetic studies of autism spectrum disorder (ASD) have established that de novo duplications and deletions contribute to risk. However, ascertainment of structural variants (SVs) has been restricted by the coarse resolution of current approaches. By applying a custom pipeline for SV discovery, genotyping, and de novo assembly to genome sequencing of 235 subjects (71 affected individuals, 26 healthy siblings, and their parents), we compiled an atlas of 29,719 SV loci (5,213/genome), comprising 11...
56 CitationsSource
#1Tiziano Pramparo (UCSD: University of California, San Diego)H-Index: 31
#2Michael V. Lombardo (University of Cambridge)H-Index: 56
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 15 authors...
Genetic mechanisms underlying abnormal early neural development in toddlers with Autism Spectrum Disorder (ASD) remain uncertain due to the impossibility of direct brain gene expression measurement during critical periods of early development. Recent findings from a multi-tissue study demonstrated high expression of many of the same gene networks between blood and brain tissues, in particular with cell cycle functions. We explored relationships between blood gene expression and total brain volum...
53 CitationsSource
#1Michael V. Lombardo (University of Cambridge)H-Index: 56
#2Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 8 authors...
SUMMARY Autism (ASD) is vastly heterogeneous, particularly in early language development. While ASD language trajectories in thefirst years of life arehighly unstable, by early childhood these trajectories stabilize and are predictive of longer-term outcome. Early neural substrates that predict/precede such outcomes are largely unknown, but could have considerable translational and clinical impact. Pre-diagnosis fMRI response to speech in ASD toddlers with relatively good language outcome was hi...
110 CitationsSource
#1Tiziano Pramparo (UCSD: University of California, San Diego)H-Index: 31
#2Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 10 authors...
Importance The identification of genomic signatures that aid early identification of individuals at risk for autism spectrum disorder (ASD) in the toddler period remains a major challenge because of the genetic and phenotypic heterogeneity of the disorder. Generally, ASD is not diagnosed before the fourth to fifth birthday. Objective To apply a functional genomic approach to identify a biologically relevant signature with promising performance in the diagnostic classification of infants and todd...
65 CitationsSource
#1Rich Martin Stoner (UCSD: University of California, San Diego)H-Index: 2
#2Maggie Chow (Allen Institute for Brain Science)H-Index: 9
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 10 authors...
Background Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development. Methods To systematically examine neocortical architecture during the early years after the onset of autism, we used RNA in situ hybridization with...
431 CitationsSource
#1Elizabeth Bacon (UCSD: University of California, San Diego)H-Index: 6
#2Sarah Dufek (UCSD: University of California, San Diego)H-Index: 6
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 6 authors...
Measuring progress of children with autism spectrum disorder (ASD) during intervention programs is a challenge faced by researchers and clinicians. Typically, standardized assessments of child development are used within research settings to measure the effects of early intervention programs. However, the use of standardized assessments is not without limitations, including lack of sensitivity of some assessments to measure small or slow progress, testing constraints that may affect the child's ...
21 CitationsSource
#1Janessa H. Manning (University of Texas Health Science Center at San Antonio)H-Index: 7
#2Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
Last. Peter T. FoxH-Index: 143
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Abstract Structural and functional neuroimaging have substantively informed the pathophysiology of numerous adult neurological and psychiatric disorders. While structural neuroimaging is readily acquired in sedated young children, pediatric application of functional neuroimaging has been limited by the behavioral demands of in-scanner task performance. Here, we investigated whether functional magnetic resonance imaging (fMRI) acquired during natural sleep and without experimental stimulation off...
14 CitationsSource
#1Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
#2Peter R. Mouton (USF: University of South Florida)H-Index: 34
Last. Katarina Semendeferi (UCSD: University of California, San Diego)H-Index: 1
view all 8 authors...
3 CitationsSource
#1Stephen J. Glatt (SUNY: State University of New York System)H-Index: 53
#2Ming T. Tsuang (UCSD: University of California, San Diego)H-Index: 165
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 11 authors...
Objective Autism spectrum disorders (ASDs) are highly heritable neurodevelopmental disorders that onset clinically during the first years of life. ASD risk biomarkers expressed early in life could significantly impact diagnosis and treatment, but no transcriptome-wide biomarker classifiers derived from fresh blood samples from children with autism have yet emerged. Method Using a community-based, prospective, longitudinal method, we identified 60 infants and toddlers at risk for ASDs (autistic d...
74 CitationsSource
#1John T. Morgan (UCSD: University of California, San Diego)H-Index: 4
#2Gursharan Chana (UCSD: University of California, San Diego)H-Index: 22
Last. Ian P. Everall (UCSD: University of California, San Diego)H-Index: 65
view all 6 authors...
Abstract Microglial activation and alterations in neuron number have been reported in autism. However, it is unknown whether microglial activation in the disorder includes a neuron-directed microglial response that might reflect neuronal dysfunction, or instead indicates a non-directed, pro-activation brain environment. To address this question, we examined microglial and neuronal organization in the dorsolateral prefrontal cortex, a region of pronounced early brain overgrowth in autism, via spa...
135 CitationsSource