Michael J. Wannemuehler
Iowa State University
BiophysicsAntigenMolecular biologyVirologyAntibodyChemistryMaterials scienceImmunologyColitisInflammationColonizationAltered Schaedler floraAdjuvantLipopolysaccharidePolyanhydridesBiochemistryAntigen-presenting cellMedicineBiologyImmune systemMicrobiology
Publications 188
#1Luman Liu (Iowa State University)H-Index: 1
#2Michael J. Wannemuehler (Iowa State University)H-Index: 44
Last. Balaji Narasimhan (Iowa State University)H-Index: 50
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Abstract null null Cancer immunotherapy approaches that utilize or enhance patients’ inherent immunity have received extensive attention in the past decade. Biomaterial-based nanocarriers with tunable physicochemical properties offer significant promise in cancer immunotherapies. They can lower payload toxicity, provide sustained release of diverse payloads, and target specific disease site(s). Furthermore, nanocarrier-mediated immunotherapies can induce antigen-specific T lymphocytes, tissue-di...
#1Sean M. Kelly (Iowa State University)H-Index: 6
#2Kristina R. Larsen (Iowa State University)
Last. Balaji Narasimhan (Iowa State University)H-Index: 50
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Abstract null null Bacillus anthracis, the causative agent of anthrax, continues to be a prominent biological warfare and bioterrorism threat. Vaccination is likely to remain the most effective and user-friendly public health measure to counter this threat in the foreseeable future. The commercially available AVA BioThrax vaccine has a number of shortcomings where improvement would lead to a more practical and effective vaccine for use in the case of an exposure event. Identification of more eff...
#1Luman Liu (Iowa State University)H-Index: 1
#2Prakash Kshirsagar (UNMC: University of Nebraska Medical Center)H-Index: 8
Last. Balaji Narasimhan (Iowa State University)H-Index: 50
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Pancreatic cancer (PC) is one of the most lethal malignancies and represents an increasing and challenging threat, especially with an aging population. The identification of immunogenic PC-specific upregulated antigens and an enhanced understanding of the immunosuppressive tumor microenvironment have provided opportunities to enable the immune system to recognize cancer cells. Due to its differential upregulation and functional role in PC, the transmembrane mucin MUC4 is an attractive target for...
6 CitationsSource
#1Zahra DavoudiH-Index: 7
Last. Qun WangH-Index: 50
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Intestinal organoids can be used as an ex vivo epithelial model to study different drug delivery effects on epithelial cells’ luminal surface. In this study, the impact of surface charge on the delivery of 5-ASA loaded PLGA nanoparticles into the lumen of organoids was investigated. Alginate and chitosan were used to coat the nanoparticles and provide negative and positive charges on the particles, respectively. The organoid growth and viability were not affected by the presence of either algina...
1 CitationsSource
#1Aleksandar KosticH-Index: 30
Last. Christophe BenoistH-Index: 144
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Multifunctional two-dimensional nanosheet materials have attracted attention in biomedical fields due to their unique physiochemical and biological properties. Interactions between intestinal stem cells and Engineered Nanomaterials (ENMs) are an essential area in research with the growing diagnosis of gastrointestinal (GI) diseases. One unique type of two-dimensional metal carbide nanomaterial, niobium carbide (Nb2 C), has shown promising properties for potential applications in this field, such...
#1Anne-Marie C. Overstreet (Iowa State University)H-Index: 5
#2Amanda E. Ramer-Tait (NU: University of Nebraska–Lincoln)H-Index: 29
Last. Michael J. Wannemuehler (Iowa State University)H-Index: 44
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The intestinal microbiota is a critical component of mucosal health as evidenced by the fact that alterations in the taxonomic composition of the gastrointestinal microbiota are associated with inflammatory bowel diseases. To better understand how the progression of inflammation impacts the composition of the gastrointestinal microbiota, we used culture independent taxonomic profiling to identify temporal changes in the cecal microbiota of C3Bir IL-10-/- mice concomitantly with the onset and pro...
#1Liping Sun (Iowa State University)H-Index: 1
#2Derrick K. Rollins (Iowa State University)H-Index: 15
Last. Qun Wang (Iowa State University)H-Index: 50
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Abstract Cytokines are key factors affecting the fate of intestinal stem cells (ISCs) and effective reagents to manipulate ISCs for research purpose. Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It can induce apoptotic cell death and inflammation, and to inhibit tumorigenesis and viral replication. Additionally, TNFα has been shown to play a critical role in the pathogenesis of inflammatory bowel disease (IBD). It is therefore important to ide...
1 CitationsSource