Maroun Khoury
University of Los Andes
Cell therapyGene silencingInternal medicineBiomedical engineeringPathologyCellChemistryMesenchymal stem cellImmunologyMicrovesiclesArthritisRheumatoid arthritisAngiogenesisStem cellTransplantationCancer researchBioinformaticsMedicineBiologyCell biology
Publications 99
#1Aliosha I. Figueroa-Valdés (University of the Andes, Chile)
#2Catalina de la Fuente (University of the Andes, Chile)
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Cell therapy is witnessing a notable shift toward cell-free treatments based on paracrine factors through cell’s secretome use and in particular, small extracellular vesicles (sEV), that mimic the functional effect of the parental cells. While numerous sEV-based applications are currently in advanced preclinical stages, their promising translation depends on overcoming the manufacturing hurdles posed by the large-scale production of purified sEV. Unquestionably, the culture medium used with the ...
#1Luiza Rachel Pinheiro de Carvalho (NIST: National Institute of Standards and Technology)H-Index: 1
#1Luiza Rachel Pinheiro de Carvalho (UFRJ: Federal University of Rio de Janeiro)H-Index: 3
Last. Patricia R. M. RoccoH-Index: 55
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OBJECTIVES To ascertain whether systemic administration of mitochondria-rich fraction isolated from mesenchymal stromal cells would reduce lung, kidney, and liver injury in experimental sepsis. DESIGN Animal study. SETTING Laboratory investigation. SUBJECTS Sixty C57BL/6 male mice. INTERVENTIONS Sepsis was induced by cecal ligation and puncture; sham-operated animals were used as control. At 24 hours after surgery, cecal ligation and puncture and Sham animals were further randomized to receive s...
2 CitationsSource
#1Lrp Carvalho (UFRJ: Federal University of Rio de Janeiro)
#2Soraia C. Abreu (UFRJ: Federal University of Rio de Janeiro)H-Index: 20
Last. P.R.M. Rocco (UFRJ: Federal University of Rio de Janeiro)H-Index: 14
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Background Although mesenchymal stromal cells (MSC) administration has demonstrated beneficial effects in experimental sepsis, cell-free therapeutics based on biologically active products from MSCs have been proposed to circumvent inherent risks related to whole-cell transplantation. As mitochondria transfer has emerged as one of the key mechanisms by which MSCs induce therapeutic actions, we asked whether MSC-isolated mitochondria could reduce lung, kidney, and liver injury, thus improving surv...
#1Christian Jorgensen (University of Montpellier)H-Index: 92
#2Maroun Khoury (University of the Andes, Chile)H-Index: 29
Musculoskeletal stromal cells’ (MSC) metabolism impact cell differentiation as well as immune function. BM-MSCs show a preference for glycolysis during proliferation but shift to a more oxidative phosphorylation (OxPhos)-dependent metabolism during osteogenic and adipogenic differentiation. The MSC immunoregulatory function is achieved through rapid cell polarization and sustained production of immunoregulatory factors (including PGE2, HGF, IL1RA, IL6, IL8, IDO activity) in response to inflammat...
1 CitationsSource
#1Maroun Khoury (University of Los Andes)H-Index: 29
#2Laertis Ikonomou (SUNY: State University of New York System)H-Index: 15
Last. Daniel J. Weiss (UVM: University of Vermont)H-Index: 54
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The global COVID-19 pandemic has prompted urgent need for potential therapies for severe respiratory consequences resulting from coronavirus infection. New therapeutic agents that will attenuate ongoing inflammation and at the same time promote regeneration of injured lung epithelial cells are urgently needed. Cell-based therapies, primarily involving mesenchymal stromal cells (MSCs) and their derivatives, are currently investigated worldwide for SARS-CoV-2-induced lung diseases. A significant n...
2 CitationsSource
Last. Patricia Luz-CrawfordH-Index: 16
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Objectives: Mesenchymal Stem/Stromal Cells (MSC) are promising therapeutic tools for inflammatory diseases due to their potent immunoregulatory capacities. Their suppressive activity mainly depends on inflammatory cues that have been recently associated with changes in MSC bioenergetic status towards a glycolytic metabolism. However, the molecular mechanisms behind this metabolic reprogramming and its impact on MSC therapeutic properties have not been investigated. Methods: Human and murine-deri...
1 CitationsSource
#1Mónica Kurte (University of Los Andes)H-Index: 8
#2Ana María Vega-Letter (University of Los Andes)H-Index: 7
Last. Flavio Carrión (Universidad del Desarrollo)H-Index: 20
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Background Mesenchymal stem cells (MSCs) have been recognized for their regenerative and anti-inflammatory capacity which makes them very attractive to cell therapy, especially those ones to treat inflammatory and autoimmune disease. Two different immune-phenotypes have been described for MSCs depending on which Toll-like receptor (TLR) is activated. MSC1 is endowed with a pro-inflammatory phenotype following TLR4 activation with LPS. On the other hand, anti-inflammatory MSC2 is induced by the a...
5 CitationsSource
#1Rafael Contreras-López (French Institute of Health and Medical Research)H-Index: 4
#2Roberto Elizondo-Vega (UdeC: University of Concepción)H-Index: 12
Last. Farida Djouad (French Institute of Health and Medical Research)H-Index: 26
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Mesenchymal stem cell (MSC)-based therapy is being increasingly considered a powerful opportunity for several disorders based on MSC immunoregulatory properties. Nonetheless, MSC are versatile and plastic cells that require an efficient control of their features and functions for their optimal use in clinic. Recently, we have shown that PPARβ/δ is pivotal for MSC immunoregulatory and therapeutic functions. However, the role of PPARβ/δ on MSC metabolic activity and the relevance of PPARβ/δ metabo...
23 CitationsSource