Sebastian Schneeweiss
Brigham and Women's Hospital
StatisticsEpidemiologyInternal medicineSurgeryOdds ratioHealth careRandomized controlled trialIntensive care medicinePropensity score matchingEmergency medicineCohort studyHazard ratioPharmacoepidemiologyMedical prescriptionMEDLINEPopulationConfidence intervalMedicineCohortConfounding
585Publications
114H-index
29.6kCitations
Publications 575
Newest
#1Michael Fralick (U of T: University of Toronto)H-Index: 18
#2Sebastian Schneeweiss (Brigham and Women's Hospital)H-Index: 114
Last. Elisabetta Patorno (Brigham and Women's Hospital)H-Index: 29
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AIM To assess the effectiveness and safety of sodium-glucose cotransporter-2 (SGLT2) inhibitors in treatment-naive patients compared with metformin. PARTICIPANTS AND METHODS We conducted a cohort study of US adults with type 2 diabetes mellitus who had not filled a prescription for a diabetes medication in the preceding year. We then identified patients who newly filled a prescription for an SGLT2 inhibitor or metformin between 2013 and 2018. The primary outcome was a composite of heart failure,...
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#1Mustafa Hashmi (Brigham and Women's Hospital)
#2Jeremy A. RassenH-Index: 35
Last. Sebastian Schneeweiss (Harvard University)H-Index: 114
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Aim: Single-arm trials with external control arms (ECAs) have gained popularity in oncology. ECAs may consist of primary data from previous trials, electronic health records (EHRs) or aggregate data from the literature. We sought to provide a description of how such studies achieve similarity of patients, comparability of data quality and outcome assessment. Materials & methods: In a stratified convenience sample of 15 studies, five used primary data from trials as ECAs, five used secondary data...
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#1HoJin Shin (Harvard University)H-Index: 2
#2Sebastian Schneeweiss (Brigham and Women's Hospital)H-Index: 114
Last. Elisabetta Patorno (Brigham and Women's Hospital)H-Index: 29
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OBJECTIVE null We evaluated recent use trends and predictors of first-line antidiabetes treatment in patients with type 2 diabetes. null RESEARCH DESIGN AND METHODS null Using two large U.S. health insurance databases (Clinformatics and Medicare), we identified adult patients with type 2 diabetes who initiated antidiabetes treatment from 2013 through 2019. Quarterly trends in use of first-line antidiabetes treatment were plotted overall and stratified by cardiovascular disease (CVD). Multinomial...
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#1Rishi J. Desai (Brigham and Women's Hospital)H-Index: 28
#2Elisabetta Patorno (Brigham and Women's Hospital)H-Index: 29
Last. Sebastian Schneeweiss (Brigham and Women's Hospital)H-Index: 114
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OBJECTIVE To evaluate the effectiveness of angiotensin receptor-neprilysin inhibitor (ARNI) versus renin-angiotensin system (RAS) blockade alone in older adults with heart failure with reduced ejection fraction (HFrEF). METHODS We conducted a cohort study using US Medicare fee-for-service claims data (2014-2017). Patients with HFrEF ≥65 years were identified in two cohorts: (1) initiators of ARNI or RAS blockade alone (ACE inhibitor, ACEI; or angiotensin receptor blocker, ARB) and (2) switchers ...
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#1HoJin ShinH-Index: 2
#2Sebastian SchneeweissH-Index: 114
Last. Elisabetta PatornoH-Index: 29
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#1Elisabetta PatornoH-Index: 29
#2Helen TesfayeH-Index: 1
Last. Sebastian SchneeweissH-Index: 114
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#1Elisabetta PatornoH-Index: 29
#2Helen TesfayeH-Index: 1
Last. Sebastian SchneeweissH-Index: 114
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#1Maria C. Schneeweiss (Harvard University)H-Index: 4
#2Seoyoung C. Kim (Harvard University)H-Index: 41
Last. Sebastian Schneeweiss (Harvard University)H-Index: 114
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Importance Several studies have linked chronic inflammatory skin diseases (CISDs) with venous thromboembolism (VTE) in a range of data sources with mixed conclusions. Objective To examine the incidence of VTE in patients with vs without CISD. Design, setting, and participants A cohort study using commercial insurance claims data from a nationwide US health care database from January 1, 2004, through 2019 was conducted. A total of 158 123 patients with dermatologist-recorded psoriasis, atopic der...
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#1Julien Kirchgesner (Brigham and Women's Hospital)H-Index: 13
#2Rishi J. Desai (Brigham and Women's Hospital)H-Index: 28
Last. Sebastian Schneeweiss (Brigham and Women's Hospital)H-Index: 114
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Real-world evidence (RWE) on the effectiveness of treatments in Crohn's disease (CD) derived from clinical practice data will help fill many evidence gaps left by randomized controlled trials (RCTs). Emulating RCTs with healthcare database studies may calibrate RWE studies in CD. We aimed to emulate the SONIC trial on the effectiveness of infliximab in patients with CD using U.S. and French healthcare claims data. SONIC had shown improved remission with combination therapy (i.e., infliximab plus...
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