Maria Teresa Cruz
University of Coimbra
ChemistryImmunologyEssential oilAntioxidantDendritic cellAnti-inflammatoryFood scienceCancer researchNitric oxideViability assayBiochemistryTraditional medicineBotanySignal transductionMedicineBiologyImmune systemMicrobiologyCell biologyPharmacology
Publications 155
#1Maria Inês Rocha (UC: University of Coimbra)
#2Maria José Gonçalves (UC: University of Coimbra)H-Index: 30
Last. Artur Figueirinha (UC: University of Coimbra)H-Index: 12
view all 8 authors...
Abstract Ethnopharmacological relevance Artemisia campestris L. is widely used in traditional medicine for their anti-inflammatory, antirheumatic, antimicrobial and antioxidant properties. A. campestris subsp. maritima Arcang., a halophyte plant (“madorneira” or “erva-lombrigueira” in Portugal), is traditionally used for gastric disorders, rheumatism and hypertension. Aim of the study The present study aims to characterize the essential oil (EO) and the hydrodistillation residual water (HRW), a ...
#1Diva SilvaH-Index: 1
#2Marta FerreiraH-Index: 19
Last. Isabel AlmeidaH-Index: 23
view all 5 authors...
The use of calendula for its lenitive properties’ dates to the XII century. This plant contains several bioactive compounds, including terpenoids, terpenes, carotenoids, flavonoids and polyunsaturated fatty acids. Calendula flower extract is used in soothing cosmetics, such as after-sun, sensitive skin and eye contour products. The anti-inflammatory properties of this ingredient were demonstrated in an animal model, but the mechanism of action is poorly understood. Therefore, our work explored t...
#1Fernanda Lopes Conte (UNESP: Sao Paulo State University)H-Index: 3
#2Karina Basso Santiago (UNESP: Sao Paulo State University)H-Index: 7
Last. José Maurício Sforcin (UNESP: Sao Paulo State University)H-Index: 41
view all 10 authors...
Objectives Propolis is a bee-made product used for centuries due to its diverse biological properties, including its immunomodulatory action. This work aimed at investigating whether propolis may affect monocyte functions challenged with retinoic acid (RA), B subunit of Escherichia coli heat-labile enterotoxin (EtxB), human melanoma-associated antigen-1 (MAGE-1) and lipopolysaccharide (LPS). Methods Monocytes from healthy donors were treated with the stimuli separately or in the presence of prop...
#1Cláudia P. Passos (University of Aveiro)H-Index: 17
#2Rita Costa (University of Aveiro)H-Index: 4
Last. Manuel A. Coimbra (University of Aveiro)H-Index: 65
view all 6 authors...
Coffee brews have High Molecular Weight (HMW) compounds with described immunostimulatory activity, namely polysaccharides and melanoidins. Melanoidins are formed during roasting and are modified during brews technological processing. In addition, brews have Low Molecular Weight (LMW) compounds, namely free chlorogenic acids and caffeine, with well-known anti-inflammatory properties. However, this study shows that both espresso and instant coffee brews did not present immunostimulatory neither an...
#1Constança Oliveira (UC: University of Coimbra)
#2João Calmeiro (UC: University of Coimbra)H-Index: 3
Last. Maria Teresa Cruz (UC: University of Coimbra)H-Index: 31
view all 7 authors...
Abstract Pancreatic cancer (PC) is one of the deadliest cancers with a very short rate of survival and commonly without symptoms in its early stage. This absence of symptoms can lead to a late diagnosis associated with an advanced metastasis process, for which therapy is not effective. Although with extensive research in this field, the 5-year survival rate has not increased significantly. Notwithstanding, novel insights on risk factors, genetic mutations and molecular mechanisms pave the way fo...
#1João CalmeiroH-Index: 3
#2Luis MendesH-Index: 11
Last. Bruno Miguel NevesH-Index: 18
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Dendritic cell (DC)-based antitumor vaccines have proven to be a safe approach, but often fail to generate robust results between trials. Translation to the clinic has been hindered in part by the lack of standard operation procedures for vaccines production, namely the definition of optimal culture conditions during ex-vivo DC differentiation. Here we sought to compare the ability of three clinical grade serum-free media, DendriMACS, AIM-V, and X-VIVO 15, alongside with fetal bovine serum-suppl...
1 CitationsSource
#1João Calmeiro (UC: University of Coimbra)H-Index: 3
#2Mylène Carrascal (UC: University of Coimbra)H-Index: 2
Last. Bruno Miguel Neves (University of Aveiro)H-Index: 18
view all 8 authors...
In the last decade, immunotherapy led to a paradigm shift in the treatment of numerous malignancies. Alongside with monoclonal antibodies blocking programmed cell death receptor-1 (PD-1)/PD-L1 and cytotoxic T- lymphocyte antigen 4 (CTLA-4) immune checkpoints, cell-based approaches such as CAR-T cells and dendritic cell (DC) vaccines have strongly contributed to pushing forward this thrilling field. While initial strategies were mainly focused on monotherapeutic regimens, it is now consensual tha...
Alzheimer's disease (AD) is one of the most common forms of dementia in the elderly. Currently, there are over 50 million cases of dementia worldwide and it is expected that it will reach 136 million by 2050. AD is described as a neurodegenerative disease that gradually compromises memory and learning capacity. Patients often exhibit brain glucose hypometabolism and are more susceptible to develop type 2 diabetes or insulin resistance in comparison with age-matched controls. This suggests that t...
#1A. Pereira (UC: University of Coimbra)H-Index: 3
#2J. S. Oliveira (UC: University of Coimbra)H-Index: 8
Last. Maria Teresa Cruz (UC: University of Coimbra)H-Index: 31
view all 6 authors...
Bipolar disorder (BD) is a chronic and cyclic mental disorder, characterized by unusual mood swings between mania/hypomania and depression, raising concern in both scientific and medical communities due to its deleterious social and economic impact. Polypharmacy is the rule due to the partial effectiveness of available drugs. Disease course is often unremitting, resulting in frequent cognitive deficits over time. Despite all research efforts in identifying BD-associated molecular mechanisms, cur...
3 CitationsSource
#1Sónia Pedreiro (UC: University of Coimbra)
#2Sandrine da Ressurreição (Escola Superior Agrária de Coimbra)H-Index: 2
Last. Fernando Ramos (UC: University of Coimbra)H-Index: 22
view all 7 authors...
Crepis vesicaria subsp. taraxacifolia (Cv) of Asteraceae family is used as food and in traditional medicine. However there are no studies on its nutritional value, phenolic composition and biological activities. In the present work, a nutritional analysis of Cv leaves was performed and its phenolic content and biological properties evaluated. The nutritional profile was achieved by gas chromatography (GC). A 70% ethanolic extract was prepared and characterized by HLPC-PDA-ESI/MSn. The quantifica...