Dulce Elena Casarini
Federal University of São Paulo
Angiotensin II receptor type 1Internal medicineEndocrinologyCardiologyReceptorEnzymeChemistryRenin–angiotensin systemAngiotensin-converting enzymeOxidative stressBradykininUrineKidneyLosartanAngiotensin IIBiochemistryDiabetes mellitusMedicineUrinary systemBlood pressureBiologyPharmacology
324Publications
40H-index
4,124Citations
Publications 331
Newest
#1Ralmony de Alcantara Santos (UNIFESP: Federal University of São Paulo)H-Index: 4
#2Vinicius Guzzoni (UNIFESP: Federal University of São Paulo)
Last. Tatiana Sousa Cunha (UNIFESP: Federal University of São Paulo)H-Index: 15
view all 10 authors...
Abstract null null Aims null We aimed to determine whether resistance training (RT) regulates renal renin-angiotensin system (RAS) components and inflammatory mediators in diabetic rats. null null null Main methods null Male Wistar rats (3 months old) were randomly assigned into four groups: non-trained (NT), trained (T), non-trained + diabetes (NTD) and trained +diabetes (TD). Diabetes was induced by streptozotocin (50 mg/kg, Sigma Chemical Co., St. Louis, MO, USA), before RT protocol. Trained ...
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#1Patricia Sousa Dantas (UNIFESP: Federal University of São Paulo)H-Index: 3
#2Vinicius Guzzoni (UNIFESP: Federal University of São Paulo)
Last. Tatiana Sousa Cunha (UNIFESP: Federal University of São Paulo)H-Index: 15
view all 8 authors...
Abstract null null We aimed to investigate the effects of high doses of nandrolone decanoate and resistance training (RT) on the proteomic profile of the left ventricle (LV) of rats, using a label-free quantitative approach. Male rats were randomized into four groups: untrained vehicle (UTV), trained vehicle (TV), untrained nandrolone (UTN), and trained nandrolone (TN). Rats were familiarized with the exercise training protocol (jump exercise) for one week. Jump-exercise was performed five days ...
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#1M. D. Passadore (UNIFESP: Federal University of São Paulo)H-Index: 3
#2Nayara Azinheira Nobrega Cruz (UNIFESP: Federal University of São Paulo)
Last. Lilian Caroline Gonçalves de Oliveira (UNIFESP: Federal University of São Paulo)H-Index: 11
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#1Ana Paula de Oliveira Leite (Tulane University)H-Index: 3
#2Xiao C Li (Tulane University)
Last. Jia L. Zhuo (Tulane University)
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In the present study, we tested the hypothesis that there are significant sex differences in angiotensin II (Ang II)-induced hypertension and kidney injury using male and female wild-type and proximal tubule-specific AT1a receptor knockout mice (PT-Agtr1a-/-). Twelve groups (n=8-12 per group) of adult male and female wild-type and PT-Agtr1a-/- mice were infused with a pressor dose of Ang II via osmotic pump for 2 weeks (1.5 mg/kg/day, i.p.) and simultaneously treated with or without losartan (20...
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#1Nayara Azinheira Nobrega Cruz (UNIFESP: Federal University of São Paulo)
#2Danielle Stoll (UNIFESP: Federal University of São Paulo)H-Index: 1
Last. Mariane Bertagnolli (McGill University)H-Index: 15
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In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme (ACE) 2 (ACE2), the main receptor for SARS-CoV-2, in human placentas indicates that this organ can be vulnerable for viral infection during pregnancy. However, for this to happen, additional molecular processes are critical to allow viral entry in cells, its replication and disease manife...
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#1A. Saud (UNIFESP: Federal University of São Paulo)
#2Rafael da Silva Luiz (UNIFESP: Federal University of São Paulo)H-Index: 2
Last. Nestor Schor (UNIFESP: Federal University of São Paulo)H-Index: 38
view all 11 authors...
Abstract Chronic kidney disease (CKD) is defined by decreased glomerular filtration rate (GFR) or increased albumin excretion leading to renal injury. However, exercise training is an important non-pharmacological intervention that ameliorates and protects against Diabetes Mellitus, cardiovascular disease, and CKD. Aim Our aim was to evaluate the capability of resistance exercise training (RET) to improve CKD outcomes and the contribution of the renal and muscular Akt/mTOR signaling pathway for ...
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#1Roseli Peres Moreira (UNIFESP: Federal University of São Paulo)H-Index: 3
#2Nadia S C Bertoncello (UNIFESP: Federal University of São Paulo)H-Index: 1
Last. Dulce Elena Casarini (UNIFESP: Federal University of São Paulo)H-Index: 40
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INTRODUCTION According to the International Diabetes Federation, the number of people with diabetes mellitus may reach 700 million in 2045. Catecholamines are involved in the regulation of several kidney functions. This study investigates the effects of hyperglycemia on catecholamines' metabolism in kidney tissue from control, diabetic, and insulin-treated diabetic rats, both in vivo and in vitro. METHODS Male Wistar-Hannover rats were randomized into: control, diabetic, and insulin-treated diab...
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#1Ho Chi Hsien (UNIFESP: Federal University of São Paulo)H-Index: 1
#2Dulce Elena Casarini (UNIFESP: Federal University of São Paulo)H-Index: 40
Last. Josefina Aparecida Pellegrini Braga (UNIFESP: Federal University of São Paulo)H-Index: 17
view all 6 authors...
INTRODUCTION Sickle cell nephropathy begins in childhood and presents early increases in glomerular filtration, which, over the long term, can lead to chronic renal failure. Several diseases have increased circulating and urinary angiotensin-converting enzyme (ACE) activity, but there is little information about changes in ACEs activity in children with sickle cell disease (SCD). OBJECTIVE We examined circulating and urinary ACE 1 activity in children with SCD. METHODS This cross-sectional study...
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