Takaharu Nomura
Central Research Institute of Electric Power Industry
IrradiationInternal medicineEndocrinologyMolecular biologyRadiochemistryEnzymeChemistryApoptosisSuperoxide dismutaseOxidative stressAntioxidantGlutathione peroxidaseCatalaseLipid peroxideLow dose rateLow doseGlutathioneBiochemistryCarcinogenesisMedicineBiologyCell biologyPharmacology
52Publications
19H-index
1,008Citations
Publications 55
Newest
#1Tetsuya Nakada (RMIT: RMIT University)H-Index: 1
#2Takahiro Kataoka (RMIT: RMIT University)H-Index: 16
Last. Kiyonori Yamaoka (RMIT: RMIT University)H-Index: 28
view all 8 authors...
The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower...
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#1Shota NaoeH-Index: 1
#2Takahiro KataokaH-Index: 16
Last. Kiyonori YamaokaH-Index: 28
view all 10 authors...
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#1Takahiro Kataoka (RMIT: RMIT University)H-Index: 16
#2Hina Shuto (RMIT: RMIT University)H-Index: 1
Last. Kiyonori Yamaoka (RMIT: RMIT University)H-Index: 28
view all 10 authors...
The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if ...
2 CitationsSource
#1Yukihiro Furusawa (University of Toyama)H-Index: 20
#2Qing-Li Zhao (University of Toyama)H-Index: 31
Last. Takashi Kondo (University of Toyama)H-Index: 52
view all 7 authors...
Radiation exposure such as A-bomb or radiation therapy is considered a major health-risk factor for cardiovascular disease. In order to understand the molecular mechanisms underlying the inflammatory reaction frequently encountered in the vascular system after exposure to ionizing radiation, we carried out a global scale microarray and computational gene expression analyses on human umbilical endothelial cells (HUVECs) exposed to X-ray (2.5 Gy). The gene ontology analysis revealed that the down-...
4 CitationsSource
#1Nobuyuki Hamada (CRIEPI: Central Research Institute of Electric Power Industry)H-Index: 33
#2Yuki Fujimichi (CRIEPI: Central Research Institute of Electric Power Industry)H-Index: 6
Last. Hitoshi Sato (Ibaraki Prefectural University of Health Sciences)H-Index: 9
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In 2011, the International Commission on Radiological Protection issued a statement on tissue reactions (formerly termed non-stochastic or deterministic effects) to recommend lowering the threshold for cataracts and the occupational equivalent dose limit for the crystalline lens of the eye. Furthermore, this statement was the first to list circulatory disease (cardiovascular and cerebrovascular disease) as a health hazard of radiation exposure and to assign its threshold for the heart and brain....
49 CitationsSource
#1Takaharu Nomura (CRIEPI: Central Research Institute of Electric Power Industry)H-Index: 19
#2Kazuo Sakai (CRIEPI: Central Research Institute of Electric Power Industry)H-Index: 10
Last. Junji Magae (CRIEPI: Central Research Institute of Electric Power Industry)H-Index: 29
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While lifespan studies provide basic information for estimating the risk of ionizing radiation, findings on the effect of low-dose/low-dose-rate irradiation on the lifespan of mammals are controversial. Here we evaluate the effect of continuous exposure to low-dose-rate γ radiation on the lifespan of mice with accelerated aging caused by mutation of the klotho gene. While control mice died within 80 days after birth, more than 10% of mice exposed continuously to 0.35 or 0.7 or mGy/h γ radiation ...
21 CitationsSource
#1Yukihiro Furusawa (University of Toyama)H-Index: 20
#2Takashi Iizumi (University of Toyama)H-Index: 3
Last. Takashi Kondo (University of Toyama)H-Index: 52
view all 7 authors...
Abstract Low-intensity ultrasound (US) has been shown to induce death of cancer cells; however, the underlying mechanism remains unclarified. Here, we provide novel evidence that the inhibition of checkpoint kinase 1 (Chk1) by a selective inhibitor or small interfering RNA (siRNA) enhances US-induced apoptosis in Jurkat cells. Jurkat cells showed insignificant lysis immediately after US at any applied intensity, whereas approximately 70% of the cells were γH2AX-positive 30 min after US at 0.4 W/...
1 CitationsSource
#1Takahiro Kataoka (Okayama University)H-Index: 16
#2Junichi Teraoka (Okayama University)H-Index: 4
Last. Kiyonori Yamaoka (Okayama University)H-Index: 28
view all 10 authors...
Control 2000Bq/m3 The online version of the original article can be found at http:// dx.doi.org/10.1007/s10753-011-9364-y. 1 Graduate School of Health Sciences, Okayama University, 5-1 Shikatacho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan 2 Ningyo-toge Environmental Engineering Center, JapanAtomic Energy Agency, 1550 Kagamino-cho, Tomata-gun, Okayama 708-0698, Japan 3 Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical, Sciences, Fukuyama University, 1-Gakuen-cho, Fuku...
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#1Yukihiro Furusawa (University of Toyama)H-Index: 20
#2Zheng Li Wei (University of Toyama)H-Index: 3
Last. Takashi Kondo (University of Toyama)H-Index: 52
view all 9 authors...
Transforming growth factor-β-activated kinase 1 (TAK1) appears to play a role in inhibiting apoptotic death in response to multiple stresses. To assess the role of TAK1 in X-ray induced apoptosis and cell death, we irradiated parental and siRNA-TAK1-knockdown HeLa cells. Changes in gene expression levels with and without TAK1-knockdown were also examined after irradiation to elucidate the molecular mechanisms involved. After X-ray irradiation, cell death estimated by the colony formation assay i...
7 CitationsSource
#1Takahiro Kataoka (Okayama University)H-Index: 16
#2Junichi Teraoka (Okayama University)H-Index: 4
Last. Kiyonori Yamaoka (Okayama University)H-Index: 28
view all 10 authors...
We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema a...
30 CitationsSource