Cathy Burton
St James's University Hospital
Internal medicineLife expectancySurgeryPathologyOncologyChemotherapyFollicular lymphomaMantle cell lymphomaChemotherapy regimenInternational Prognostic IndexDiffuse large B-cell lymphomaLymphomaRituximabRegimenPopulationCancer researchClinical trialMedicineCohortBiology
Publications 32
#1Mary Gleeson (Guy's and St Thomas' NHS Foundation Trust)H-Index: 8
#2Nicholas CounsellH-Index: 22
Last. David C. Linch (UCL: University College London)H-Index: 95
view all 20 authors...
: We compared the International Prognostic Index (IPI), Revised (R)-IPI and age-adjusted (aa)-IPI as prognostic indices for patients with diffuse large B-cell lymphoma (DLBCL) in the UK National Cancer Research Institute (NCRI) R-CHOP 14 versus 21 trial (N = 1080). The R-IPI and aa-IPI showed no marked improvement compared to the IPI for overall and progression-free survival, in terms of model fit or discrimination. Similar results were observed in exploratory analyses incorporating the Grupo Es...
#1Hendrik F P Runge (University of Cambridge)H-Index: 1
#2Stuart E. Lacy (Ebor: University of York)H-Index: 6
Last. Daniel J. Hodson (University of Cambridge)H-Index: 16
view all 11 authors...
HR was funded by a studentship from the Medical Research Council. DH was supported by a Clinician Scientist Fellowship from the Medical Research Council (MR/M008584/1). The Hodson laboratory receives core funding from Wellcome and MRC to the Wellcome-MRC Cambridge Stem Cell Institute and core funding from the CRUK Cambridge Cancer Centre. HMRN is supported by BCUK 15037 and CRUK 18362.
#1Kim Linton (MAHSC: Manchester Academic Health Science Centre)H-Index: 19
#2Joanna M Oladipo (University of Manchester)
Last. John Radford (MAHSC: Manchester Academic Health Science Centre)H-Index: 81
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#1Andrew Davies (University of Southampton)H-Index: 84
#2Josh Caddy (University of Southampton)H-Index: 5
Last. Peter Johnson (University of Southampton)H-Index: 90
view all 17 authors...
1 CitationsSource
#1Pietro R Di Ciaccio (UNSW: University of New South Wales)H-Index: 1
#2Mark N. Polizzotto (UNSW: University of New South Wales)H-Index: 24
Last. Nada Hamad (UNSW: University of New South Wales)H-Index: 9
view all 29 authors...
#1Christopher McNamara (UCLH: University College Hospital)H-Index: 12
#2Silvia MontotoH-Index: 54
Last. Pam McKay (Beatson West of Scotland Cancer Centre)H-Index: 6
view all 11 authors...
1 CitationsSource
#1Stuart E. Lacy (Ebor: University of York)H-Index: 6
#2Sharon BarransH-Index: 15
Last. Daniel J. Hodson (University of Cambridge)H-Index: 16
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Based on the profile of genetic alterations occurring in tumor samples from selected diffuse-large-B-cell-lymphoma (DLBCL) patients, two recent whole exome sequencing studies proposed partially overlapping classification systems. Using clustering techniques applied to targeted sequencing data derived from a large unselected population-based patient cohort with full clinical follow-up (n=928), we investigated whether molecular subtypes can be robustly identified using methods potentially applicab...
32 CitationsSource
#2Cathy Burton (St James's University Hospital)H-Index: 8
Last. Robin PrestwichH-Index: 28
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Abstract Histiocytic sarcoma (HS) is an exceedingly rare and aggressive neoplasm of lymphoid and haematopoietic tissues and expresses histological and phenotypical characteristics of mature histiocytes. There have only been a few cases of documented HS in the head and neck region. Whilst patients with HS often have nodal or disseminated disease, patients can present with localised disease. There are currently no established treatment guidelines, and reported cases of localised disease have been ...
#1Chun Gong (Wellcome Trust)H-Index: 1
#1Chun Gong (Wellcome Trust)H-Index: 1
Last. Daniel J. Hodson (Wellcome Trust)H-Index: 16
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DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma but the functional basis for this is unknown. Here, we show that loss-of-function DDX3X mutations are also commonly found in MYC-translocated diffuse large B cell lymphoma and reveal functional co-operation between mutant DDX3X and MYC. DDX3X promotes translation of mRNAs encoding components of the core translational machinery, thereby driving global prote...
2 CitationsSource
#1Maxine Lamb (Ebor: University of York)H-Index: 5
#2Eve Roman (Ebor: University of York)H-Index: 76
Last. Alexandra Smith (Ebor: University of York)H-Index: 26
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Background Hodgkin lymphoma is usually detected in primary care with early signs and symptoms, and is highly treatable with standardised chemotherapy. However, late presentation is associated with poorer outcomes. Aim To investigate the relationship between markers of advanced disease, emergency admission, and survival following a diagnosis of classical Hodgkin lymphoma (CHL). Design & setting The study was set within a sociodemographically representative UK population-based patient cohort of ~4...
1 CitationsSource