Ruth McNerney
University of Cape Town
Drug resistanceInternal medicineSurgeryGenomeSingle-nucleotide polymorphismVirologyIntensive care medicineImmunologyWhole genome sequencingSputumMycobacterium tuberculosisRifampicinDiseaseMycobacterium tuberculosis complexTuberculosisGeneticsComputational biologyMedicineBiologyMicrobiology
154Publications
47H-index
5,636Citations
Publications 147
Newest
#1João Perdigão (University of Lisbon)H-Index: 20
#2Carla Silva (University of Lisbon)H-Index: 6
Last. Isabel Portugal (University of Lisbon)H-Index: 20
view all 16 authors...
The Beijing genotype comprises a highly disseminated strain type that is frequently associated with multidrug resistant (MDR) tuberculosis (TB) and increased transmissibility but, countries such as...
2 CitationsSource
#1Matthew Ezewudo (Critical Path Institute)H-Index: 7
#2Amanda Borens (Critical Path Institute)H-Index: 3
Last. James E. Posey (CDC: Centers for Disease Control and Prevention)H-Index: 24
view all 29 authors...
Source
#1Wouter Deelder (Lond: University of London)H-Index: 2
#2Sofia Christakoudi (Imperial College London)H-Index: 11
Last. Taane G. Clark (Lond: University of London)H-Index: 2
view all 8 authors...
Background: Tuberculosis disease, caused by Mycobacterium tuberculosis, is a major public health problem. The emergence of M. tuberculosis strains resistant to existing treatments threatens to derail control efforts. Resistance is mainly conferred by mutations in genes coding for drug-targets or -converting enzymes, but our knowledge of these mutations is incomplete. Whole genome sequencing (WGS) is an increasingly common approach to rapidly characterize isolates and identify mutations predictin...
11 CitationsSource
#1Keertan Dheda (South African Medical Research Council)H-Index: 84
#2Tawanda Gumbo (Baylor University Medical Center)H-Index: 51
Last. Clifton E Barry rdH-Index: 1
view all 45 authors...
Summary The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was published in 2017, which comprehensively reviewed and provided recommendations on various aspects of the disease. Several key new developments regarding drug-resistant tuberculosis are outlined in this Commission Update. The WHO guidelines on treating drug-resistant tuberculosis were updated in 2019 with a reclassification of second line anti-tuberculosis drugs. An injection-free MDR tuberculosis treatment regi...
32 CitationsSource
#1João Perdigão (University of Lisbon)H-Index: 20
#2Carla Silva (University of Lisbon)H-Index: 6
Last. Isabel Portugal (University of Lisbon)H-Index: 20
view all 38 authors...
Abstract Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we have assembled and analysed the largest CPLP M. tuberculosis molecular and dr...
13 CitationsSource
#1Keertan Dheda (Lond: University of London)H-Index: 84
#2Laura Lenders (UCT: University of Cape Town)H-Index: 11
Last. Tawanda Gumbo (UCT: University of Cape Town)H-Index: 51
view all 21 authors...
Rationale: There is poor understanding about protective immunity and the pathogenesis of cavitation in patients with tuberculosis.Objectives: To map pathophysiological pathways at anatomically dist...
13 CitationsSource
#1Jody Phelan (Lond: University of London)H-Index: 18
Last. Taane G. Clark (NOVA: Universidade Nova de Lisboa)H-Index: 76
view all 12 authors...
Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work led to the development of the widely used TBProfiler webtool, which predicts resistance to 14 drugs from WGS data. However, for accurate and rapid high throughput of samples in clinical or epidemiological settings, there is a need ...
36 CitationsSource
#1Jody PhelanH-Index: 18
Last. Taane G. ClarkH-Index: 76
view all 12 authors...
Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work led to the development of the widely used TBProfiler webtool, which predicts resistance to 14 drugs from WGS data. However, for accurate and rapid high throughput of samples in clinical or epidemiological settings, there is a need ...
Source
#1João PerdigãoH-Index: 20
#2Carla SilvaH-Index: 6
Last. Isabel PortugalH-Index: 20
view all 38 authors...
#1Matthew Ezewudo (Critical Path Institute)H-Index: 7
#2Amanda Borens (Critical Path Institute)H-Index: 3
Last. James E. Posey (CDC: Centers for Disease Control and Prevention)H-Index: 24
view all 29 authors...
Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is a collaborative, curated knowledgebase, designed to standardize and aggregate global Mycobacterium tuberculosis complex (MTBC) variant data from whole genome sequencing (WGS) with phenotypic drug susceptibility testing (DST) and clinical data. We developed a unified analysis variant pipeline (UVP) ( https://github.com/CPTR-ReSeqTB/UVP ) to identify variants and assign lineage from MTBC sequence data. Str...
31 CitationsSource