Alexander T. Cohen
Guy's and St Thomas' NHS Foundation Trust
CancerInternal medicineSurgeryRandomized controlled trialIntensive care medicinePulmonary embolismWarfarinLow molecular weight heparinRivaroxabanDeep veinVenous thrombosisEdoxabanBetrixabanApixabanThrombosisPopulationVenous thromboembolismStrokeClinical trialMedicine
316Publications
59H-index
24.1kCitations
Publications 166
Newest
#1Alexander T. Cohen ('KCL': King's College London)H-Index: 41
#1Alexander T. Cohen ('KCL': King's College London)H-Index: 59
Last. Ingrid M. Bistervels (UvA: University of Amsterdam)H-Index: 6
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1 CitationsSource
#1Alexander T. Cohen (Guy's and St Thomas' NHS Foundation Trust)H-Index: 59
#2Allison KeshishianH-Index: 10
Last. Xuemei Luo (Pfizer)H-Index: 22
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Objective: This pooled claims database study evaluated the risk of recurrent Venous Thromboembolism (VTE) and major bleeding (MB) among patients with VTE and active cancer prescribed apixaban, low-molecular weight heparin (LMWH), or warfarin stratified by high-risk subgroups.Methods: Patients diagnosed with VTE in the setting of active cancer who initiated apixaban, LMWH, or warfarin were identified using four US commercial claims databases from 01SEP2014 to the end of the study period (MarketSc...
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#1Alexander T. CohenH-Index: 59
#2Sharon Pan (Pfizer)H-Index: 10
Last. Theodore C. Lee (Pfizer)H-Index: 11
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INTRODUCTION As a result of limited clinical data, guidelines do not recommend the use of non-vitamin K antagonist oral anticoagulants in patients who weigh > 120 kg or have a body mass index (BMI) > 40 kg/m2. METHODS This post hoc analysis of the AMPLIFY trial evaluated the efficacy (venous thromboembolism [VTE]/VTE-related death), safety (major and composite of major and clinically relevant non-major [CRNM] bleeding), and exposure of apixaban compared with enoxaparin followed by warfarin for t...
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#1Michela Giustozzi (University of Perugia)H-Index: 12
#2Luca Valerio (University of Mainz)H-Index: 12
Last. Stefano Barco (University of Mainz)H-Index: 21
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Abstract Introduction Sex and the presence of specific provoking risk factors, along with age, influence the presentation and prognosis of venous thromboembolism (VTE). We investigated the presentation, course and quality of life in women and men with acute VTE classified according to their VTE provoking factors. Methods PREFER in VTE is an international, non-interventional registry of patients with a first episode of acute symptomatic VTE. Baseline provoking factors were classified as follows: ...
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#1Alexander T. Cohen (Guy's and St Thomas' NHS Foundation Trust)
#1Alexander T. Cohen (Guy's and St Thomas' NHS Foundation Trust)H-Index: 59
Last. Xuemei Luo (Pfizer)H-Index: 22
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Background This study primarily evaluates the risk of recurrent venous thromboembolism (VTE) and major bleeding (MB) among patients with VTE and active cancer prescribed apixaban, low-molecular-weight heparin (LMWH), or warfarin, with claims data. Methods Four U.S. commercial insurance claims databases were used to identify patients with VTE and active cancer who initiated apixaban, LMWH, or warfarin within 30 days following the first VTE event. Stabilized inverse-probability treatment weighting...
2 CitationsSource
#1Mauricio Concha (Memorial Hospital of South Bend)H-Index: 4
#2Alexander T. Cohen (Guy's and St Thomas' NHS Foundation Trust)H-Index: 59
Last. Alexander T. Cohen (Guy's and St Thomas' NHS Foundation Trust)
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Intracerebral bleeds related to anticoagulant use have a poor prognosis and substantial risk of disability and death. Recent publications evaluating replacement or reversal therapies for anticoagulants lack consistency in controlling for key factors that significantly influence outcomes. In an effort to guide future research by providing a framework to improve consistency and reduce the potential for confounding in this dynamic and highly time-dependent brain insult, we provide here a brief over...
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#1Anne Céline Martin (University of Paris)H-Index: 1
#2W. Thomas (Cambridge University Hospitals NHS Foundation Trust)H-Index: 1
Last. Alexander T. CohenH-Index: 59
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Background Direct oral anticoagulants (DOACs) are prescribed for atrial fibrillation (AF) and venous thromboembolism (VTE) and both occur more frequently in obese patients. Outcomes from DOAC trials included few individuals ≥ 120 kg leading to uncertainty whether high body weight (BW) reduces DOAC concentrations. Objectives This article investigates the relationship between factor Xa (FXa) inhibitor concentrations, BW, and renal function, and compares them in high BW patients with unselected pop...
4 CitationsSource
#1Nils PickerH-Index: 2
#2Agnes Y.Y. Lee (UBC: University of British Columbia)H-Index: 55
Last. Thomas WilkeH-Index: 18
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Introduction Clinical guidelines recommend anticoagulation therapy for the treatment of cancer-associated venous thromboembolism (VTE), but little is known about preferences. Therefore, the objective of this discrete choice experiment (DCE) was to elucidate patient preferences regarding anticoagulation convenience attributes. Methods Adult patients with cancer-associated VTE who switched to direct oral anticoagulants were included in a single-arm study (COSIMO). Patients were asked to decide bet...
1 CitationsSource
#1Alexander T. Cohen (Guy's and St Thomas' NHS Foundation Trust)H-Index: 59
#1Alexander T. Cohen (Guy's and St Thomas' NHS Foundation Trust)
Last. Xuemei Luo (Pfizer)H-Index: 22
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This study integrated 5 United States healthcare claims databases to evaluate the risk of recurrent venous thromboembolism (VTE) and major bleeding (MB) among VTE patients who initiated apixaban vs. warfarin, stratified by obesity. Obese and morbidly obese patients were identified based on diagnosis codes. Stabilized inverse probability treatment weighting (IPTW) was conducted to balance observed patient characteristics between treatment cohorts. An interaction analysis was conducted to evaluate...
1 CitationsSource