C. Stucchi
Quality assurancePhysicsInternal medicineRadiologyUrologyOncologyIonLinear particle acceleratorFecal incontinenceTotal body irradiationProstate cancerPopulationNuclear medicineVolumetric modulated arc therapyIn patientComputer scienceCancer researchRadiation therapyMedicinePulmonary function testingBiology
38Publications
10H-index
284Citations
Publications 38
Newest
#1Rihan El BezawyH-Index: 3
#2Martina Tripari (University of Liverpool)H-Index: 1
Last. Nadia ZaffaroniH-Index: 66
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Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is the most commonly mutated gene in prostate cancer (PCa). Recent evidence reports a role of SPOP in DNA damage response (DDR), indicating a possible impact of SPOP deregulation on PCa radiosensitivity. This study aimed to define the role of SPOP deregulation (by gene mutation or knockdown) as a radiosensitizing factor in PCa preclinical models. To express WT or mutant (Y87N, K129E and F133V) SPOP, DU145 and PC-3 cells were tra...
1 CitationsSource
#1F. BonfantiniH-Index: 6
#2Tommaso GiandiniH-Index: 4
Last. Emanuele PignoliH-Index: 19
view all 9 authors...
PURPOSE: To apply Failure Mode and Effects Analysis (FMEA) to optimize linac quality control (QC) protocol in order to ensure patient safety and treatment quality, taking maximum advantage of the available resources. MATERIAL AND METHODS: Each parameter tested by the QC was considered as a potential failure mode (FM). For each FM, likelihood of occurrence (O), severity of effect (S), and lack of detectability (D) were evaluated and corresponding Risk Priority Number (RPN) was calculated from the...
1 CitationsSource
#1Barbara DilettoH-Index: 7
#2E. PecoriH-Index: 2
Last. Lorenza GandolaH-Index: 1
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Background Radiotherapy is one of the main treatment options for non-metastatic prostate cancer (PCa). Although treatment technical optimization has greatly improved local tumor control, a considerable fraction of patients still experience relapse due to the development of resistance. Radioresistance is a complex and still poorly understood phenomenon involving the deregulation of a variety of signaling pathways as a consequence of several genetic and epigenetic abnormalities. In this context, c...
28 CitationsSource
#1Mauro CarraraH-Index: 16
#2Eleonora MassariH-Index: 2
Last. Riccardo Valdagni (University of Milan)H-Index: 51
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Purpose This study was designed to apply artificial neural network (ANN) classification methods for the prediction of late fecal incontinence (LFI) after high-dose prostate cancer radiation therapy and to develop a ready-to-use graphical tool. Materials and Methods In this study, 598 men recruited in 2 national multicenter trials were analyzed. Information was recorded on comorbidity, previous abdominal surgery, use of drugs, and dose distribution. Fecal incontinence was prospectively evaluated ...
4 CitationsSource
#1A. D’Alessio (University of Milan)
#2E. D’Ippolito (University of Milan)H-Index: 3
Last. Emanuele PignoliH-Index: 19
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Purpose CT imaging in radiotherapy represents the standard for treatment planning. The calculation of dose distribution requires appropriate energy-dependent calibration curves to convert Hounsfield Units (HU) into electronic densities relative to water (rEDs). To obtain optimal image quality and reduce dose, it could be useful to modulate X-ray tube potential based on patient size, but in radiotherapy treatment planning this practice requires the use of several calibration curves. A novel algor...
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#2Tiziana RancatiH-Index: 27
Last. Riccardo Valdagni (University of Milan)H-Index: 51
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Purpose To develop a modelling procedure for late rectal bleeding (LRB) that goes beyond maximum likelihood model fitting of data. Thus, to create a metamodel for grade 2–3 (G23) and grade 3 (G3) LRB starting from literature evidence and validate it on a large population. Methods Metamodelling allows to highlight specific features of the model itself. Characteristics that predictive models for LRB have in common are: the global harmony of radiobiological parameters (volume effect parameter, n, s...
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#1Alessandro Cicchetti (UNIPV: University of Pavia)H-Index: 7
#2Barbara AvuzziH-Index: 11
Last. Riccardo Valdagni (University of Milan)H-Index: 51
view all 13 authors...
Purpose This study aimed to validate a previously published predictive model for late fecal incontinence (FI) in a contemporary population of prostate cancer patients treated with radical radiation therapy. Methods and Materials The validation included patients treated with intensity-modulated radiation therapy (IMRT) (2010-2014). Prescribed dose range was 65-80 Gy, including conventional and moderate hypo-fractionated treatments. Rectal toxicity was scored using LENT/SOMA, a minimum 2-year foll...
7 CitationsSource
#2Tiziana RancatiH-Index: 27
Last. R. ValdagniH-Index: 4
view all 16 authors...
Source
61Background: Predictive models for late rectal bleeding (LRB) after radiotherapy (RT) for prostate cancer were established by several studies, with good performance on development population (POP). Nonetheless, they were found to be unsatisfactory in their generalization to independent validation cohorts. Aim of the study is to build a metamodel for grade 2-3 (G23) and grade 3 (G3) LRB (LENT/SOMA) starting from literature evidence and to validate it on a new POP. Methods: The metamodel was cons...
1 CitationsSource