James B. Brewer
University of California, San Diego
Internal medicinePathologyMagnetic resonance imagingOncologyPsychologyNeuroscienceCognitionAlzheimer's Disease Neuroimaging InitiativeDiseaseDementiaTemporal lobeAtrophyCognitive declineAlzheimer's diseaseApolipoprotein ENeuroimagingMedicineBiomarker (medicine)BiologyAmyloid
167Publications
50H-index
8,892Citations
Publications 159
Newest
#1Julia Neitzel (LMU: Ludwig Maximilian University of Munich)H-Index: 11
#2Nicolai Franzmeier (LMU: Ludwig Maximilian University of Munich)H-Index: 18
Last. William J. JagustH-Index: 140
view all 0 authors...
Klotho-VS heterozygosity (KL-VShet) is associated with reduced risk of Alzheimer’s disease (AD). However, whether KL-VShet is associated with lower levels of pathologic tau, i.e., the key AD pathology driving neurodegeneration and cognitive decline, is unknown. Here, we assessed the interaction between KL-VShet and levels of beta-amyloid, a key driver of tau pathology, on the levels of PET-assessed neurofibrillary tau in 551 controls and patients across the AD continuum. KL-VShet showed lower cr...
Source
#1Sarah J. Banks (UCSD: University of California, San Diego)H-Index: 21
#2Murray J. Andrews (UCSD: University of California, San Diego)H-Index: 2
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
view all 0 authors...
Abstract null null To determine if sex differences in verbal memory in AD are related to differences in extent or distribution of pathological tau, we studied 275 participants who were amyloid PET positive and carried clinical classifications of normal cognition, mild cognitive impairment (MCI) or dementia, and had tau (AV1451) PET. We compared tau distribution between men and women, and as a function of genetic risk. In MCI we further explored the relationship between quantity and distribution ...
Source
#1Derek A. Kellar (Wake Forest University)H-Index: 2
#2Samuel N. Lockhart (Wake Forest University)H-Index: 21
Last. Suzanne Craft (Wake Forest University)H-Index: 92
view all 7 authors...
Intranasally administered insulin has shown promise in both rodent and human studies in Alzheimer’s disease; however, both effects and mechanisms require elucidation. We assessed the effects of intranasally administered insulin on white matter health and its association with cognition and cerebral spinal fluid biomarker profiles in adults with mild cognitive impairment or Alzheimer’s disease in secondary analyses from a prior phase 2 clinical trial (NCT01767909). A randomized (1:1) double-blind ...
1 CitationsSource
#1Barbara E. Spencer (UCSD: University of California, San Diego)H-Index: 2
#2Leonardino A. Digma (UCSD: University of California, San Diego)H-Index: 2
view all 5 authors...
Introduction Elevated β-amyloid is used to enroll individuals into preclinical Alzheimer's disease trials, but the screening process is inefficient and expensive. Novel enrichment methods are needed to improve efficiency of enrollment. Methods Alzheimer's disease incidence rates and a polygenic hazard score were used to create a gene- and age-defined ADAge. An ADAge cutpoint was chosen to optimally predict β-amyloid positivity among clinically normal Alzheimer's Disease Neuroimaging Initiative p...
Source
#1Murray J. Andrews (UCSD: University of California, San Diego)H-Index: 2
#2Ryan Ross (UCSD: University of California, San Diego)
view all 7 authors...
Author(s): Andrews, Murray; Ross, Ryan; Malhotra, Atul; Ancoli-Israel, Sonia; Brewer, James B; Banks, Sarah J; Alzheimer’s Disease Neuroimaging Initiative | Abstract: BackgroundThe increasing prevalence of Alzheimer's disease (AD) and lack of effective medications has led to a need to identify modifiable risk factors as targets for interventions.ObjectiveIn this cross-sectional study, we sought to determine whether worse sleep quality is associated with increased pathological tau, and whether th...
Source
#1Brian W. Kunkle (UM: University of Miami)H-Index: 20
#2Michael A. Schmidt (UM: University of Miami)H-Index: 12
Last. Walter A. Kukull (UW: University of Washington)H-Index: 100
view all 78 authors...
Importance Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in non-Hispanic White individuals. In the largest association analyses of Alzheimer disease in African American individuals, ABCA7, TREM2, and an intergenic locus at 5q35 were previously implicated. Objective To ...
10 CitationsSource
#1Shusuke TodenH-Index: 26
#2Jiali ZhuangH-Index: 8
Last. Arkaitz IbarraH-Index: 2
view all 11 authors...
The lack of accessible noninvasive tools to examine the molecular alterations occurring in the brain limits our understanding of the causes and progression of Alzheimer's disease (AD), as well as the identification of effective therapeutic strategies. Here, we conducted a comprehensive profiling of circulating, cell-free messenger RNA (cf-mRNA) in plasma of 126 patients with AD and 116 healthy controls of similar age. We identified 2591 dysregulated genes in the cf-mRNA of patients with AD, whic...
1 CitationsSource
#1Barbara E. Spencer (UCSD: University of California, San Diego)H-Index: 2
#2Leonardino A. Digma (UCSD: University of California, San Diego)H-Index: 2
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
view all 4 authors...
Source
#1Sarah J. Banks (UCSD: University of California, San Diego)H-Index: 21
#2Murray J. Andrews (UCSD: University of California, San Diego)H-Index: 2
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
view all 6 authors...
Source
#1Denis S. Smirnov (UCSD: University of California, San Diego)H-Index: 4
#2Katherine J. Bangen (UCSD: University of California, San Diego)H-Index: 29
Last. David P. Salmon (UCSD: University of California, San Diego)H-Index: 114
view all 5 authors...
1 CitationsSource