Rajiv R. Mohan
University of Missouri
Genetic enhancementOphthalmologyGene deliveryPathologyMolecular biologyStromal cellChemistryIn vivoMyofibroblastCorneaDecorinWound healingFibrosisPhotorefractive keratectomyCorneal fibrosisCorneal HazeToxicityCancer researchMedicineBiologyCell biology
Publications 214
#1Nishant Sinha (MU: University of Missouri)H-Index: 10
#2Alexandria Hofmann (MU: University of Missouri)H-Index: 1
Last. Shyam S. Chaurasia (MU: University of Missouri)H-Index: 40
view all 0 authors...
#1Allison A Fuchs (MU: University of Missouri)H-Index: 1
#2Elizabeth A. Giuliano (MU: University of Missouri)H-Index: 21
Last. Rajiv R. Mohan (MU: University of Missouri)H-Index: 43
view all 4 authors...
Abstract Sulfur mustard (SM) is a chemical warfare agent that has been used throughout recent history and remains a threat today. Exposed soldiers and civilians experience a variety of symptoms primarily in the respiratory system, skin, and eyes. The ocular tissues are highly sensitive to damage by SM and undergo unique manifestations of acute, chronic, and delayed complications that can persist for months and years after exposure. The mechanisms of this unique mustard gas keratopathy are still ...
#1Praveen Balne (MU: University of Missouri)H-Index: 1
#2Suneel Gupta (MU: University of Missouri)H-Index: 12
Last. Renato V. Iozzo (Thomas Jefferson University)H-Index: 126
view all 10 authors...
Abstract Our earlier decorin (Dcn) gene overexpression studies found that the targeted Dcn gene transfer into the cornea inhibited corneal angiogenesis in vivo using a rabbit model. In this study, we tested the hypothesis that anti-angiogenic effects of decorin in the cornea are mediated by alterations in a normal physiologic balance of pro- and anti-angiogenic factors using decorin deficient (Dcn −/−) and wild type (Dcn +/+) mice. Corneal neovascularization (CNV) in Dcn −/− and Dcn +/+ mice was...
#1Archana Padmanabhan Nair (Manipal University)H-Index: 3
#2Sharon D'SouzaH-Index: 9
Last. Swaminathan SethuH-Index: 19
view all 14 authors...
Abstract Purpose Aberrant inflammation and immune dysregulation are known pathogenic contributors in dry eye disease (DED). Aim of the study was to determine the proportions of immune cell subsets on the ocular surface (OS) of DED patients. Methods 15 healthy controls (22 eyes) and 48 DED subjects (36 eyes with evaporative DED – EDED; 60 eyes with aqueous deficient DED – ADED) were included in the study. Tear break up time (TBUT), Schirmer's test 1 (ST1), corneal staining (CS) and ocular surface...
#1Suneel Gupta (MU: University of Missouri)H-Index: 12
#2Sabeeh Kamil (MU: University of Missouri)H-Index: 2
Last. Rajiv R. Mohan (MU: University of Missouri)H-Index: 43
view all 6 authors...
Toxic and volatile chemicals are widely used in household products and previously used as warfare agents, causing a public health threat worldwide. This study aimed to evaluate the extent of injury and mechanisms of acrolein toxicity in the cornea. Primary human corneal stromal fibroblasts cultures (hCSFs) from human donor cornea were cultured and exposed to acrolein toxicity with -/+ N-acetylcysteine (NAC) to study the mode of action in the presence of Buthionine sulphoximine (BSO). PrestoBlue ...
#1Rohit ShettyH-Index: 30
#2Nimisha R KumarH-Index: 6
Last. Debashish DasH-Index: 12
view all 11 authors...
Corneal haze post refractive surgery is prevented by mitomycin c (MMC) treatment though it can lead to corneal endothelial damage, persistent epithelial defects and necrosis of cells. Suberanilohydroxamic acid (SAHA) however has been proposed to prevent corneal haze without any adverse effects. For clinical application we have investigated the short and long term outcome of cells exposed to SAHA. Human donor cornea, cultured limbal epithelial cells, corneal rims and lenticules were incubated wit...
#1Sabeeh Kamil (MU: University of Missouri)H-Index: 2
#2Rajiv R. Mohan (MU: University of Missouri)H-Index: 43
Abstract Corneal stromal wound healing is a complex event that occurs to restore the transparency of an injured cornea. It involves immediate apoptosis of keratocytes followed by their activation, proliferation, migration, and trans-differentiation to myofibroblasts. Myofibroblasts contract to close the wound and secrete extracellular matrix and proteinases to remodel it. Released proteinases may degenerate the basement membrane allowing an influx of cytokines from overlying epithelium. Immune c...
3 CitationsSource
#1Rajiv R. Mohan (MU: University of Missouri)H-Index: 43
#2Lynn M. Martin (MU: University of Missouri)H-Index: 17
Last. Nishant Sinha (MU: University of Missouri)H-Index: 10
view all 3 authors...
Abstract Corneal disease remains a leading cause of impaired vision world-wide, and advancements in gene therapy continue to develop with promising success to prevent, treat and cure blindness. Ideally, gene therapy requires a vector and gene delivery method that targets treatment of specific cells or tissues and results in a safe and non-immunogenic response. The cornea is a model tissue for gene therapy due to its ease of clinician access and immune-privileged state. Improvements in the past 5...
2 CitationsSource
#1Suneel Gupta (MU: University of Missouri)H-Index: 12
#1Suneel Gupta (MU: University of Missouri)H-Index: 1
Last. Rajiv R. MohanH-Index: 43
view all 8 authors...
Purpose Inhibitor of differentiation (Id) proteins are helix-loop-helix (HLH) transcriptional repressors that modulate a range of developmental and cellular processes, including cell differentiation and cell cycle mobilization. The inhibitor of differentiation 3 (Id3) gene, a member of the Id gene family, governs the expression and progression of transforming growth factor beta (TGFβ)-mediated cell differentiation. In the face of mechanical, chemical, or surgical corneal insults, corneal keratoc...
#1Patrick M. McNutt (United States Army Medical Research Institute of Chemical Defense)H-Index: 17
#2Rajiv R. Mohan (MU: University of Missouri)H-Index: 43
Cornea, a highly specialized transparent tissue, is the major refractive element of the eye. The cornea is highly susceptible to chemotoxic injury through topical exposure to vapors, microparticles, and aqueous drops, as well as through systemically absorbed chemicals that access the cornea via tear film, aqueous humor, and limbal vasculature. Corneal injury activates a carefully orchestrated series of repair processes capable of resolving minor lesions over time, but it often fails to overcome ...