Igor Grant
University of California, San Diego
PsychiatryInternal medicineDevelopmental psychologyNeuropsychologyViral loadPsychologyCognitionNeurocognitiveImmunologyDepression (differential diagnoses)DiseaseDementiaCerebrospinal fluidMethamphetamineAcquired immunodeficiency syndrome (AIDS)Human immunodeficiency virus (HIV)Clinical psychologyMedicineCohortGerontologyBiology
854Publications
130H-index
48.5kCitations
Publications 852
Newest
#1Taylor Bos (UCSD: University of California, San Diego)H-Index: 4
#2Vanessa L. Malcarne (UCSD: University of California, San Diego)H-Index: 44
Last. Brent T. Mausbach (UCSD: University of California, San Diego)H-Index: 60
view all 4 authors...
The present study evaluated the psychometric properties of scores from the Behavioral Activation for Depression Scale Short Form (BADS-SF) in a sample of older age, spousal, Alzheimer’s caregivers ...
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#1Benjamin Z. Roberts (UCSD: University of California, San Diego)H-Index: 2
#2Arpi Minassian (VA: United States Department of Veterans Affairs)H-Index: 34
Last. Jared W. Young (Veterans Health Administration)H-Index: 50
view all 8 authors...
BACKGROUND HIV-associated Neurocognitive Disorder (HAND) is commonly observed in persons living with HIV (PWH), and is characterized by cognitive deficits implicating disruptions of fronto-striatal neurocircuitry. Such circuitry is also susceptible to alteration by cannabis and other drugs of abuse. PWH use cannabis at much higher rates than the general population, thus prioritizing the characterization of any interactions between HIV and cannabinoids on cognitively relevant systems. Prepulse in...
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#1Benjamin Z. Roberts (UCSD: University of California, San Diego)H-Index: 2
#2Yinong V. He (UCSD: University of California, San Diego)H-Index: 1
Last. Jared W. Young (Veterans Health Administration)H-Index: 50
view all 6 authors...
The HIV transgenic (HIVtg) rat is a commonly used animal model of chronic HIV infection that exhibits a wide range of cognitive deficits. To date, relatively little work has been conducted on these rats' capacity for reversal learning, an assay of executive function and cognitive flexibility used in humans. The present study sought to determine the impact of HIV genotype on probabilistic reversal learning, effortful motivation, and spontaneous locomotion/exploration in rats. Male (n = 8) and fem...
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#1C. Wei-Ming Watson (UC: University of California)
#1Caitlin Wei-Ming Watson (UCSD: University of California, San Diego)H-Index: 4
Last. Robert K. Heaton (UCSD: University of California, San Diego)H-Index: 119
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OBJECTIVE Recent cannabis exposure has been associated with lower rates of neurocognitive impairment in people with HIV (PWH). Cannabis's anti-inflammatory properties may underlie this relationship by reducing chronic neuroinflammation in PWH. This study examined relations between cannabis use and inflammatory biomarkers in cerebrospinal fluid (CSF) and plasma, and cognitive correlates of these biomarkers within a community-based sample of PWH. METHODS 263 individuals were categorized into four ...
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#1T. Jordan WalterH-Index: 1
Last. Igor GrantH-Index: 130
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Methamphetamine (METH) use disorder is highly prevalent among people with HIV (PWH) and is a significant public health problem. HIV and METH use are each associated with immune system dysfunction; however, the combined effects on the immune system are poorly understood. This cross-sectional project measured soluble immune biomarkers in plasma and cerebrospinal fluid (CSF) collected from a control group, people with a history of a METH use disorder (METH+), PWH with no history of METH use disorde...
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#1Jacqueline A. Hubbard (UCSD: University of California, San Diego)H-Index: 9
#2Melissa A Hoffman (UCSD: University of California, San Diego)H-Index: 6
Last. Marilyn A. Huestis (Thomas Jefferson University)H-Index: 95
view all 14 authors...
Proving driving under the influence of cannabis (DUIC) is difficult. Establishing a biomarker of recent use to supplement behavioral observations may be a useful alternative strategy. We determined whether cannabinoid concentrations in blood, oral fluid (OF), or breath could identify use within 3h, likely the period of greatest impairment. In a randomized trial, 191 frequent (≥4/week) and occasional (<4/week) cannabis users smoked one cannabis (placebo [0.02%], 5.9% or 13.4% THC) cigarette ad li...
1 CitationsSource
#1Melissa A Hoffman (UCSD: University of California, San Diego)H-Index: 6
#2Jacqueline A. Hubbard (UCSD: University of California, San Diego)H-Index: 9
Last. Marilyn A. Huestis (Thomas Jefferson University)H-Index: 95
view all 14 authors...
Increased prevalence of cannabis consumption and impaired driving are a growing public safety concern. Some states adopted per se driving laws, making it illegal to drive with more than a specified ∆9-tetrahydrocannabinol (THC) blood concentration of THC in a biological fluid (typically blood). Blood THC concentrations decrease significantly (~90%) with delays in specimen collection, suggesting use of alternative matrices, such as oral fluid (OF). We characterized 10 cannabinoids' concentrations...
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#1Carlos Vara-García (URJC: King Juan Carlos University)H-Index: 5
#2Brent T. Mausbach (UCSD: University of California, San Diego)H-Index: 60
Last. Igor Grant (UCSD: University of California, San Diego)H-Index: 130
view all 6 authors...
Abstract null null Objective null Caring for a relative with dementia is considered a chronically stressful role associated with negative consequences for psychological health such as higher levels of depression. However, the subjective experience of depressive symptomatology is complex as it relates to two unique domains: positive affect (PA) and negative affect (NA). The objective of this study was to analyze, through a longitudinal design, the associations of caregivers’ cognitive (avoidance ...
1 CitationsSource
#1Albert M Anderson (RTP: Research Triangle Park)
#2Bin TangH-Index: 6
Last. Scott LetendreH-Index: 65
view all 11 authors...
Background Cognitive complications persist in persons with HIV (PWH) during suppressive antiretroviral therapy (ART). Low levels of HIV during ART could contribute to these complications. In this study, we measured cerebrospinal fluid (CSF) HIV using a single copy assay (SCA) to investigate a possible relationship between low level HIV and cognition.Design/Methods: SCA data were analyzed from three consecutive paired CSF-plasma specimens collected over a mean of 456 days from 96 participants on ...
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#1Sanjay Mehta (UCSD: University of California, San Diego)H-Index: 44
#2Jennifer E. Iudicello (UCSD: University of California, San Diego)H-Index: 23
Last. Scott Letendre (UCSD: University of California, San Diego)H-Index: 65
view all 12 authors...
Abstract Background HIV infection and methamphetamine dependence (METH) are each associated with inflammation and premature aging, but their impact on biological aging is difficult to measure. Here we examined the impact of HIV and METH on leukocyte telomere lengths (LTL), and the correlations between LTL and other aging biomarkers. Methods The study was a cross-sectional analysis of 161 individuals categorized by HIV and methamphetamine (METH) dependence status into four groups: HIV-METH- (n = ...
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