Fei-bin Zhu
Nanchang University
EndocrinologyCellAndrologyIn vitroSensory nerveSubstance PNerve fiberStreptozotocinWound healingTrypsinType I collagenStem cellTransplantationProliferating cell nuclear antigenDiabetes mellitusClone (cell biology)MedicineKeratinBiologyEpidermis (botany)
Publications 4
#1Fei-bin Zhu (NCU: Nanchang University)H-Index: 1
#2Xiang-jing FangH-Index: 1
Last. De-ming Liu (NCU: Nanchang University)H-Index: 4
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Exogenous substance P accelerates wound healing in diabetes, but the mechanism remains poorly understood. Here, we established a rat model by intraperitoneally injecting streptozotocin. Four wounds (1.8 cm diameter) were drilled using a self-made punch onto the back, bilateral to the vertebral column, and then treated using amniotic membrane with epidermal stem cells and/or substance P around and in the middle of the wounds. With the combined treatment the wound-healing rate was 100% at 14 days....
5 CitationsSource
#1Fei-bin Zhu (NCU: Nanchang University)H-Index: 1
#2Dewu LiuH-Index: 3
Last. Yong-tie LiH-Index: 2
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OBJECTIVE: To observe the effect of sensory neuropeptide substance P combined with epidermal stem cells (ESC) on wound healing and nerve regeneration in diabetic rats. METHODS: ESC that had been isolated from SD rats were identified and cultured in vitro, and they were inoculated onto nourishing layer of amniotic membrane to construct amniotic membrane-ESC. Four full-thickness skin wounds were produced on the back of each of 48 diabetic rats. The resulted 192 wounds were randomly divided into ES...
1 Citations
#1Fei-bin Zhu (NCU: Nanchang University)H-Index: 1
#2Dewu Liu (NCU: Nanchang University)H-Index: 6
Last. Pu Ning (NCU: Nanchang University)H-Index: 3
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Epidermal stem cells (ESCs) play a critical roles in wound healing. But the biological characteristics of ESCs derived from diabetes mellitus are not fully understood. In this chapter, we compared the biological characteristics between diabetes and normal skin derived ESCs in vitro. The diabetes mellitus (DM) rat models were made by intraperitoneal injected streptozotocin. ESCs were extracted from the dorsal skin samples of rats by trypsin digesting method and further purified by collagen adheri...
#1Qingling Zhong (NCU: Nanchang University)H-Index: 4
#2Fanrong Liu (NCU: Nanchang University)H-Index: 6
Last. Fei-bin Zhu (NCU: Nanchang University)H-Index: 1
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β-catenin plays an important role in the tissue repair. But its expression and meanings in the diabetic cutaneous wound remains to be determined. In this study, we investigated the expression of β-catenin and PCNA in epidermal stem cells(ESCs) of diabetic rat skin. The diabetes mellitus (DM) rats were induced by a single i.p. injection of streptozotocin. ESCs were extracted from the dorsal skin samples of rats by trypsin digesting method and further purified by collagen adhering method...