Matteo Morotti
Churchill Hospital
Internal medicineRadiologyObstetricsSurgeryOncologyStage (cooking)ChemotherapyDiseasePregnancyGlutamineEndometriosisLaparoscopyPelvic painOvarian cancerDebulkingStage IIICGynecologyCancer researchBreast cancerMedicineBiologyCancer cellPharmacology
Publications 74
#1Ciro Pinelli (University of Insubria)H-Index: 12
#2Matteo Morotti (Churchill Hospital)H-Index: 19
Last. Hooman Soleymani Majd (Churchill Hospital)H-Index: 10
view all 8 authors...
Background: Elderly ovarian cancer (OC) patients are more likely to be managed suboptimally, with worse clinical outcomes as a result. Strategies to decrease morbidity are lacking.Methodology: Consecutive patients with advanced stage OC (IIIC-IV) who were managed in our center between January 2016 and July 2018 were retrospectively analyzed. All patients underwent neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) according to our institution protocol. We divided patients into ...
3 CitationsSource
#1Matteo MorottiH-Index: 19
#2Gaetano ValentiH-Index: 1
Last. Tingyan ShiH-Index: 2
view all 4 authors...
#1Ciro Pinelli (University of Insubria)H-Index: 12
#2Matteo Morotti (Churchill Hospital)H-Index: 19
Last. Hooman Soleymani Majd (Churchill Hospital)H-Index: 10
view all 7 authors...
AbstractBackground: Several studies have demonstrated the feasibility and role of bulky cardiophrenic lymph nodes (CPLNs) resection during primary debulking surgery (PDS) for stage IV ovarian cance...
4 CitationsSource
#1Susan Addley (University of Oxford)H-Index: 1
#2Matteo Morotti (University of Oxford)H-Index: 19
Last. Hooman Soleymani Majd (University of Oxford)H-Index: 10
view all 4 authors...
Abstract null null Surgery in advanced ovarian malignancy is indicated when complete debulking can be achieved. In patients with disease above the diaphragm, achieving R0 can present a surgical challenge and bring into question the feasibility of surgery.
#1Mara ArtibaniH-Index: 7
#2Kenta Masuda (University of Oxford)H-Index: 22
Last. Ahmed Ashour AhmedH-Index: 28
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Similar to tumor initiating cells (TICs), minimal residual disease (MRD) is capable of re-initiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy. We reveal that while MRD cells share important molecular signatures with TICs, they are also characterized ...
#1Matteo Morotti (University of Oxford)H-Index: 19
#1Ahmed Ashour AhmedH-Index: 28
Last. D C Wedge
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Cancer is a leading cause of death worldwide and, despite new targeted therapies and immunotherapies, many patients with advanced-stage- or high-risk cancers still die, owing to metastatic disease. Adoptive T-cell therapy, involving the autologous or allogeneic transplant of tumour-infiltrating lymphocytes or genetically modified T cells expressing novel T-cell receptors or chimeric antigen receptors, has shown promise in the treatment of cancer patients, leading to durable responses and, in som...
4 CitationsSource
#1Laura Santana Gonzalez (University of Oxford)H-Index: 3
#2Ioanna A. Rota (University of Oxford)H-Index: 3
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 10 authors...
The conduits of life; the animal oviducts and human fallopian tubes are of paramount importance for reproduction in amniotes. They connect the ovary with the uterus and are essential for fertility as they provide the appropriate environment for gamete maintenance, fertilisation and preimplantation embryonic development. However, some of the most serious pathologies, such as ectopic pregnancy, malignancy and severe infections, occur in the oviducts. They can have drastic effects on fertility, and...
1 CitationsSource
#1Matteo Morotti (University of Oxford)H-Index: 19
#2Hooman Soleymani Majd (University of Oxford)H-Index: 10
Last. Stephen Damato (University of Oxford)H-Index: 3
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High-grade endometrial cancers (ECs) are an aggressive subset of ECs accounting for 70-80% of EC-related deaths. Currently, staging surgery, together with chemotherapy or radiotherapy, is the primary treatment strategy for these cancers. The widespread use of next-generation sequencing has led to a refined understanding of EC's genomics with important information for diagnosis and therapy for individual patients (precision medicine). However, advances in the genomics assessment of high-grade tum...
1 CitationsSource
#2Matteo MorottiH-Index: 19
Last. Adrian L. Harris (University of Oxford)H-Index: 191
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Background Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be dependent on Gln to produce the energy required for survival and proliferation. Despite intense research on the role of the intracellular Gln pathway, few reports have focussed on Gln transporters in breast cancer and TNBC. Methods The role and localisation of the Gln transporter SLC38A2/SNAT2 in response to Gln deprivatio...
4 CitationsSource