Thomas B. Lam
Aberdeen Royal Infirmary
CancerInternal medicineUrologySurgeryOncologyRandomized controlled trialIntensive care medicineSystematic reviewRenal cell carcinomaProstatectomyMEDLINEContext (language use)GuidelineProstate cancerNephrectomyBladder cancerKidney cancerClinical trialGeneral surgeryMedicineMeta-analysis
Publications 149
#1Ranan Dasgupta (Imperial College Healthcare)H-Index: 8
#2Sarah Cameron (Aberd.: University of Aberdeen)H-Index: 5
Last. Samuel McClinton (ARI: Aberdeen Royal Infirmary)H-Index: 26
view all 16 authors...
Abstract Background Renal stone disease is common and can cause emergency presentation with acute pain due to ureteric colic. International guidelines have stated the need for a multicentre randomised controlled trial (RCT) to determine whether a non-invasive outpatient (shockwave lithotripsy [SWL]) or surgical (ureteroscopy [URS]) intervention should be the first-line treatment for those needing active intervention. This has implications for shaping clinical pathways. Objective To report a prag...
2 CitationsSource
#1Lisa Moris (Katholieke Universiteit Leuven)H-Index: 11
#2Giorgio Gandaglia (UniSR: Vita-Salute San Raffaele University)H-Index: 47
Last. Ann Henry (St James's University Hospital)H-Index: 32
view all 26 authors...
Abstract null null Context null Surgical techniques aimed at preserving the neurovascular bundles during radical prostatectomy (RP) have been proposed to improve functional outcomes. However, it remains unclear if nerve-sparing (NS) surgery adversely affects oncological metrics. null null null Objective null To explore the oncological safety of NS versus non-NS (NNS) surgery and to identify factors affecting the oncological outcomes of NS surgery. null null null Evidence acquisition null Relevan...
#1Lisa MorisH-Index: 11
#2G. GandagliaH-Index: 3
Last. Thomas B. LamH-Index: 42
view all 24 authors...
#1Yasmin Abu-GhanemH-Index: 13
#2Thomas PowlesH-Index: 84
Last. Axel BexH-Index: 54
view all 17 authors...
Abstract Background Current follow-up strategies for patients with renal cell carcinoma (RCC) after curative surgery rely mainly on risk models and the treatment delivered, regardless of the histological subtype. Objective To determine the impact of RCC histological subtype on recurrence and to examine the incidence, pattern, and timing of recurrences to improve follow-up recommendations. Design, setting, and participants This study included consecutive patients treated surgically with curative ...
3 CitationsSource
#1Giuseppe FallaraH-Index: 3
#2Alessandro LarcherH-Index: 29
Last. Sergio Fernández-PelloH-Index: 9
view all 19 authors...
#1Anthony Simon Bates (ARI: Aberdeen Royal Infirmary)H-Index: 2
#2Jennifer Ayers (ARI: Aberdeen Royal Infirmary)H-Index: 2
Last. T.B. Lam (ARI: Aberdeen Royal Infirmary)H-Index: 5
view all 33 authors...
Abstract Context The clinical effectiveness of focal therapy (FT) for localised prostate cancer (PCa) remains controversial. Objective To analyse the evidence base for primary FT for localised PCa via a systematic review (SR) to formulate clinical practice recommendations. Evidence acquisition A protocol-driven, PRISMA-adhering SR comparing primary FT (sub-total, focal, hemi-gland, or partial ablation) versus standard options (active surveillance [AS], radical prostatectomy [RP], or external bea...
2 CitationsSource
#1Jens Bedke (DKFZ: German Cancer Research Center)H-Index: 31
#2Laurence Albiges (Université Paris-Saclay)H-Index: 58
Last. Axel Bex (Royal Free London NHS Foundation Trust)H-Index: 54
view all 18 authors...
The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naive metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination of lenvatinib plus pembrolizumab over sunitinib. The CheckMate-9ER trial update demonstrated an ongoing PFS, OS, a...
1 CitationsSource
#1Michael LardasH-Index: 10
#2Nikos Grivas (UoC: University of Crete)
Last. Nicolas MottetH-Index: 40
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Abstract Context While urinary incontinence (UI) commonly occurs after radical prostatectomy (RP), it is unclear what factors increase the risk of UI development. Objective To perform a systematic review of patient- and tumour-related prognostic factors for post-RP UI. The primary outcome was UI within 3 mo after RP. Secondary outcomes included UI at 3–12 mo and ≥12 mo after RP. Evidence acquisition Databases including Medline, EMBASE, and CENTRAL were searched between January 1990 and May 2020....
#1Thomas Van den Broeck (Katholieke Universiteit Leuven)H-Index: 21
#2Daniela E. Oprea-Lager (VU: VU University Amsterdam)H-Index: 14
Last. Nicolas MottetH-Index: 40
view all 27 authors...
CONTEXT The impact of surgeon and hospital volume on outcomes after radical prostatectomy (RP) for localised prostate cancer (PCa) remains unknown. OBJECTIVE To perform a systematic review on the association between surgeon or hospital volume and oncological and nononcological outcomes following RP for PCa. EVIDENCE ACQUISITION Medline, Medline In-Process, Embase, and the Cochrane Central Register of Controlled Trials were searched. All comparative studies for nonmetastatic PCa patients treated ...
2 CitationsSource
#1Yasmin Abu-Ghanem (Royal Free London NHS Foundation Trust)H-Index: 13
#2Thomas Powles (Lond: University of London)H-Index: 84
Last. Alex Bex (Royal Free London NHS Foundation Trust)H-Index: 1
view all 18 authors...
OBJECTIVE To investigate whether pT1-renal cell carcinoma (RCC) should be followed differently after partial (PN) or radical nephrectomy (RN) based on a retrospective analysis of a multi-centre database (RECUR). SUBJECTS Retrospective study of 3380 patients treated for nonmetastatic RCC between January-2006 and December-2011 across 15 centres from 10 countries, as part of the RECUR-database project. For patients with pT1 clear-cell RCC (ccRCC), patterns of recurrence were compared between RN and...