Dierdre Tatomer
University of California, San Francisco
Regulation of gene expressionEstrogen receptor alphaEstrogenTamoxifenSelective estrogen receptor modulatorCancer researchHormone response elementEstrogen receptorBiologyEstrogen receptor beta
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Estrogen receptors (ERs) regulate gene transcription by interacting with regulatory elements. Most information regarding how ER activates genes has come from studies using a small set of target genes or simple consensus sequences such as estrogen response element, activator protein 1, and Sp1 elements. However, these elements cannot explain the differences in gene regulation patterns and clinical effects observed with estradiol (E2) and selective estrogen receptor modulators. To obtain a greater...
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