Francesco Izzo
University of Kentucky
CancerInternal medicineRadiologySurgeryMagnetic resonance imagingOncologyImmunologyChemotherapyElectrochemotherapyCirrhosisRadiofrequency ablationBevacizumabHepatocellular carcinomaNuclear medicineIn patientCancer researchColorectal cancerMedicineBiologyGastroenterology
256Publications
48H-index
9,050Citations
Publications 264
Newest
#1Renato PatroneH-Index: 2
#2Nunzio Velotti (University of Naples Federico II)H-Index: 11
Last. Domenico Testa (Seconda Università degli Studi di Napoli)H-Index: 10
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Thyroid cancer is the most common endocrine malignancy, representing 2.9% of all new cancers in the United States. It has an excellent prognosis, with a five-year relative survival rate of 98.3%.Differentiated Thyroid Carcinomas (DTCs) are the most diagnosed thyroid tumors and are characterized by a slow growth rate and indolent course. For years, the only approach to treatment was thyroidectomy. Active surveillance (AS) has recently emerged as an alternative approach; it involves regular observ...
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#1Francesca PezzutoH-Index: 6
#2Francesco IzzoH-Index: 48
Last. Maria Lina TorneselloH-Index: 36
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Telomerase reactivation during hepatocarcinogenesis is recurrently caused by two point mutations occurring most frequently at the nucleotide −124 (95%) and occasionally at the nucleotide −146 ( A at position −124 and to quantify the mutant allele frequency (MAF) in 121 primary liver cancers, including 114 HCC along with 23 autologous cirrhotic tissues, five cholangiocarcinoma (CC), and two hepato-cholangiocarcinoma (HCC-CC). All cases were evaluated for tumour markers such as α-fetoprotein (AFP)...
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#1Vincenza GranataH-Index: 20
#2Roberta Grassi (Seconda Università degli Studi di Napoli)H-Index: 10
Last. Federica De Muzio (UNIMOL: University of Molise)
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This article provides an overview of diagnostic evaluation and ablation treatment assessment in Hepatocellular Carcinoma (HCC). Only studies, in the English language from January 2010 to January 202, evaluating the diagnostic tools and assessment of ablative therapies in HCC patients were included. We found 173 clinical studies that satisfied the inclusion criteria.HCC may be noninvasively diagnosed by imaging findings. Multiphase contrast-enhanced imaging is necessary to assess HCC. Intravenous...
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#1Antonio AvalloneH-Index: 3
Last. Antonino CassataH-Index: 3
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Importance null Although bevacizumab is a standard of care in combination treatments for metastatic colorectal cancer (mCRC), its clinical benefit has been limited. null Objective null To determine whether sequential scheduling of bevacizumab administration in combination with chemotherapy improves treatment efficacy in patients with mCRC, in keeping with the tumor vascular normalization hypothesis. null Design, Setting, and Participants null This open-label, randomized clinical phase 3 trial wa...
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#1Vincenza GranataH-Index: 20
#2Roberta Grassi (Seconda Università degli Studi di Napoli)H-Index: 10
Last. Francesco IzzoH-Index: 48
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BACKGROUND Currently, the technologies most commonly used to treat locally advanced pancreatic cancer are radiofrequency ablation (RFA), microwave ablation, and irreversible (IRE) or reversible electroporation combined with low doses of chemotherapeutic drugs. AIM To report an overview and updates on ablative techniques in pancreatic cancer. METHODS Several electronic databases were searched. The search covered the years from January 2000 to January 2021. Moreover, the reference lists of the fou...
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#1Aldo Rocca (UNIMOL: University of Molise)H-Index: 11
#2Federica Cipriani (UniSR: Vita-Salute San Raffaele University)H-Index: 27
Last. Luca AldrighettiH-Index: 59
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At the time of diagnosis synchronous colorectal cancer, liver metastases (SCRLM) account for 15-25% of patients. If primary tumour and synchronous liver metastases are resectable, good results may be achieved performing surgical treatment incorporated into the chemotherapy regimen. So far, the possibility of simultaneous minimally invasive (MI) surgery for SCRLM has not been extensively investigated. The Italian surgical community has captured the need and undertaken the effort to establish a Na...
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#1Vincenza GranataH-Index: 20
#2Roberta FuscoH-Index: 28
Last. Antonella PetrilloH-Index: 26
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BACKGROUND Radiomics is an emerging field and has a keen interest, especially in the oncology field. The process of a radiomics study consists of lesion segmentation, feature extraction, consistency analysis of features, feature selection, and model building. Manual segmentation is one of the most critical parts of radiomics. It can be time-consuming and suffers from variability in tumor delineation, which leads to the reproducibility problem of calculating parameters and assessing spatial tumor...
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Background: Imaging methods and the most appropriate criteria to be used for detecting and evaluating response to oncological treatments depend on the pathology and anatomical site to be treated and on the treatment to be performed. This document provides a general overview of the main imaging and histopathological findings of electroporation-based treatments (Electrochemotherapy—ECT and Irreversible electroporation—IRE) compared to thermal approach, such as radiofrequency ablation (RFA), in dee...
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Electroporation (EP) techniques, used alone (Irreversible Electroporation, IRE) or in combination with anti-cancer drugs (Electrochemotherapy, ECT), have been shown to be effective in the treatment of several types of cancers. The efficacy of ECT and IRE is well demonstrated for the treatment of non-superficial tumor metastases, and it depends on the applied electrical parameters. Particularly, ECT is an effective local therapy that uses electroporation to enhance the cytotoxic effect of bleomyc...
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Pancreatic ductal adenocarcinoma (PDAC) represents a challenge for a multidisciplinary oncology team. Diagnosis of PDAC remains challenging due to overlapping imaging features with benign lesions, notwithstanding great advances with computed tomography (CT) and magnetic resonance imaging (MRI). The term "Radiomics" has recently been introduced to define a mathematical process to extract countless quantitative features from medical images (including each diagnostic technique) with high throughput...
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