Scott L. Friedman
Icahn School of Medicine at Mount Sinai
Internal medicineEndocrinologyPathologyMolecular biologyHepatic stellate cellChemistryExtracellular matrixImmunologyLiver injuryCirrhosisHepatocellular carcinomaKLF6FibrosisHepatic fibrosisCancer researchMedicineCell cultureBiologyGastroenterologyCell biology
Publications 531
Abstract null Background & Aims null Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder with non-alcoholic steatohepatitis (NASH) being a more progressive phenotype associated with progression to cirrhosis. Type III collagen is a main component of the fibrotic extracellular matrix. PRO-C3 is a biomarker for detectison of moderate/severe fibrosis and the test is further improved when incorporated into the ADAPT algorithm. Here, we validated PRO-C3 and ADAPT within the CENTAUR sc...
#1Pablo Ranea-Robles (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
#2Hongjie Chen (Mount Sinai Hospital)H-Index: 2
Last. Sander M. Houten (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 64
view all 8 authors...
Peroxisomes metabolize a specific subset of fatty acids, which include dicarboxylic fatty acids (DCAs) generated by {omega}-oxidation. Data obtained in vitro suggest that the peroxisomal transporter ABCD3 (also known as PMP70) mediates the transport of DCAs into the peroxisome, but in vivo evidence to support this role is lacking. In this study, we studied an Abcd3 KO mouse model generated by CRISPR-Cas9 technology using targeted and untargeted metabolomics, histology, immunoblotting, and stable...
#1Paul Manka (University of Duisburg-Essen)H-Index: 15
#2Svenja Sydor (RUB: Ruhr University Bochum)H-Index: 11
Last. Anja Figge (RUB: Ruhr University Bochum)H-Index: 2
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Background and aims null An association between Crohn's disease (CD) and hepatic steatosis has been reported. However, the underlying mechanisms of steatosis progression in CD are not clear. Among the most effective CD-treatments are agents that inhibit Tumor-Necrosis-Factor (TNF) activity, yet it is unclear why anti-TNFα agents would affect steatosis in CD. Recent studies suggest that microbiome can affect both, CD and steatosis pathogenesis. Therefore, we here analyzed a potential relationship...
#1Gabriela Hernandez-Meza (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 6
#2Naik Vietti Violi (UNIL: University of Lausanne)H-Index: 8
Last. Paolo Boffetta (SBU: Stony Brook University)H-Index: 171
view all 12 authors...
PURPOSE In this study, we describe the patterns of hepatocellular carcinoma (HCC) screening with imaging and factors associated with imaging modality selection in a tertiary care transplant center. METHODS This was a retrospective study where all adult patients with cirrhosis and/or chronic hepatitis B virus infection referred for HCC screening with ultrasound (US), CT or MRI were identified during 2017. The association between imaging methods, demographic/clinical data were analyzed by uni- and...
#1Laura Torrens (University of Barcelona)H-Index: 1
#2Carla Montironi (University of Barcelona)H-Index: 9
Last. Jordi Abril-Fornaguera (University of Barcelona)H-Index: 1
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BACKGROUND & AIMS Lenvatinib is an effective drug in advanced hepatocellular carcinoma (HCC). Its combination with the anti-PD1 immune checkpoint inhibitor pembrolizumab has generated encouraging results in phase Ib and is currently being tested in phase III trials. Here, we aimed to explore the molecular and immunomodulatory effects of lenvatinib alone or in combination with anti-PD1. APPROACH & RESULTS We generated three syngeneic models of HCC in C57BL/6J mice (subcutaneous and orthotopic) an...
1 CitationsSource
#1Gene Y. Im (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 15
#2Alexander S. Vogel (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Thomas D. Schiano (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 64
view all 10 authors...
BACKGROUND AND AIMS Early liver transplantation (LT) for severe alcoholic hepatitis (AH) is a rescue therapy for highly selected patients with favorable psychosocial profiles not responding to medical therapy. Given the expected increase of AH candidate referrals requiring complex care and comprehensive evaluations, increased workload and cost might be expected from implementing an early LT program for AH, but have not been determined. Some centers may also view AH as a strategy to expeditiously...
#1James K. Carter (ISMMS: Icahn School of Medicine at Mount Sinai)
#2Shuang Wang (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
Last. Scott L. Friedman (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 142
view all 3 authors...
Heterogeneity among hepatic stellate cells (HSCs), widely acknowledged as the 'stars' of hepatic fibrosis, has been hinted at for decades based on immunohistochemical methods. Now, more refined approaches, epitomized by the studies of Rosenthal et al. in this issue of Hepatology, have amplified this concept. Earlier investigators noted striking variability across the hepatic lobule in hallmark features of HSCs including vitamin A storage and dendritic arborization -- indications that not every H...
#1Pablo Ranea-Robles (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
#2Sara Violante (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 13
Last. Sander M. Houten (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 64
view all 10 authors...
Peroxisomes play an essential role in the β-oxidation of dicarboxylic acids (DCAs), which are metabolites formed upon ω-oxidation of fatty acids. Genetic evidence linking transporters and enzymes to specific DCA β-oxidation steps is generally lacking. Moreover, the physiological functions of DCA metabolism remain largely unknown. In this study, we aimed to characterize the DCA β-oxidation pathway in human cells, and to evaluate the biological role of DCA metabolism using mice deficient in the pe...
4 CitationsSource
#1Stefanie J. Hectors (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 16
#2Paul Kennedy (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 7
Last. Bachir Taouli (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 59
view all 8 authors...
To (1) develop a fully automated deep learning (DL) algorithm based on gadoxetic acid–enhanced hepatobiliary phase (HBP) MRI and (2) compare the diagnostic performance of DL vs. MR elastography (MRE) for noninvasive staging of liver fibrosis. This single-center retrospective study included 355 patients (M/F 238/117, mean age 60 years; training, n = 178; validation, n = 123; test, n = 54) who underwent gadoxetic acid–enhanced abdominal MRI, including HBP and MRE, and pathological evaluation of th...
6 CitationsSource
#1Roser Pinyol (University of Barcelona)H-Index: 13
#2Sara Torrecilla (University of Barcelona)H-Index: 6
Last. Josep M. Llovet (Catalan Institution for Research and Advanced Studies)H-Index: 120
view all 35 authors...
Abstract Background and Aims Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We aimed to identify unique molecular traits characterizing NASH-HCC compared to other HCC aetiologies. Methods We collected 80 NASH-HCC and 125 NASH samples from 5 institutions. Expression array (n=53 NASH-HCC; n=74 NASH) and whole exome sequencing (n=52 NASH-HCC) data were compared to HCCs of other aetiologies (n=184)....
1 CitationsSource