Jean-Luc Reny
Geneva College
Internal medicineEndocrinologySurgeryOdds ratioCardiologyIntensive care medicineProspective cohort studyImmunologyAntiplatelet drugAspirinAcute coronary syndromeClopidogrelPneumoniaDiseaseMEDLINEThrombosisPopulationGynecologyP2Y12Diabetes mellitusMedicineBiologyPlateletGastroenterologyPharmacology
Publications 208
#2Jean-Luc RenyH-Index: 32
Last. Pascal BonnabryH-Index: 25
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#1Antonio Leidi (Geneva College)H-Index: 3
#2Antoine Saudan (Geneva College)
Last. Olivier Grosgurin (Geneva College)H-Index: 10
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Physical examination (PE) has always been a corner stone of medical practice. The recent advances in imaging and fading of doctors' ability in performing it, however, raised doubts on PE usefulness. Point-of-care ultrasonography (POCUS) is gaining ground in medicine with the detection of free fluids being one of its main applications. To estimate physicians' confidence and use of PE and POCUS for the detection of abdominal or pleural free fluid, we conducted a cross-sectional survey. In all, 246...
#1Olivier Grosgurin (Geneva College)H-Index: 10
#2Antonio Leidi (Geneva College)H-Index: 3
Last. Christophe Marti (Geneva College)H-Index: 10
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BACKGROUND: The COVID-19 pandemic has led to shortage of intensive care unit (ICU) capacity. We developed a triage strategy including noninvasive respiratory support and admission to the intermediate care unit (IMCU). ICU admission was restricted to patients requiring invasive ventilation. OBJECTIVES: The aim of this study is to describe the characteristics and outcomes of patients admitted to the IMCU. METHOD: Retrospective cohort including consecutive patients admitted between March 28 and Apr...
#1Alix Garcia (University of Geneva)H-Index: 3
#2Sylvie Dunoyer-Geindre (University of Geneva)H-Index: 16
Last. Pierre Fontana (University of Geneva)H-Index: 31
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BACKGROUND Several platelet-derived miRNAs are associated with platelet reactivity (PR) and clinical outcome in cardiovascular patients. We previously showed an association between miR-204-5p and PR in stable cardiovascular patients, but data on functional mechanisms are lacking. AIMS To validate miR-204-5p as a regulator of PR in platelet-like structures (PLS) derived from human megakaryocytes and to address mechanistic issues. METHODS Human hematopoietic stem cells were differentiated into meg...
#1Terrier Jean (University of Geneva)
#1Jean Terrier (University of Geneva)H-Index: 4
Last. Caroline Flora Samer (Geneva College)H-Index: 22
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Even though direct oral anticoagulants (DOAC) are at risk for drug-drug interactions, they are barely mentioned in the dose adjustment guidelines and contradictory information is found in the summary of product characteristics of individual DOACs. This represents a significant issue for general and internal medicine clinicians, as it is well established that patients with atrial fibrillation receive numerous co-medications, and that polymedication increases the bleeding risk. Our multidisciplina...
Platelet reactivity (PR), a key pharmacodynamic (PD) component of the action of antiplatelet drugs in cardiovascular disease (CVD) patients, is highly variable. PR is associated with occurrence or recurrence of thrombotic and bleeding events, but this association is modulated by several factors. Conventional pharmacogenetics explains a minor part of this PR variability, and among determinants of PR, circulating microRNAs (miRNAs) have been the focus of attention during these last years as biomar...
#1Diego O AndreyH-Index: 13
#2Sabine YerlyH-Index: 68
Last. Nicolas VuilleumierH-Index: 30
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Purpose: To assess the diagnostic performances of five automated anti-SARS-CoV-2 immunoassays, Epitope (N), Diasorin (S1/S2), Euroimmun (S1), Roche N (N), and Roche S (S-RBD), and to provide a testing strategy based on pre-test probability. Methods: We assessed the receiver operating characteristic (ROC) areas under the curve (AUC) values, along with the sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs), of each assay using a validation sample set...
#1Christian Skalafouris (Geneva College)
#1C. Skalafouris (Geneva College)
Last. B. Guignard (Geneva College)H-Index: 7
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During Switzerland's first wave of COVID-19, clinical pharmacy activities during medical rounds in Geneva University Hospitals were replaced by targeted remote interventions. We describe using the electronic PharmaCheck system to screen high-risk situations of adverse drug events (ADEs), particularly targeting prescriptions of lopinavir/ritonavir (LPVr) and hydroxychloroquine (HCQ) in the presence of contraindications or prescriptions outside institutional guidelines. Of 416 patients receiving L...
#1Alix Garcia (University of Geneva)H-Index: 3
#2Sylvie Dunoyer-Geindre (University of Geneva)H-Index: 16
Last. Pierre Fontana (Geneva College)H-Index: 31
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MicroRNAs (miRNAs) are small noncoding RNAs modulating protein production. They are key players in regulation of cell function and are considered as biomarkers in several diseases. The identification of the proteins they regulate, and their impact on cell physiology, may delineate their role as diagnostic or prognostic markers and identify new therapeutic strategies. During the last 3 decades, development of a large panel of techniques has given rise to multiple models dedicated to the study of ...
5 CitationsSource
Background and importance In the internal medicine department of our hospital, medication review provided by pharmacists during medical rounds is offered to only a fraction of the 200 inpatients, due to limited resources. In order to detect high risk situations potentially leading to adverse drug events, we developed PharmaCheck, an electronic tool that screens all patient electronic health records (EHR) in real time, by aggregating drug prescriptions, laboratory values, vital signs and medical ...