Juliano Ferreira
Universidade Federal de Santa Catarina
Internal medicineEndocrinologyNociceptionTRPV1ReceptorChemistryKininAntagonistNeuropathic painAllodyniaReceptor antagonistAgonistHyperalgesiaCapsaicinAnalgesicAnesthesiaBiochemistryMedicineBiologyPharmacology
210Publications
54H-index
7,436Citations
Publications 190
Newest
#1Diéssica Padilha Dalenogare (UFSM: Universidade Federal de Santa Maria)H-Index: 7
#2Camila Duarte Ritter (UFSM: Universidade Federal de Santa Maria)H-Index: 10
Last. Juliano Ferreira (UFSC: Universidade Federal de Santa Catarina)H-Index: 54
view all 0 authors...
Headaches are frequently described in progressive multiple sclerosis (PMS) patients, but their mechanism remains unknown. Transient receptor potential ankyrin 1 (TRPA1) was involved in neuropathic nociception in a model of PMS induced by experimental autoimmune encephalomyelitis (PMS-EAE), and TRPA1 activation causes periorbital and facial nociception. Thus, our purpose was to observe the development of periorbital mechanical allodynia (PMA) in a PMS-EAE model and evaluate the role of TRPA1 in p...
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#1Diulle Spat Peres (UFSM: Universidade Federal de Santa Maria)H-Index: 2
#2Maria Carolina Theisen (UFSM: Universidade Federal de Santa Maria)H-Index: 2
Last. Tuane Bazanella Sampaio (UFSM: Universidade Federal de Santa Maria)H-Index: 12
view all 17 authors...
Abstract null null Progressive multiple sclerosis (PMS) is a neurological disease associated with the development of depression and anxiety, but treatments available are unsatisfactory. The transient receptor potential ankyrin 1 (TRPA1) is a cationic channel activated by reactive compounds, and the blockage of this receptor can reduce depression- and anxiety-like behaviors in naive mice. Thus, we investigated the role of TRPA1 in depression- and anxiety-like behaviors in a PMS model in mice. PMS...
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Abstract Opioids are the first-line treatment for cancer pain. Incomplete pain relief and the high rate of adverse effects of these compounds bring a need to combine them with other drugs acting on different targets. Aims We here evaluate the antinociceptive interaction and adverse events of methadone combined with recombinant Phα1β, an analgesic toxin from Phoneutria nigriventer. Main methods Melanoma was produced by intraplantar inoculation of B16-F10 cells into the right paw. von Frey filamen...
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#1Jonathan Paulo Agnes (UFSC: Universidade Federal de Santa Catarina)H-Index: 3
#2Vitória Wibbelt dos Santos (UFSC: Universidade Federal de Santa Catarina)H-Index: 2
Last. Alfeu Zanotto-Filho (UFSC: Universidade Federal de Santa Catarina)H-Index: 25
view all 16 authors...
Abstract Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common, difficult-to-treat, and dose-limiting side effect associated with Oxaliplatin (OXA) treatment. In this study, we evaluated the effect of three antioxidants - namely N-acetylcysteine, α-lipoic acid and vitamin E – upon nociceptive parameters and antitumor efficacy of OXA in a tumor-bearing Swiss mice model. Oral treatment with antioxidants inhibited both mechanical and cold allodynia when concomitantly administrated with OXA ...
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#1Marcella de Amorim Ferreira (UFSC: Universidade Federal de Santa Catarina)H-Index: 2
#2Débora Denardin Lückemeyer (UFSC: Universidade Federal de Santa Catarina)H-Index: 10
Last. Juliano Ferreira (UFSC: Universidade Federal de Santa Catarina)H-Index: 54
view all 8 authors...
Abstract Central sensitization (CS) is characteristic of difficult to treat painful conditions, such as fibromyalgia and neuropathies and have sexual dimorphism involved. The calcium influx in nociceptive neurons is a key trigger for CS and the role of Cav2.1 and Cav2.2 voltage gated calcium channels (VGCC) in this role were evidenced with the use of ω-agatoxin IVA and ω-agatoxin MVIIA blockers, respectively. However, the participation of the α1 subunit of the voltage-gated channel Cav2.3, which...
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Rheumatoid arthritis (RA) is a painful inflammatory disease of the joints which affects a considerable proportion of the world population, mostly women. If not adequately treated, RA patients can become permanently disabled. Importantly, not all the patients respond to the available anti-rheumatic therapies, which also present diverse side effects. In this context, monitoring of treatment response is pivotal to avoid unnecessary side effects and costs towards an ineffective therapy. Herein, we p...
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#1Juliano FerreiraH-Index: 54
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#1Juliano FerreiraH-Index: 54
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#1Raquel Tonello (UFSC: Universidade Federal de Santa Catarina)H-Index: 18
#2Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 28
Last. Juliano Ferreira (UFSC: Universidade Federal de Santa Catarina)H-Index: 54
view all 6 authors...
Abstract Opioids are the “gold standard” treatment for postoperative pain, but these drugs also have limiting adverse effects. Thus, adjuvant drugs might be useful in opioid therapy for postoperative pain. The aim of the present study was to evaluate the effect of Phα1β, a dual blocker of Cav2 and TRPA1 channels, on antinociceptive and adverse actions of morphine in a model of postoperative pain. Phα1β (100–300 pmol/site) or morphine (3–10 mg/kg), alone, largely reduced postoperative nociception...
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#1Indiara Brusco (UFSM: Universidade Federal de Santa Maria)H-Index: 11
#2Simone Li Puma (UniFI: University of Florence)H-Index: 9
Last. Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 28
view all 15 authors...
: Antineoplastic therapy has been associated with pain syndrome development characterized by acute and chronic pain. The chemotherapeutic agent dacarbazine, used mainly to treat metastatic melanoma, is reported to cause painful symptoms, compromising patient quality of life. Evidence has proposed that transient receptor potential ankyrin 1 (TRPA1) plays a critical role in chemotherapy-induced pain syndrome. Here, we investigated whether dacarbazine causes painful hypersensitivity in naive or mel...
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