Kalpana Gupta
Case Western Reserve University
Internal medicineSurgeryInfection controlRetrospective cohort studyIntensive care medicinePediatricsEmergency medicineVeterans AffairsMethicillin-resistant Staphylococcus aureusAntibiotic prophylaxisStaphylococcus aureusConfidence intervalAntimicrobialAntibioticsMedicineUrinary systemBiologyMicrobiologyAntibiotic resistance
Publications 191
#1William O’BrienH-Index: 10
Last. Kamal M.F. ItaniH-Index: 64
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#2William O’BrienH-Index: 10
Last. Kamal M.F. Itani (Harvard University)H-Index: 64
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Background: It is unclear if a history of mesh explantation for infection is predictive of future microbiology after subsequent hernia operations. We investigated how often the same causative organism is cultured in the initial explantation and subsequent repairs. Patients and Methods: We obtained data on patients undergoing ventral/incisional, umbilical, and inguinal hernia repairs from the Veterans Affairs Surgical Quality Improvement Program during 2008-2015. Manual review was performed for a...
#1Katherine Linsenmeyer (VA Boston Healthcare System)H-Index: 5
#2Kalpana Gupta (VA Boston Healthcare System)H-Index: 46
Last. Michael E. Charness (VA Boston Healthcare System)H-Index: 40
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Abstract null Background null Recent reports indicate that vaccination is effective in reducing symptomatic infection with the Delta variant of SARS-CoV-2 (DV) but is less protective against asymptomatic transmission of DV in outpatients than for earlier variants. null Here we report cryptic transmission associated with high DV viral load among vaccinated patients on an inpatient medical-surgical ward. null Methods null This observational study included all persons diagnosed with breakthrough SA...
#1Lindsay Stetson (Case Western Reserve University)H-Index: 9
#2Dheepa Balasubramanian (Case Western Reserve University)H-Index: 5
Last. Robert Schauner (Case Western Reserve University)H-Index: 1
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The prognosis of most patients with AML is poor due to frequent disease relapse. The cause of relapse is thought to be from the persistence of leukemia initiating cells (LIC's) following treatment. Here we assessed RNA based changes in LICs from matched patient diagnosis and relapse samples using single-cell RNA sequencing. Previous studies on AML progression have focused on genetic changes at the DNA mutation level mostly in bulk AML cells and demonstrated the existence of DNA clonal evolution....
1 CitationsSource
#1Sheelarani Karunanithi (Case Western Reserve University)H-Index: 8
#2Ruifu Liu (Case Western Reserve University)H-Index: 3
Last. Satwikreddy Putluri (BCM: Baylor College of Medicine)
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Despite the fact that AML is the most common acute leukemia in adults, patient outcomes are poor necessitating the development of novel therapies. We identified that inhibition of Thioredoxin Reductase (TrxR) is a promising strategy for AML and report a highly potent and specific inhibitor of TrxR, S-250. Both pharmacologic and genetic inhibition of TrxR impairs the growth of human AML in mouse models. We found that TrxR inhibition leads to a rapid and marked impairment of metabolism in leukemic...
Background: Studies of antibiotic prescribing choice and duration have typically excluded women with recurrent UTI (rUTI), yet the Infectious Disease Society of America (IDSA) UTI treatment guidelines are applicable to recurrent and sporadic cystitis. We sought to better understand prescribing practices among uncomplicated rUTI patients in terms of choice of drug, duration of therapy, and the risk factors for receiving guideline-discordant therapy. Methods: We performed a retrospective database ...
#1Kelly Cho (VA: United States Department of Veterans Affairs)
#2Sarah C Keithly (VA: United States Department of Veterans Affairs)
Last. Yuk-Lam Ho (VA: United States Department of Veterans Affairs)H-Index: 10
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Background null Early convalescent plasma transfusion may reduce mortality in patients with non-severe coronavirus disease 2019 (COVID-19). null Methods null This study emulates a (hypothetical) target trial using observational data from a cohort of United States Veterans admitted to a Department of Veterans Affairs (VA) facility between May 1 and November 17, 2020 with non-severe COVID-19. The intervention was convalescent plasma initiated within 2 days of eligibility. Thirty-day mortality was ...
1 CitationsSource
3 CitationsSource
#1Kalpana Gupta (VA Boston Healthcare System)H-Index: 46
#2Pamela Bellino (VA Boston Healthcare System)H-Index: 1
Last. Michael E. Charness (VA Boston Healthcare System)H-Index: 40
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15 CitationsSource
#1Zachary Jackson (Case Western Reserve University)H-Index: 1
#2Changjin Hong (Cleveland Clinic Lerner Research Institute)H-Index: 9
Last. David N. Wald (Veterans Health Administration)H-Index: 20
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Chimeric antigen receptor T cell (CAR-T cell) therapy is known to produce durable remissions in the treatment of CD19+ relapsed/refractory B cell malignancies. Nonetheless, a significant portion of patients receiving the therapy experience poor outcomes in the acute response for unknown reasons. Given the decreased expansion and persistence of CD8 CAR-T cells in poor outcome groups, this failure may be attributed to CAR-T cell dysfunction. However, a comparison of the post-infusion transcription...