M Carrara
University of Pisa
AirwayInternal medicineCross-sectional studyImmunologyAllergyFEV1/FVC ratioPlaceboLung volumesAsthmaBronchial hyperresponsivenessHigh-resolution computed tomographyAtopyChronic coughSilicosisPhlegmOccupational asthmaAllergenMethacholineNuclear medicineChronic bronchitisBronchial provocationRadiographyGold standard (test)AnesthesiaFunctional residual capacityMedicinePulmonary function testingEnvironmental health
14Publications
6H-index
236Citations
Publications 13
Newest
#1D TaliniH-Index: 13
#1D. TaliniH-Index: 6
Last. Pier Luigi PaggiaroH-Index: 1
view all 4 authors...
OBJECTIVE: To evaluate the prevalence of respiratory symptoms in agricultural workers in a rural area of Tuscany and to relate them to some occupational risk factors. SUBJECTS AND METHODS: A cross sectional study was performed on a sample of 461 agricultural workers from two rural area of Tuscany. All subjects underwent to respiratory questionnaire, pulmonary function test and skin prick tests. Occupational risk factors were evaluated as response to questions related to 11 specific jobs, most of...
6 Citations
#1D TaliniH-Index: 13
#2A. Benvenuti (UniPi: University of Pisa)H-Index: 2
Last. P.L. Paggiaro (UniPi: University of Pisa)H-Index: 14
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Abstract The diagnosis of occupational asthma is usually performed in epidemiology using a combination of symptoms and bronchial hyperresponsiveness, while in a clinical setting the ‘gold standard' for the diagnosis of occupational asthma is the specific bronchial challenge test in the laboratory. The aim of this study was to detect new cases of flour-induced occupational asthma (OA) in a group of workers exposed to grain and/or flour dust, by means of a step-by-step approach, as used in a clini...
35 CitationsSource
#1Am Carletti (UniPi: University of Pisa)H-Index: 1
#2D. TaliniH-Index: 6
Last. Pierluigi PaggiaroH-Index: 48
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: The gold standard in the diagnosis of occupational asthma is the specific bronchial provocation test (sBPT), but other diagnostic criteria have been proven to have a similar sensitivity, mainly in asthma due to high molecular weight compounds. In order to assess wether some clinical findings can predict the positive response to sBPT, we studied 37 subjects (14 millers and 23 bakers) with suspected occupational asthma who underwent sBPT with wheat flour dust (dust exposure in a small cabin: geo...
4 Citations
#1Fabio FalaschiH-Index: 24
#2L BattollaH-Index: 12
Last. C. BartolozziH-Index: 28
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: To compare the usefulness of high-resolution computed tomography (HRCT) and chest radiography in the functional evaluation of silica-exposed workers, 27 workers were submitted to posteroanterior and lateral chest radiographs, apex to base HRCT scans and pulmonary function tests. Two experienced readers studied plain films independently to assess small opacities profusion (ILO-UC, Geneva 1980): from 0/- to 3/+. HRCT grading and extent of silicotic nodules and associated emphysema were scored on...
5 Citations
#1D Talini (UniPi: University of Pisa)H-Index: 13
#2Pierluigi PaggiaroH-Index: 48
Last. C. GiuntiniH-Index: 2
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OBJECTIVES--To compare the usefulness of high resolution computed tomography (HRCT) with chest radiography (CR) in the diagnosis and assessment of severity of silicosis. METHODS--27 workers exposed to silica underwent CR, HRCT, and pulmonary function tests. Two experienced readers independently evaluated CR by International Labour Office classification, and grouped the results into four categories. HRCT categories of nodule profusion and the extent of emphysema were graded on a four point scale;...
28 CitationsSource
#1Barbara VagagginiH-Index: 28
#2P.L. PaggiaroH-Index: 14
Last. C. GiuntiniH-Index: 4
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: In order to assess whether treatment with oral slow-release theophylline prevents early (EAR) and/or late (LAR) airway responses to allergen, we treated six asthmatic subjects with either placebo or oral theophylline (350 mg b.i.d.) for one week before specific bronchial provocation test (sBPT) with allergen, in a double-blind, cross-over, placebo-controlled study. All subjects had previously shown both EAR and LAR to allergen sBPT. On the day of sBPT, serum theophylline concentration was > 9 ...
#1P.L. PaggiaroH-Index: 14
#2D GianniniH-Index: 22
Last. M PetrozzinoH-Index: 3
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: The role of peak expiratory flow (PEF) monitoring in the diagnosis of occupational asthma has recently been assessed by several studies, which agree that this procedure should always be used to confirm the relationship between symptoms and occupational exposure. Some specific issues should be satisfied: a minimum number of four PEF measurements in a day; several weeks of monitoring in and out of work; and the presence of specific patterns of PEF changes. The sensitivity and specificity of PEF ...
#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 48
#2Barbara VagagginiH-Index: 28
Last. Carlo GiuntiniH-Index: 46
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Several studies on the prognosis of occupational asthma have shown that a significant proportion of patients continue to experience asthmatic symptoms and nonspecific bronchial hyperresponsiveness after cessation of work. The determinants of this unfavourable prognosis of asthma are: long duration of exposure before the onset of asthma; long duration of symptoms before diagnosis; baseline airway obstruction; dual response after specific challenge test; and the persistence of markers of airway in...
87 CitationsSource
#1P.L. Paggiaro (UniPi: University of Pisa)H-Index: 14
#2Fl DenteH-Index: 19
Last. Barbara VagagginiH-Index: 28
view all 10 authors...
: In order to investigate if bronchial asthma is associated with enhanced markers of activation in peripheral neutrophils, the migratory capacity of neutrophils in venous blood was measured by means of the Boyden chamber technique in 29 subjects with bronchial asthma of differing severity. Random migration (random motility), but not locomotion toward 10% Escherichia coli supernatant as chemoattractant (chemotaxis), was increased in asthmatic subjects with respect to 11 normal subjects (98 +/- 20...
2 Citations
#1Pierluigi Paggiaro (UniPi: University of Pisa)H-Index: 48
#2Barbara Vagaggini (UniPi: University of Pisa)H-Index: 28
Last. Carlo Giuntini (UniPi: University of Pisa)H-Index: 46
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Long-term change in nonspecific and specific bronchial hyperresponsiveness was studied in 16 subjects with asthma induced by toluene diisocyanate (TDI). A significant positive correlation between months of follow-up and provocative dose inducing a 20 percent fall in FEV 1 (PD 20 FEV 1 ) methacholine was observed in 5 of 16 subjects. In 4 of these 5 subjects, a PD 20 FEV 1 >1 mg of methacholine was observed 30 to 48 months after the end of TDI exposure. In most subjects, nonspecific bronchial hyp...
54 CitationsSource