Mike Seed
University of Toronto
Internal medicineRadiologyPathologyMagnetic resonance imagingBlood flowCardiologyFetusHemodynamicsGreat arteriesTetralogy of FallotVentriclePregnancyFetal circulationHeart diseaseNuclear medicineMyocardial fibrosisAnesthesiaAngiologyMedicine
Publications 205
#1Grace M. McBride (UniSA: University of South Australia)
#2Ashley S. Meakin (UniSA: University of South Australia)
Last. Christopher K. Macgowan (U of T: University of Toronto)H-Index: 27
view all 14 authors...
Abstract null null Purpose null Ten percent of pregnancies are affected by intrauterine growth restriction (IUGR), and evidence suggests that affected neonates have reduced activity of hepatic cytochrome P450 (CYP) drug metabolising enzymes. Given that almost all pregnant individuals take medications and additional medications are often required during an IUGR pregnancy, we aimed to determine the impact of IUGR on hepatic CYP activity in sheep fetuses and pregnant ewes. null null null Methods nu...
#1Safwat Aly (U of T: University of Toronto)H-Index: 3
#2Koyelle Papneja (U of T: University of Toronto)
Last. Shi-Joon Yoo (U of T: University of Toronto)H-Index: 33
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BACKGROUND The impact of fetal echocardiography on the diagnosis and outcomes of vascular ring has not been well examined. We hypothesized that prenatal detection of vascular ring has improved over time and that prenatal diagnosis of vascular ring is associated with earlier intervention and favorable outcomes. METHODS This is a single-center, retrospective study of the evolution and outcomes of prenatal diagnosis of vascular ring from 2000 to 2020. We compared clinical presentation, timing of su...
#1Jiaqi Ren (UniSA: University of South Australia)H-Index: 2
#2Jack R. T. Darby (UniSA: University of South Australia)H-Index: 10
Last. Christopher K. MacgowanH-Index: 27
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Key points null Maternal undernutrition during gestation alters fetal lung development by impacting surfactant maturation. However, the direction of change remains controversial. We examined the effects of maternal late gestation maternal undernutrition (LGUN) on maternal and fetal outcomes, signaling pathways involved in fetal lung development, pulmonary hemodynamics and oxygen delivery in sheep using a combination of molecular and MRI techniques. LGUN decreased fetal plasma glucose concentrati...
#1Catherine G. Dimasi (UniSA: University of South Australia)
#2Joanna Lazniewska (UniSA: University of South Australia)H-Index: 14
Last. Mike Seed (U of T: University of Toronto)H-Index: 23
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Intrauterine growth restriction (IUGR) is a result of limited substrate supply to the developing fetus in utero, and can be caused by either placental, genetic or environmental factors. Babies born IUGR can have poor long-term health outcomes, including being at higher risk of developing cardiovascular disease. Limited substrate supply in the IUGR fetus not only changes the structure of the heart but may also affect metabolism and function of the developing heart. We have utilised two imaging mo...
#1Anum Rahman (U of T: University of Toronto)H-Index: 5
Last. John G. SledH-Index: 56
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In hypoplastic left heart syndrome (HLHS), the mechanisms leading to left heart hypoplasia and their associated fetal abnormalities are largely unknown. Current animal models have limited utility in resolving these questions as they either do not fully reproduce the cardiac phenotype, do not survive to term, and/or have very low disease penetrance. Here, we report the development of a surgically-induced mouse model of HLHS that overcomes these limitations. Briefly, we microinjected the fetal lef...
#1Eric M. SchraubenH-Index: 10
#2Jack R. T. Darby (Group Health Cooperative)H-Index: 10
Last. Steven K. S. Cho (Group Health Cooperative)H-Index: 1
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The ductus arteriosus (DA) functionally closes during the transition from fetal to postnatal life because of lung aeration and corresponding cardiovascular changes. The thorough and explicit measurement and visualization of the right and left heart output during this transition has not been previously accomplished. We combined 4D flow MRI (dynamic volumetric blood flow measurements) and T2 relaxometry (oxygen delivery quantification) in surgically instrumented newborn piglets to assess the DA. T...
#1Shabnam Peyvandi (UCSF: University of California, San Francisco)H-Index: 12
#2Jessie Mei Lim (U of T: University of Toronto)H-Index: 4
Last. Mike Seed (U of T: University of Toronto)H-Index: 23
view all 9 authors...
Abstract Objective To test the hypothesis that delayed brain development in fetuses with d-transposition of the great arteries or hypoplastic left heart syndrome heightens their postnatal susceptibility to acquired white matter injury. Methods This is a cohort study across 3 sites. Subjects underwent fetal (third trimester) and neonatal preoperative magnetic resonance imaging of the brain to measure total brain volume as a measure of brain maturity and the presence of acquired white matter injur...
5 CitationsSource
#1K Gill (U of T: University of Toronto)
#2N Arbic (U of T: University of Toronto)
Last. Edgar Jaeggi (U of T: University of Toronto)H-Index: 49
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We report a fetal case of Ebstein's anomaly with severe tricuspid regurgitation, functional pulmonary atresia and progressive circular shunting (CS) across a widely patent ductus arteriosus (DA) and regurgitant pulmonary valve, contributing to significant systemic hypoperfusion. To mitigate the amount of CS and allow the pregnancy to continue, maternal non-steroidal anti-inflammatory drug (NSAID) therapy with indomethacin was started at 33+5 weeks to induce DA constriction. Rather than the desir...
#2Jiawei XuH-Index: 2
Last. Christopher K. MacgowanH-Index: 27
view all 8 authors...
Fetal development relies on a complex circulatory network and accurately assessing the flow distribution is important for understanding pathologies and potential therapies. In this paper, we demonstrate a method for volumetric multidimensional imaging of fetal flow with magnetic resonance imaging (MRI). Fetal application of MRI faces several challenges such as small vascular structures, unpredictable motion, and lack of traditional cardiac gating methods. Here, orthogonal multislice stacks are a...
#1Fu-Tsuen LeeH-Index: 2
#2Davide MariniH-Index: 8
Last. Liqun SunH-Index: 7
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2 CitationsSource