Francine Tesser-Gamba
Federal University of São Paulo
GeneCancerInternal medicineMAPK7PathologyOncologyGene expressionOsteosarcomaMetastasisTumor progressionPediatric oncologyCancer researchCarcinogenesisMAPK/ERK pathwayBioinformaticsSignal transductionMedicineBiology
10Publications
4H-index
56Citations
Publications 13
Newest
#1Débora Cabral de Carvalho Corrêa (UNIFESP: Federal University of São Paulo)H-Index: 1
#2Francine Tesser-Gamba (UNIFESP: Federal University of São Paulo)H-Index: 4
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 21
view all 9 authors...
Gliomas represent the most frequent central nervous system (CNS) tumors in children and adolescents. However, therapeutic strategies for these patients, based on tumor molecular profile, are still limited compared to the wide range of treatment options for the adult population. We investigated molecular alterations, with a potential prognostic marker and therapeutic target in gliomas of childhood and adolescence using the next-generation sequencing (NGS) strategy. We selected 95 samples with ini...
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#1G.M. Guimarães (UNIFESP: Federal University of São Paulo)
#2Francine Tesser-Gamba (UNIFESP: Federal University of São Paulo)H-Index: 4
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 21
view all 9 authors...
Abstract null null Osteosarcoma (OS) is a malignant bone tumor, with a peak of incidence in the second decade of life and possibly associated with the presence of germline mutations. Besides, clinicians have pointed to a second, rarer group of patients that develops OS before 10 years old. Here we access, through next-generation sequencing (NGS) strategy, the genetic alterations present in OS and blood samples from patients diagnosed before and during the second decade of life. A custom NGS pane...
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#1Débora Cabral de Carvalho Corrêa (UNIFESP: Federal University of São Paulo)H-Index: 1
#2Francine Tesser-Gamba (UNIFESP: Federal University of São Paulo)H-Index: 4
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 21
view all 10 authors...
Ependymoma (EPN) accounts for approximately 10% of all primary central nervous system (CNS) tumors in children and in most cases, chemotherapy is ineffective and treatment remains challenging. We investigated molecular alterations, with a potential prognostic marker and therapeutic target in EPNs of childhood and adolescence, using a next-generation sequencing (NGS) panel specific for pediatric neoplasms. We selected 61 samples with initial diagnosis of EPN from patients treated at Pediatric Onc...
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Last. Silvia Regina ToledoH-Index: 3
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Last. Silvia Regina Toledo (UNIFESP: Federal University of São Paulo)H-Index: 3
view all 7 authors...
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#1Francine Tesser-Gamba (UNIFESP: Federal University of São Paulo)H-Index: 4
#2Alini Trujillo Paolillo (UNIFESP: Federal University of São Paulo)H-Index: 1
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 21
view all 7 authors...
Abstract Osteosarcoma (OS) is a class of cancer originating from the bone, affecting mainly children and young adults. Our previous study showed that MAPK7 gene overexpression was significantly associated with tumor progression, poor treatment response, and worse overall survival, suggesting that MAPK7 could play an important role in OS tumorigenesis. We have investigated if MAPK7 overexpression was a result of any genomic changes in OS tumor specimens. We identified five SNPs (Single Nucleotide...
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#1Bruna Mascaro-Cordeiro (UNIFESP: Federal University of São Paulo)H-Index: 1
#2Indhira Dias Oliveira (UNIFESP: Federal University of São Paulo)H-Index: 9
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 21
view all 8 authors...
Purpose Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB). In the present study, we investigated VA role, combined to cisplatin (CDDP) in cell viability and gene expression of MB cell lines.
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// Alini Trujillo-Paolillo 1, 2 , Francine Tesser-Gamba 1 , Antonio Sergio Petrilli 3 , Maria Teresa de Seixas Alves 4 , Reynaldo Jesus Garcia Filho 5 , Renato de Oliveira 6 and Silvia Regina Caminada de Toledo 1, 2, 7 1 Genetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Federal University of Sao Paulo, Rua Botucatu, Vila Clementino, Sao Paulo SP, 04023-062, Brazil 2 Department of Clinical and Experimental Oncology, Federal University of Sao Paulo, Rua Dr. Diogo de Faria, Vila Cleme...
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#1Luana Joyce Silva Lopes (UNIFESP: Federal University of São Paulo)H-Index: 2
#2Francine Tesser-Gamba (UNIFESP: Federal University of São Paulo)H-Index: 4
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 21
view all 6 authors...
Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The search for biomarkers or new therapeutic targets is urgently needed and can help in advances of OS treatment. MAPKs are major signaling transduction molecules that play an important role in regulating a variety of cellular responses. DUSP1 is a phosphatase that dephosphorylates...
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#1Francine Tesser-Gamba (UNIFESP: Federal University of São Paulo)H-Index: 4
#2Luana Joyce Silva Lopes (UNIFESP: Federal University of São Paulo)H-Index: 2
Last. Silvia Regina Caminada de Toledo (UNIFESP: Federal University of São Paulo)H-Index: 21
view all 4 authors...
Osteosarcomas (OS) are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well as to develop novel therapeutic strategies. In our previous study, MAPK7 has been identified as a candidate oncogene, and a promising prognostic marker for OS. Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK) cascades is a common mechan...
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