Phyllis I. Spuls
University of Amsterdam
Quality of lifeInternal medicineSurgeryOutcome (game theory)DermatologyRandomized controlled trialIntensive care medicinePediatricsEvidence-based medicineAdverse effectImmunologyAlternative medicineAtopic dermatitisDiseaseMEDLINEAdalimumabPsoriasisEczema Area and Severity IndexMethotrexateSeverity of illnessFamily medicineClinical trialMedicine
Publications 112
#1Merel L.E. Stor (UvA: University of Amsterdam)
#2M.M. Lokhorst (UvA: University of Amsterdam)H-Index: 4
Last. Chantal M.A.M. van der Horst (UvA: University of Amsterdam)H-Index: 27
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OBJECTIVE Vascular malformations (VM) can negatively impact the patient's quality of life (QoL). Pain is a common problem in these patients. The aim of this study was to investigate risk factors associated with pain and to assess how pain affects QoL. METHODS This prospective cross-sectional study was conducted in a tertiary vascular anomaly expertise center. Between June and December 2020, all patients from our local database (334 adults and 189 children) with peripheral VMs were invited to com...
#1Astrid M. van Huizen (UvA: University of Amsterdam)
#2F.M. Vermeulen (UvA: University of Amsterdam)H-Index: 3
Last. Phyllis I. Spuls (UvA: University of Amsterdam)H-Index: 28
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If an authorized drug is prescribed for a use that is not described in the Summary of Product Characteristics, this is defined as 'off-label use.' Methotrexate is often used off-label for dermatological indications. Off-label use is permitted if physicians can justify the treatment based on scientific evidence available to them. Our objective here was therefore to summarize the evidence for the effectiveness, efficacy, and safety of the dermatological off-label use of methotrexate in a systemati...
Patient-reported outcomes (PROs) on adverse drug reactions (ADRs) are increasingly used in cohort event monitoring (CEM) to obtain a better understanding of patients’ real-world experience with dru...
Background: null Information on adverse drug reactions (ADRs) is generally clustered for all indications of a drug in the patient information leaflet. However, previous research has shown that participants of the Dutch Biologic Monitor (DBM) that use a biologic for their immune-mediated inflammatory disease (IMID) prefer to receive ADR information tailored to their own biologic an IMID (1). Currently, it is unclear whether the ADR profile of a specific biologic may differ between patients with d...
#1Rowdy de Groot (UvA: University of Amsterdam)
#2A.L. Bosma (UvA: University of Amsterdam)H-Index: 5
Last. Phyllis I. Spuls (UvA: University of Amsterdam)H-Index: 28
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#1Esther E. Freeman (Harvard University)H-Index: 20
#2Grace C. Chamberlin (Harvard University)
Last. Michelle A. Lowes (Rockefeller University)H-Index: 48
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Background Indirect excess morbidity has emerged as a major concern in the COVID-19 pandemic. People with psoriasis may be particularly vulnerable to this because of prevalent anxiety and depression, multimorbidity and therapeutic use of immunosuppression. Objective Characterise the factors associated with worsening psoriasis in the COVID-19 pandemic, using mental health status (anxiety and depression) as the main exposure of interest. Methods Global cross-sectional study using a primary outcome...
BACKGROUND Surgical treatment of peripheral vascular malformations is widely performed as primary and secondary treatments. Excellent results have been reported; however, it is thought that complications are likely to occur because of damage to adjacent structures. This systematic review aimed to elucidate the indications and outcomes of surgical treatment of vascular malformations. METHODS PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for studies reporting...
3 CitationsSource
#1Dmitri Wall (BlackRock)H-Index: 8
#2Raed Alhusayen (Sunnybrook Research Institute)H-Index: 13
Last. Alan D. Irvine (UCD: University College Dublin)H-Index: 73
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Abstract High-quality dermatology patient registries often require considerable time to develop and produce meaningful data. Development time is influenced by registry complexity and regulatory hurdles that vary significantly nationally and institutionally. The rapid emergence of the COVID-19 global pandemic has challenged health services in an unprecedented manner. Mobilization of the dermatology community in response has included rapid development and deployment of multiple, partially harmoniz...
2 CitationsSource