Christine H. Feng
University of California, San Diego
CancerInternal medicineOncologyHippocampal formationDiffusion MRIStage (cooking)Radiation treatment planningProstateHead and neck cancerCervical cancerContouringComorbidityWhole brain radiotherapyProstate cancerNuclear medicineClinical risk factorPlanning target volumeConfidence intervalRadiation therapyReceiver operating characteristicMedicine
26Publications
5H-index
85Citations
Publications 24
Newest
#1Zhong Ay (UCSD: University of California, San Diego)
#2Leonardino A. Digma (UCSD: University of California, San Diego)H-Index: 2
Last. Tyler M. SeibertH-Index: 18
view all 16 authors...
PurposeMultiparametric MRI (mpMRI) improves detection of clinically significant prostate cancer (csPCa), but the qualitative PI-RADS system and quantitative apparent diffusion coefficient (ADC) yield inconsistent results. An advanced Restrictrion Spectrum Imaging (RSI) model may yield a better quantitative marker for csPCa, the RSI restriction score (RSIrs). We evaluated RSIrs for patient-level detection of csPCa. Materials and MethodsRetrospective analysis of men who underwent mpMRI with RSI an...
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#1Christine H. Feng (UCSD: University of California, San Diego)H-Index: 5
#2Christopher C. Conlin (UCSD: University of California, San Diego)H-Index: 3
Last. Tyler M. Seibert (UCSD: University of California, San Diego)H-Index: 18
view all 11 authors...
BACKGROUND Diffusion magnetic resonance imaging (MRI) is integral to detection of prostate cancer (PCa), but conventional apparent diffusion coefficient (ADC) cannot capture the complexity of prostate tissues and tends to yield noisy images that do not distinctly highlight cancer. A four-compartment restriction spectrum imaging (RSI4 ) model was recently found to optimally characterize pelvic diffusion signals, and the model coefficient for the slowest diffusion compartment, RSI4 -C1 , yielded g...
1 CitationsSource
#1Christine H. Feng (UCSD: University of California, San Diego)H-Index: 5
#2Steve Braunstein (UCSF: University of California, San Francisco)H-Index: 26
Last. Iain MacEwan (UCSD: University of California, San Diego)H-Index: 7
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#1Brandon A. Dyer (University of Washington Medical Center)H-Index: 3
#1Brandon A. Dyer (University of Washington Medical Center)H-Index: 1
Last. Jyoti Mayadev (UCSD: University of California, San Diego)H-Index: 15
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Novel therapies combined with radiation continue to be of significant interest in the developmental treatment paradigm of gynecologic cancers. Clinical implementation of immunotherapy in oncology has rapidly changed the treatment landscape, options, paradigm, and outcomes through clinical trials. Immunotherapy has emerged as a therapeutic pillar in the treatment of solid tumors with demonstrable synergistic activity when combined with radiotherapy and chemoradiotherapy by an alteration or enhanc...
1 CitationsSource
#1Christopher C. Conlin (UCSD: University of California, San Diego)H-Index: 3
#2Christine H. Feng (UCSD: University of California, San Diego)H-Index: 5
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
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BACKGROUND Multicompartmental modeling outperforms conventional diffusion-weighted imaging (DWI) in the assessment of prostate cancer. Optimized multicompartmental models could further improve the detection and characterization of prostate cancer. PURPOSE To optimize multicompartmental signal models and apply them to study diffusion in normal and cancerous prostate tissue in vivo. STUDY TYPE Retrospective. SUBJECTS Forty-six patients who underwent MRI examination for suspected prostate cancer; 2...
1 CitationsSource
#1Leonardino A. Digma (UCSD: University of California, San Diego)H-Index: 2
#2Christine H. Feng (UCSD: University of California, San Diego)H-Index: 5
Last. Tyler M. Seibert (UCSD: University of California, San Diego)H-Index: 18
view all 12 authors...
BackgroundAccurate imaging of bone metastases is necessary for treatment planning and assessing treatment response. Diffusion-weighted magnetic resonance imaging (DWI) can detect bone metastases, but DWI acquired with echo-planar imaging is susceptible to distortions due to static magnetic field inhomogeneities. PurposeEstimate spatial displacements of bone lesions on DWI. Examine whether distortion-corrected DWI more accurately reflects underlying anatomy. Study TypeRetrospective. Subjects18 pa...
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Abstract Purpose Design and evaluate a workflow using commercially available artificial intelligence tools for automated hippocampal segmentation and treatment planning to efficiently generate clinically acceptable hippocampal-avoidant whole brain (HA-WBRT) radiotherapy plans. Methods and Materials We retrospectively identified 100 consecutive adult patients treated for brain metastases outside the hippocampal region. Each patient’s T1 post-contrast brain MRI was processed using FDA-approved sof...
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#1Christine H. Feng (Translational Research Institute)H-Index: 5
#2M. Cornell (Translational Research Institute)H-Index: 5
Last. Tyler M. Seibert (UCSD: University of California, San Diego)H-Index: 18
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Whole-brain radiotherapy (WBRT) remains an important treatment for over 200,000 cancer patients in the United States annually. Hippocampal-avoidant WBRT (HA-WBRT) reduces neurocognitive toxicity compared to standard WBRT, but HA-WBRT contouring and planning are more complex and time-consuming than standard WBRT. We designed and evaluated a workflow using commercially available artificial intelligence tools for automated hippocampal segmentation and treatment planning to efficiently generate clin...
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#1Christine H. Feng (UCSD: University of California, San Diego)H-Index: 5
#2Loren K. Mell (UCSD: University of California, San Diego)H-Index: 52
Last. Jyoti Mayadev (UCSD: University of California, San Diego)H-Index: 15
view all 5 authors...
Outcomes for women with node-positive, recurrent, and metastatic cervical cancer remain poor. Persistent infection by the human papilloma virus is related to disordered interactions with the immune system and development of cervical cancer, making the resultant malignancy an attractive target for immunotherapy. Various types of immunomodulatory treatments have been studied, including a bacterial vaccine vector and T cell therapy. Immune checkpoint blockade has shown promise in the recurrent or m...
1 CitationsSource
#1Christine H. Feng (UCSD: University of California, San Diego)H-Index: 5
#2Christopher C. Conlin (UCSD: University of California, San Diego)H-Index: 3
Last. Tyler M. Seibert (UCSD: University of California, San Diego)H-Index: 18
view all 11 authors...
Purpose: Diffusion MRI is integral to detection of prostate cancer (PCa), but conventional ADC cannot capture the complexity of prostate tissues. A four-compartment restriction spectrum imaging (RSI4) model was recently found to optimally characterize pelvic diffusion signals, and the model coefficient for the slowest diffusion compartment, RSI4-C1, yielded greatest tumor conspicuity. In this study, RSI4-C1 was evaluated as a quantitative voxel-level classifier of PCa. Methods: This was a retros...
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