Christopher B. Buck
National Institutes of Health
GeneNeutralizationGenomeAntigenMolecular biologyVirologyAntibodyEpitopeCapsidImmunologyPlasmidVirusMerkel cell polyomavirusMerkel cell carcinomaPolyomavirus InfectionsTropismSerologyDNAComputational biologyMedicineBiologyImmune system
122Publications
52H-index
10.1kCitations
Publications 119
Newest
#1Michael J. Tisza (NIH: National Institutes of Health)H-Index: 7
#2Christopher B. Buck (NIH: National Institutes of Health)H-Index: 52
Despite remarkable strides in microbiome research, the viral component of the microbiome has generally presented a more challenging target than the bacteriome. This gap persists, even though many thousands of shotgun sequencing runs from human metagenomic samples exist in public databases, and all of them encompass large amounts of viral sequence data. The lack of a comprehensive database for human-associated viruses has historically stymied efforts to interrogate the impact of the virome on hum...
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#1Rong Yang (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
#2Eunice E. Lee (UTSW: University of Texas Southwestern Medical Center)H-Index: 6
Last. Richard C. Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 25
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Circular RNAs (circRNAs) are a conserved class of RNAs with diverse functions, including serving as messenger RNAs that are translated into peptides. Here we describe circular RNAs generated by human polyomaviruses (HPyVs), some of which encode variants of the previously described alternative large T antigen open reading frame (ALTO) protein. Circular ALTO RNAs (circALTOs) can be detected in virus positive Merkel cell carcinoma (VP-MCC) cell lines and tumor samples. CircALTOs are stable, predomi...
1 CitationsSource
#1Kara Schmidlin (ASU: Arizona State University)H-Index: 7
#2Simona Simona Kraberger (ASU: Arizona State University)H-Index: 1
Last. Arvind VarsaniH-Index: 63
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Polyomaviruses are nonenveloped viruses with circular double stranded DNA genomes that range in size from ~4 to 7 kilobasepairs. Initially identified in mammals, polyomaviruses have now been identified in birds and a few fish species. Although fragmentary polyomavirus-like sequences have been detected as apparent 9hitchhikers9 in shotgun genomics datasets for various arthropods, the possible diversity of these viruses in invertebrates remains unclear. In general, polyomaviruses are host-specific...
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3 CitationsSource
#1Samuel S. Porter (UMD: University of Maryland, College Park)H-Index: 1
#1Samuel S. Porter (NIH: National Institutes of Health)H-Index: 2
Last. Alison A. McBride (NIH: National Institutes of Health)H-Index: 50
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ABSTRACT An unusual feature of papillomaviruses is that their genomes are packaged into virions along with host histones. Viral minichromosomes were visualized as “beads on a string” by electron microscopy in the 1970s but, to date, little is known about the posttranslational modifications of these histones. To investigate this, we analyzed the histone modifications in HPV16/18 quasivirions, wart-derived bovine papillomavirus (BPV1), and wart-derived human papillomavirus type 1 (HPV1) using quan...
2 CitationsSource
#1Michael J. TiszaH-Index: 7
#2Anna K. BelfordH-Index: 4
Last. Christopher B. BuckH-Index: 52
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Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as 'hypothetical protein' or the equivalent. Cenote-Taker 2, a virus discovery and annotation tool available on command line and with a graphical user interface wit...
2 CitationsSource
#1Michael J. TiszaH-Index: 7
Last. Buck Cb
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Abstract While there have been remarkable strides in microbiome research, the viral component of the microbiome has generally presented a more challenging target than the bacteriome. This is despite the fact that many thousands of shotgun sequencing runs from human metagenomic samples exist in public databases and all of them encompass large amounts of viral sequences. The lack of a comprehensive database for human-associated viruses, along with inadequate methods for high-throughput identificat...
2 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Michael J. TiszaH-Index: 7
Last. Christopher B. BuckH-Index: 52
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4 CitationsSource
#1Michael J. TiszaH-Index: 7
#2Anna K. BelfordH-Index: 4
Last. Christopher B. BuckH-Index: 52
view all 6 authors...
Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as hypothetical protein or the equivalent. Cenote-Taker2, a virus discovery and annotation tool available on command line and with a graphical user interface with f...
1 CitationsSource
#1Gabriel J. StarrettH-Index: 21
#2Kelly J. YuH-Index: 18
Last. Christopher B. BuckH-Index: 52
view all 8 authors...
BK polyomavirus (BKPyV) is a ubiquitous virus that establishes a lifelong subclinical infection in the urinary tract. In transplant recipients, BKPyV can reactivate and cause kidney and bladder damage. Recent sequencing studies of tumors from transplant recipients have revealed that BKPyV sequences are present in approximately 25% of bladder tumors. This is dramatically higher than the Citation Format: Gabriel J. Starrett, Kelly Yu, David Petersen, Petra Lenz, Lars Dyrskjot, Paul Meltzer, Eric E...
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