Simona Granata
University of Verona
Internal medicinePeripheral blood mononuclear cellPathologyVimentinTranscriptomePharmacogenomicsIntensive care medicineImmunologyInflammationHeparanaseSirolimusHemodialysisKidney diseaseEverolimusDialysisKidneyImmunosuppressionFibrosisMitochondrionTransplantationCancer researchNephrologyBioinformaticsMedicineEpithelial–mesenchymal transitionPI3K/AKT/mTOR pathwayBiologyPharmacology
61Publications
17H-index
890Citations
Publications 61
Newest
#1Simona GranataH-Index: 17
#2Pierluigi CarratùH-Index: 21
Last. Gianluigi ZazaH-Index: 30
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Kidney transplant recipients are at high risk of developing severe COVID-19 due to the coexistence of several transplant-related comorbidities (e.g., cardiovascular disease, diabetes) and chronic immunosuppression. As a consequence, a large part of SARS-CoV-2 infected patients have been managed with a reduction of immunosuppression. The mTOR-I, together with antimetabolites, have been often discontinued in order to minimize the risk of pulmonary toxicity and to antagonize pharmacological interac...
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#1Marianna LucafòH-Index: 13
#2Simona GranataH-Index: 17
Last. Gianluigi ZazaH-Index: 30
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To assess whether NLRP3 gene promoter methylation was able to discriminate glucocorticoid-resistant from glucocorticoid-sensitive idiopathic nephrotic syndrome (INS) patients with minimal change disease (MCD) or focal glomerulosclerosis (FSGS), we measured the methylation level of NLRP3 promoter in DNA from peripheral blood cells of 10 adult glucocorticoid-resistant FSGS patients already in hemodialysis and 18 glucocorticoid-sensitive INS patients (13 MCD/5 FSGS) and in 21 INS pediatric patients...
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#1Simona GranataH-Index: 17
#2Maurizio Bruschi (Istituto Giannina Gaslini)H-Index: 30
Last. Gianluigi ZazaH-Index: 30
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Background: Molecular biology has recently added new insights into the comprehension of the physiopathology of the medullary sponge kidney disease (MSK), a rare kidney malformation featuring nephrocalcinosis and recurrent renal stones. Pathogenesis and metabolic alterations associated to this disorder have been only partially elucidated. Methods: Plasma and urine samples were collected from 15 MSK patients and 15 controls affected by idiopathic calcium nephrolithiasis (ICN). Plasma metabolomic p...
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#1Isabella Panfoli (UniGe: University of Genoa)H-Index: 29
#2Simona GranataH-Index: 17
Last. Gianluigi ZazaH-Index: 30
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Introduction: Exosomes are nanovesicles that play important functions in a variety of physiological and pathological conditions. They are powerful cell-to-cell communication tool thanks to the protein, mRNA, miRNA, and lipid cargoes they carry. They are also emerging as valuable diagnostic and prognostic biomarker sources. Urinary exosomes carry information from all the cells of the urinary tract, downstream of the podocyte. Rare kidney diseases are a subset of an inherited diseases whose geneti...
1 CitationsSource
#1Simona GranataH-Index: 17
#2Gloria SantoroH-Index: 2
Last. Gianluigi ZazaH-Index: 30
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#1Claudia CantoniH-Index: 56
#2Simona GranataH-Index: 17
Last. Gianluigi ZazaH-Index: 30
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Growing evidences are revealing a central role for Natural Killer (NK) cells, cytotoxic cells belonging to the emerging family of Innate Lymphoid Cells (ILCs), in acute and chronic forms of renal disease. NK cell effector functions include both the recognition and elimination of virus infected and tumor cells and the capability of sensing pathogens through Toll-like receptor (TLR) engagement. Notably, they also display immune regulatory properties, exerted thanks to their ability to secrete cyto...
1 CitationsSource
#1Gloria Santoro (University of Verona)H-Index: 2
#2Simona Granata (University of Verona)H-Index: 17
Last. Gianluigi Zaza (University of Verona)H-Index: 30
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#1Simona Granata (University of Verona)H-Index: 17
#2Gabriele Stocco (UniTS: University of Trieste)H-Index: 21
Last. Gianluigi Zaza (University of Verona)H-Index: 30
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#1Jingyuan Xie (SJTU: Shanghai Jiao Tong University)H-Index: 16
#2Lili Liu (Columbia University)H-Index: 9
Last. Krzysztof Kiryluk (Columbia University)H-Index: 37
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Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 controls of East Asian and European ancestries. We discover two previously unreported loci, NFKB1 (rs230540, OR = 1.25, P = 3.4 × 10−12) and IRF4 (rs9405192, OR = 1.29, P = 1.4 × 10−14), fine-map the PLA2R1 locus (rs17831251, OR = 2.25, P = 4.7 × 10−103) and report ancestry-specific effects of three classical HLA alleles: DRB1*...
31 CitationsSource