Kimiko Inoue
University of Tsukuba
GeneOffspringSpermatogenesisSomatic cellPathologyEmbryonic stem cellCellular differentiationMolecular biologyAndrologyEmbryoGenomic imprintingSomatic cell nuclear transferCloningImmunologyMitochondrial DNAGerm cellSpermStem cellTransplantationGeneticsMedicineReprogrammingBiologyCell biology
Publications 129
A Japanese woman first noticed dysarthria at the age of 23. She visited a hospital at the age of 32 and was diagnosed as having myotonic dystrophy clinically. She was diagnosed genetically as having myotonic dystrophy type 1 at 47 years old with 160-270 CTG repeats on the DMPK gene. At the age of 48, she needed non-invasive positive pressure ventilation because of hypoxia at night. Her gait function also deteriorated. She could not stand up from the supine position by herself. However, when she ...
#1Satoshi KamimuraH-Index: 13
#2Kimiko Inoue (University of Tsukuba)H-Index: 53
Last. Atsuo Ogura (University of Tsukuba)H-Index: 75
view all 15 authors...
In mammalian cloning by somatic cell nuclear transfer (SCNT), treatment of reconstructed embryos with histone deacetylase (HDAC) inhibitors improves efficiency. So far, most of those used for SCNT are hydroxamic acid derivatives-such as trichostatin A-characterized by their broad inhibitory spectrum. Here, we examined whether mouse SCNT efficiency could be improved using chlamydocin analogues, a family of newly designed agents that specifically inhibit Class I and IIa HDACs. Development of SCNT-...
#1Yuki Kobayashi (YCU: Yokohama City University)H-Index: 1
#2Shin-ichi Tomizawa (YCU: Yokohama City University)H-Index: 10
Last. Kazuyuki Ohbo (YCU: Yokohama City University)H-Index: 14
view all 19 authors...
During spermatogenesis, intricate gene expression is coordinately regulated by epigenetic modifiers, which are required for differentiation of spermatogonial stem cells (SSCs) contained among undifferentiated spermatogonia. We previously found that KMT2B conveys H3K4me3 at bivalent and monovalent promoters in undifferentiated spermatogonia. Because these genes are expressed late in spermatogenesis or during embryogenesis, we expect that many of them are potentially programmed by KMT2B for future...
#1Atsuo OguraH-Index: 75
#2Shogo MatobaH-Index: 26
Last. Kimiko InoueH-Index: 53
view all 3 authors...
Twenty-five years have passed since the birth of Dolly the sheep, the first mammalian clone produced by adult somatic cell nuclear transfer (SCNT). During that time, the main thrust of SCNT-related research has been the elucidation of SCNT-associated epigenetic abnormalities and their correction, with the aim of improving the efficiency of cloned animal production. Through these studies, it has become clear that some epigenomic information can be reprogrammed by the oocyte, while some cannot. No...
#1Ayumi HasegawaH-Index: 12
#2Keiji MochidaH-Index: 23
Last. Atsuo OguraH-Index: 75
view all 9 authors...
The genus Mus consists of many species with high genetic diversity. However, only one species, Mus musculus (the laboratory mouse), is common in biomedical research. The unavailability of assisted reproductive technologies (ARTs) for other Mus species might be a major reason for their limited use in laboratories. Here, we devised ARTs for Mus spretus (the Algerian mouse), a commonly used wild-derived Mus species. We found that in vitro production of M. spretus embryos was difficult because of lo...
#1Takashi Ishiuchi (Kyushu University)H-Index: 10
#2Shusaku Abe (Kyushu University)H-Index: 2
Last. Hiroyuki Sasaki (Kyushu University)H-Index: 81
view all 7 authors...
Epigenetic reprogramming of the zygote involves dynamic incorporation of histone variant H3.3. However, the genome-wide distribution and dynamics of H3.3 during early development remain unknown. Here, we delineate the H3.3 landscapes in mouse oocytes and early embryos. We unexpectedly identify a non-canonical H3.3 pattern in mature oocytes and zygotes, in which local enrichment of H3.3 at active chromatin is suppressed and H3.3 is relatively evenly distributed across the genome. Interestingly, a...
2 CitationsSource
An 89-year-old man was admitted because of persistent fever and impaired consciousness. On admission, his consciousness level was E3V3M4 according to the Glasgow Coma Scale. MRI of the brain showed high intensity lesions in the bilateral cingulate gyri. In the cerebrospinal fluid, both cell counts and glucose level were in the normal ranges. He had received antibiotics and intravenous isotonic saline. On the fifth day of hospitalization, blood examination revealed elevation of anti-herpes simple...
#1Kento Miura (Hiroshima University)H-Index: 6
#2Kimiko InoueH-Index: 53
Last. Osamu Kaminuma (Hiroshima University)H-Index: 23
view all 4 authors...
The essential contribution of CD4+ T cells in allergic airway diseases has been demonstrated, especially by using various murine models of antigen-induced airway inflammation. In addition to antigen-immunized mouse models employing mast cell-deficient mice and CD4+ T cell-depleting procedure, antigen-specific CD4+ T cell transfer models have revealed the possible development of allergic inflammation solely dependent on CD4+ T cells. Regardless of the classical Th1/Th2 theory, various helper T ce...
2 CitationsSource
#1Yasuhiro Kazuki (Tottori University)H-Index: 31
#2Feng J. Gao (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
Last. Roger H. Reeves (Johns Hopkins University)H-Index: 6
view all 34 authors...
Animal models of Down syndrome (DS), trisomic for human chromosome 21 (HSA21) genes or orthologs, provide insights into better understanding and treatment options. The only existing transchromosomic (Tc) mouse DS model, Tc1, carries a HSA21 with over 50 protein coding genes (PCGs) disrupted. Tc1 is mosaic, compromising interpretation of results. Here, we 'clone' the 34 MB long arm of HSA21 (HSA21q) as a mouse artificial chromosome (MAC). Through multiple steps of microcell-mediated chromosome tr...
10 CitationsSource
#1Yasuhiro Kazuki (Tottori University)H-Index: 31
#2Feng J. Gao (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
Last. Roger H. Reeves (Johns Hopkins University)H-Index: 62
view all 34 authors...
1 CitationsSource