Thomas H. Mosley
University of Mississippi
Genome-wide association studyInternal medicineEndocrinologyCardiologyCognitionNeurocognitiveProspective cohort studyCohort studyAtherosclerosis Risk in CommunitiesDiseaseDementiaPopulationCognitive declineAric studyRisk factorStrokeGeneticsMedicineCohortGerontologyBlood pressureBiology
Publications 726
#1Emily M. Briceño (UM: University of Michigan)H-Index: 14
#2Alden L. Gross (Johns Hopkins University)H-Index: 35
Last. Clinton B. Wright (NIH: National Institutes of Health)H-Index: 59
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#1Caitlin W. Hicks (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 28
#2Ada Al-Qunaibet (UNC: University of North Carolina at Chapel Hill)H-Index: 1
Last. Gerardo Heiss (UNC: University of North Carolina at Chapel Hill)H-Index: 141
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Abstract null null Background and aims null Symptomatic peripheral artery disease (PAD) is a risk factor for abdominal aortic aneurysm (AAA). However, data on the association of asymptomatic PAD with AAA are limited. We explored the association of symptomatic and asymptomatic PAD with AAA. null null null Methods null We primarily assessed a prospective association of symptomatic (based on clinical history) and asymptomatic (ankle-brachial index ≤0.9) PAD at baseline (1987–89 [ages 45–64 years]) ...
#1Kevin J. Sullivan (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Chad Blackshear (UMMC: University of Mississippi Medical Center)H-Index: 11
Last. David S. Knopman (Mayo Clinic)H-Index: 145
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Objective. null To evaluate the association between midlife plasma amyloid-beta (Aβ1-42, Aβ1-40, Aβ42:Aβ40) and risk of MCI and dementia. null Methods. null Plasma Aβ42 and Aβ40 were retrospectively measured using a fluorimetric bead-based immunoassay in a subsample of the Atherosclerosis Risk in Communities cohort study. We investigated the relationship of plasma Aβ42, Aβ40, and Aβ42:Aβ40 ratio measured in midlife, late-life, and the change from midlife to late-life, to risk of MCI, dementia, a...
#1Farah Ammous (UM: University of Michigan)H-Index: 2
#2Wei Zhao (UM: University of Michigan)H-Index: 77
Last. Jennifer A. Smith (UM: University of Michigan)H-Index: 70
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Target organ damage (TOD) manifests as vascular injuries in the body organ systems associated with long-standing hypertension. DNA methylation in peripheral blood leukocytes can capture inflammator...
3 CitationsSource
#1Wendy WangH-Index: 1
#2Michael J. ZhangH-Index: 2
Last. Thomas H. MosleyH-Index: 95
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#1Nicholette D. Palmer (Wake Forest University)H-Index: 43
#2Bratati Kahali (UM: University of Michigan)H-Index: 15
Last. Elizabeth K. Speliotes (UM: University of Michigan)H-Index: 48
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Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the largest multiethnic investigation of exonic variation associated with NAFLD and correlated metabolic traits and diseases. An exome array meta-analysis was carried out among eight multiethnic population-based cohorts (n = 16 492) with computed tomograp...
2 CitationsSource
#2Keenan A. WalkerH-Index: 12
Last. Anna E. PrizmentH-Index: 25
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#1He S (Harvard University)
#2Einat G (Harvard University)
Last. Melissa Lamar (UIC: University of Illinois at Chicago)H-Index: 30
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INTRODUCTION: Blood metabolomics-based biomarkers may be useful to predict measures of neurocognitive aging. METHODS: We tested the association between 707 blood metabolites measured in 1,451 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), with MCI and global cognitive change assessed seven years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolite...
#1Alison G. Abraham (University of Colorado Denver)H-Index: 31
#2Xinxing Guo (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 14
Last. Alexander Tomlinson (OHSU: Oregon Health & Science University)H-Index: 2
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#8Christie M. Ballantyne (BCM: Baylor College of Medicine)H-Index: 137
#8Christie M. Ballantyne (BCM: Baylor College of Medicine)H-Index: 27
ARIC (Atherosclerosis Risk In Communities) initiated community-based surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence and mortality and created a prospective cohort of 15,792 Black and White adults ages 45 to 64 years. The primary aims were to improve understanding of the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in Black and White middle-age adults. ARIC has examined areas including health disparities, geno...