David Proud
Johns Hopkins University
Provocation testHistamineInternal medicineEndocrinologyAntigenMolecular biologyChemistryImmunologyAllergyKininNasal provocation testInflammationBradykininMast cellAllergenNasal LavageMucous membrane of noseMedicineBiologyPharmacology
186Publications
18H-index
10.2kCitations
Publications 41
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#1Robert M. NaclerioH-Index: 91
#2Walter C. HubbardH-Index: 43
Last. David ProudH-Index: 18
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#1Robert M. NaclerioH-Index: 91
#2David ProudH-Index: 18
Last. Alkis TogiasH-Index: 88
view all 6 authors...
Ten subjects with a history of cold air-induced nasal symptoms participated in a randomized two-period crossover study to evaluate the occurrence and magnitude of the reaction induced by inhalation and exhalation of cold dry air through the nose. The protocol involved breathing of either warm moist or cold dry air for 45 min at resting breathing rates. The nasal response was quantified by determining the amount of produced secretions as well as by measuring histamine and N-alpha-p-tosyl-L-argini...
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#1A. J. Coyle (University of Colorado Hospital)H-Index: 2
#2Steven J. AckermanH-Index: 1
Last. C.G. IrvinH-Index: 3
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Abstract In the current series of experiments we investigated the role of bradykinin in airway hyperresponsiveness induced by human eosinophil-granule major basic protein (MBP). Bronchoalveolar lavage was performed after intratracheal instillation of MBP or poly-L-lysine in anesthetized, intubated rats, and levels of immunoreactive kinins and kallikrein-like activity were determined. Both MBP and poly-L-lysine induced a three- and eightfold increase in levels of kallikrein-like activity and i-ki...
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Differential nasal responsiveness to environmental tobacco smoke (ETS) has been documented in humans and we hypothesized that this reflects differential responsiveness to c-fiber stimulation. We compared the response to intranasal capsaicin in subjects with and without a history of ETS-rhinitis. We challenged 10 ETS-sensitive and 11 ETS-nonsensitive subjects intranasally with 25 mg of lactose powder followed by 25 pg to 25 ng of capsaicin in 25 mg of lactose. Subjects rated nasal symptoms and un...
#1Rebecca BascomH-Index: 33
#2Thomas J. KulleH-Index: 12
Last. David Proud (UMB: University of Maryland, Baltimore)H-Index: 18
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Some patients report rhinitis symptoms after exposure to environmental tobacco smoke (ETS), but objective assessments of this response have been lacking. Furthermore, the mechanism of this response is unknown. We assessed the frequency of ETS-related symptoms by administering a questionnaire to 77 healthy nonsmoking young adults who were participating in an unrelated study. Of the subjects 34% (26 of 77) reported one or more rhinitis symptoms (congestion, rhinorrhea, or sneezing) following ETS e...
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