Tomohiro Terasaka
University of California, San Diego
Internal medicineEndocrinologySurgeryPathologyReceptorGene knockdownChemistryGonadotropic cellStimulationAndrogenMelatoninLuteinizing hormoneGonadotropinGonadotropin-releasing hormoneAnterior pituitaryBone morphogenetic proteinSecretionMAPK/ERK pathwayHormoneMedicineBiologyGastroenterologyCell biology
37Publications
10H-index
248Citations
Publications 37
Newest
#1Hideharu Hagiya (Okayama University)H-Index: 13
#2Hiroko Ogawa (Okayama University)H-Index: 19
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 11 authors...
: We describe a rare case of recurrent Stenotrophomonas maltophilia bacteremia in a previously healthy 45-year-old man. The infection was caused by osteomyelitis at the site of an iliac crest bone graft harvest. A genetic analysis using enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) revealed that the blood isolates and pathogens obtained from the surgical wound were identical. Initial treatment with levofloxacin and cefozopran was ineffective, but the patien...
Source
#1Hideharu Hagiya (Okayama University)H-Index: 13
#2Tomohiro Terasaka (Okayama University)H-Index: 10
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 8 authors...
We herein report a case of persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that was successfully treated with combination therapy consisting of high-dose daptomycin (DAP, 10 mg/kg) and rifampicin. The patient's condition was complicated with multiple infectious foci, including an iliopsoas abscess and epidural abscess, as well as discitis and spondylitis at the cervical, thoracic and lumbar levels. Monotherapy treatments with vancomycin, linezolid and usual-dose DAP were...
5 CitationsSource
#1Tomohiro Terasaka (Okayama University)H-Index: 10
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 10 authors...
Reproduction is integrated by interaction of neural and hormonal signals converging on hypothalamic neurons for controlling gonadotropin-releasing hormone (GnRH). Kisspeptin, the peptide product of the kiss1 gene and the endogenous agonist for the GRP54 receptor, plays a key role in the regulation of GnRH secretion. In the present study, we investigated the interaction between kisspeptin, estrogen and BMPs in the regulation of GnRH production by using mouse hypothalamic GT1-7 cells. Treatment wi...
29 CitationsSource
#1Naoko Tsukamoto (Okayama University)H-Index: 13
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 9 authors...
Abstract The role of melatonin, a regulator of circadian rhythm, in adrenocorticotropin (ACTH) production by corticotrope cells has not been elucidated. In this study, we investigated the effect of melatonin on ACTH production in relation to the biological activity of bone morphogenetic protein (BMP)-4 using mouse corticotrope AtT20 cells that express melatonin type-1 (MT1R) but not type-2 (MT2R) receptors. We previously reported that BMP-4 inhibits corticotropin-releasing hormone (CRH)-induced ...
24 CitationsSource
#1Naoko Tsukamoto (Okayama University)H-Index: 13
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 10 authors...
Abstract Mechanisms by which GHRP stimulates ACTH release in corticotrope cells were investigated using mouse corticotrope AtT20 cells by focusing on the biological activity of BMP-4. GHRP-2 increased ACTH and cAMP secretion by AtT20 cells; however, its effects were less potent than the effects of CRH. BMP-4 suppressed basal ACTH production and POMC transcription, and the inhibition of endogenous BMP receptor signaling led to an increase in ACTH production. Of note, BMP-4 suppressed ACTH product...
13 CitationsSource
#1Hiroyuki Otani (Okayama University)H-Index: 16
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 11 authors...
Recent studies have shown that bone morphogenetic proteins (BMPs) are important regulators in the pituitary–gonadal endocrine axis. We here investigated the effects of BMPs on GNRH production controlled by estrogen using murine GT1-7 hypothalamic neuron cells. GT1-7 cells expressed estrogen receptor a (ERa; ESR1 as listed in MGI Database), ERb (ESR2 as listed in MGI Database), BMP receptors, SMADs, and a binding protein follistatin. Treatment with BMP2 and BMP4 had no effect on Gnrh mRNA express...
16 CitationsSource
#1Jiro Suzuki (Okayama University)H-Index: 18
#2Fumio Otsuka (Okayama University)H-Index: 35
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 10 authors...
Primary Aldosteronism Caused by a Unilateral Adrenal Adenoma Accompanied by Autonomous Cortisol Secretion
9 CitationsSource