Michela Mori
University of Pavia
CytotoxicityBiomedical engineeringNanotechnologyChemistryMaterials scienceIn vitroSilver sulfadiazinePlatelet lysateBiocompatibilityMontmorilloniteHyaluronic acidChondroitin sulfateChitosanDrug deliveryMucoadhesionWound healingFibroblastChromatographyPlateletPharmacology
25Publications
17H-index
594Citations
Publications 25
Newest
#1Silvia Rossi (UNIPV: University of Pavia)H-Index: 52
#2Michela Mori (UNIPV: University of Pavia)H-Index: 17
Last. Franca Ferrari (UNIPV: University of Pavia)H-Index: 46
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Abstract The aim of the present work was to develop a medication allowing for the combined delivery of platelet lysate (PL) and an anti-infective model drug, vancomycin hydrochloride (VCM), to chronic skin ulcers. A simple method was set up for the preparation of hyaluronic acid (HA) core-shell particles, loaded with PL and coated with calcium alginate, embedded in a VCM containing alginate matrix. Two different CaCl2 concentrations were investigated to allow for HA/PL core-shell particle format...
16 CitationsSource
#1Bédis AmriH-Index: 3
#2Emanuela Martino (UNIPV: University of Pavia)H-Index: 10
Last. Simona Collina (UNIPV: University of Pavia)H-Index: 25
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Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic or non-healing wounds and thus, therapeutic strategies may represent the only beneficial alternative to ...
24 CitationsSource
#1Mária Budai-Szű cs (University of Szeged)H-Index: 1
#2Gabriella Horvát (University of Szeged)H-Index: 6
Last. Erzsébet Csányi (University of Szeged)H-Index: 20
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AbstractOcular drug delivery formulations must meet anatomical, biopharmaceutical, patient-driven and regulatory requirements. Mucoadhesive polymers can serve as a better alternative to currently available ophthalmic formulations by providing improved bioavailability. If all requirements are addressed, a polymeric formulation resembling the tear film of the eye might be the best solution. The optimum formulation must not have high osmotic activity, should provide appropriate surface tension, pH ...
6 CitationsSource
#1Michela Mori (UNIPV: University of Pavia)H-Index: 17
#2Silvia Rossi (UNIPV: University of Pavia)H-Index: 52
Last. Carla Caramella (UNIPV: University of Pavia)H-Index: 56
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The aim of the present work was the development of sponge-like dressings based on chitosan glutamate (high molecular weight) and sericin for the treatment of chronic skin ulcers. Dressings were prepared by freeze-drying and glycine was added as cryoprotectant agent. Dressing development was assisted by design of experiments, using a simplex centroid design. Mechanical resistance, hydration propensity, viscous, and viscoelasticity properties of dressings were considered as response variables. The...
28 CitationsSource
#1Michela Mori (UNIPV: University of Pavia)H-Index: 17
#2Silvia Rossi (UNIPV: University of Pavia)H-Index: 52
Last. Carla Caramella (UNIPV: University of Pavia)H-Index: 56
view all 10 authors...
Abstract Platelet lysate (PL) was loaded into dressings based on chitosan glutamate (CSG) low and high molecular weight, sericin (Ser), and glycine (Gly). A synergic effect of Ser and PL on fibroblast proliferation was proved in vitro . Two different PL loading approaches were considered: the first provided to prepare dressings by freeze-drying a mixture of PL and CSG/Gly/Ser solution, the second approach consisted in the extemporarily loading of PL in the CSG/Gly/Ser freeze-dried dressings. As ...
20 CitationsSource
#1Flavia Fontana (UH: University of Helsinki)H-Index: 17
#2Michela Mori (UNIPV: University of Pavia)H-Index: 17
Last. Hélder A. SantosH-Index: 149
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The new frontier in the treatment of chronic nonhealing wounds is the use of micro- and nanoparticles to deliver drugs or growth factors into the wound. Here, we used platelet lysate (PL), a hemoderivative of platelets, consisting of a multifactorial cocktail of growth factors, to modify porous silicon (PSi) microparticles and assessed both in vitro and ex vivo the properties of the developed microsystem. PL-modified PSi was assessed for its potential to induce proliferation of fibroblasts. The ...
23 CitationsSource
#1Gabriella Horvát (University of Szeged)H-Index: 6
#2Mária Budai-Szűcs (University of Szeged)H-Index: 12
Last. Erzsébet Csányi (University of Szeged)H-Index: 20
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Abstract Hyaluronic acid (HA) and its derivatives play important roles in many fields of therapy, such as arthritis treatment, plastic surgery, dermatology, otology, ophthalmology, etc. With a view to increase the beneficial properties of HA in ocular drug delivery, many types of chemical structural modifications have been performed. In the course of our research work, we characterized nanosized cross-linked – (CLNaHA), linear sodium hyaluronate (NaHA) and zinc-hyaluronate (ZnHA), as potential o...
16 CitationsSource
#1Giuseppina Sandri (UNIPV: University of Pavia)H-Index: 35
#2Maria Cristina Bonferoni (UNIPV: University of Pavia)H-Index: 53
Last. Carla Caramella (UNIPV: University of Pavia)H-Index: 56
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Introduction: The work presents the development of acellular scaffolds extemporaneously embedded with platelet lysate (PL), as an innovative approach in the field of tissue regeneration/reparation. PL embedded scaffolds should have a tridimensional architecture to support cell migration and growth, in order to restore skin integrity. For this reason, chondroitin sulfate (CS) was associated with sodium alginate (SA) to prepare highly porous systems.Methods: The developed scaffolds were characteri...
24 CitationsSource
Chitosan (CS) based nanocarriers have been extensively studied starting from early 90s. The unique properties of CS and in particular its capability to interact with various epithelia and its mucoadhesion potential have attracted many researchers. The mild preparation conditions of CS nanosystems offer the opportunities to load stress sensitive hydrophilic macromolecules such as proteins and genetic materials. Moreover CS nanosystems are able to protect their cargo from the environment (pH, enzy...
6 CitationsSource
#1Emanuela MartinoH-Index: 10
#2Francesco BraccoH-Index: 11
Last. Simona CollinaH-Index: 25
view all 10 authors...