Cong Yang
Guangzhou University of Chinese Medicine
NeprilysinPharmacokineticsGene silencingInternal medicineDownregulation and upregulationEndocrinologyGenetically modified mouseGlycationCellNeuroscienceReceptorChemistryTraditional Chinese medicineApoptosisTUNEL assayCholine acetyltransferaseNeuroprotectionSuperoxide dismutaseOxidative stressNeurodegenerationMalondialdehydeMPTPAcetylcholinesteraseDiseaseDementiaHerbMicrogliaAmyloidosisHippocampusProgrammed cell deathMorris water navigation taskActive ingredientReactive oxygen speciesAlzheimer's diseaseCancer researchTraditional medicineMedicineBiologyNeuroinflammationPharmacology
23Publications
12H-index
333Citations
Publications 22
Newest
#1Yousheng Mo (Guangzhou University of Chinese Medicine)H-Index: 7
#2Lining Duan (Guangzhou University of Chinese Medicine)
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
view all 15 authors...
Intracerebral hemorrhage (ICH) is a neurological disorder resulting from the nontraumatic rupture of blood vessels in the brain. Ferroptosis is a newly identified form of programmed cell death, which is an important pathological feature of ICH injury. At present, the therapeutic efficacy of ICH treatment is far from satisfactory, so it is urgent to develop a safer and more effective method to treat ICH injury. Resveratrol (Res), a widely used nonflavonoid polyphenol compound, plays a neuroprotec...
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#1Xian-Hua Chen (Guangzhou University of Chinese Medicine)
#2Cong Yang (Guangzhou University of Chinese Medicine)H-Index: 12
Last. Qi Wang (Guangzhou University of Chinese Medicine)H-Index: 24
view all 4 authors...
A new flavonoid named (2S)-7,4′-dimethoxyl-6-(2″,3″-epoxy-3″-methylbutyl)flavanone (1), along with five known compounds (2–6), were isolated from the EtOAc-soluble extract of the stem bark of Maack...
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#1Lei SongH-Index: 4
#2Yi Luo (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Cong YangH-Index: 12
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Aims Isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, has previously been reported to have anti-tumor effects in vivo and in vitro. However, the mechanisms whereby ISL exerts its anticancer effects remain poorly understood in hepatocellular carcinoma (HCC). Purpose In the present study, we investigated the anticancer efficacy and associated mechanisms of ISL in HCC MHCC97-H and SMMC7721 cells. Results We found that ISL inhibited cell viability and proliferation and induced apoptosis...
1 CitationsSource
#1Haobin Cai (Guangzhou University of Chinese Medicine)H-Index: 5
#2Tiantian Cai (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Qi Wang (Guangzhou University of Chinese Medicine)H-Index: 24
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Objective Effective drugs for treating dementia are still rare. Danggui-Shaoyao San(DSS), a traditional Chinese medicine, has been widely used in oriental countries for the treatment of various gyn...
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#1Yajing Huang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Cheng Zhou (SCUT: South China University of Technology)H-Index: 1
Last. Changjun Wang (Guangzhou University of Chinese Medicine)H-Index: 1
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The traditional Chinese medicine formula Jianpi-Huayu (JPHY) has been reported to be effective in the treatment of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear....
1 CitationsSource
#1Cong Yang (Guangzhou University of Chinese Medicine)H-Index: 12
#2Yousheng Mo (Guangzhou University of Chinese Medicine)H-Index: 7
Last. Qi Wang (Guangzhou University of Chinese Medicine)H-Index: 24
view all 14 authors...
Abstract Oxidative stress and neuroinflammation are the key and early events during the pathological process of Parkinson's disease (PD). Thus, therapeutic intervention to regulate oxidative stress and neuroinflammation would be an effective strategy to alleviate the progression of PD. Astragaloside IV, the main active component isolated from Astragalus membranaceus, has been shown to possess anti-inflammatory and anti-oxidant properties in neurodegeneration diseases, however, the molecular mech...
16 CitationsSource
#1Yunxia Luo (Guangzhou University of Chinese Medicine)H-Index: 4
#2Xin-Yue Wang (SYSU: Sun Yat-sen University)H-Index: 4
Last. Jiansong Fang (Guangzhou University of Chinese Medicine)H-Index: 20
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Abstract Liver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang Prescription (SWGJP), derived from traditional Chinese medicine (TCM), has shown its effectiveness in long-term liver damage therapy, although the underlying molecular mechanisms are still not fully understood. To explore the underlining mechanisms of ac...
1 CitationsSource
#1Yousheng Mo (Guangzhou University of Chinese Medicine)H-Index: 7
#2Erjin Xu (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Qi Wang (Guangzhou University of Chinese Medicine)H-Index: 24
view all 12 authors...
Parkinson’s disease (PD), the second most common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Although the molecular mechanisms underlying dopaminergic neuronal degeneration in PD remain unclear, neuroinflammation is considered as the vital mediator in the pathogenesis and progression of PD. Bushen-Yizhi Formula (BSYZ), a traditional Chinese medicine, has been demonstrated to exert antineuroinflammation in our previous studi...
6 CitationsSource
#1Yi-Jun Xu (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yu Mei (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Yongbin Zhang (Guangzhou University of Chinese Medicine)H-Index: 7
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Ligustilide, the main lipophilic component of Radix angelicae sinensis, has been shown to ameliorate cognitive dysfunction in a few Alzheimer’s disease mouse models, but its mechanism is not fully understood. In this study, we employed 7-month-old APP/PS1 mice to explore whether LIG is able to protect against Alzheimer’s disease progression. The Morris water maze and Y-maze test results showed that eight weeks of intragastric administration of LIG (10 mg/kg, 40 mg/kg) every day improved memory d...
17 CitationsSource
#1Mao Huang (SYSU: Sun Yat-sen University)H-Index: 4
#2Weiwei Qi (SYSU: Sun Yat-sen University)H-Index: 10
Last. Guoquan Gao (SYSU: Sun Yat-sen University)H-Index: 23
view all 15 authors...
Alzheimer’s disease (AD) is the most common cause of dementia. Pigment epithelium-derived factor (PEDF), a unique neurotrophic protein, decreases with aging. Previous reports have conflicted regarding whether the PEDF concentration is altered in AD patients. In addition, the effect of PEDF on AD has not been documented. Here, we tested serum samples of 31 AD patients and 271 normal controls. We found that compared to PEDF levels in young and middle-aged control subjects, PEDF levels were reduced...
6 CitationsSource