Abhijit J. Chaudhari
University of California, Davis
Avalanche photodiodeOpticsPhysicsRadiologyPET-CTPathologyMagnetic resonance imagingArtificial intelligenceImage warpingPositron emission tomographyInflammatory arthritisArthritisRheumatoid arthritisWristScannerPreclinical imagingNuclear medicineHigh resolutionComputer visionComputer scienceMedicineDetector
81Publications
18H-index
1,039Citations
Publications 79
Newest
We explore two depth of interaction (DOI) capable detectors with a high effective packing fraction to be used for the PET portion of a next generation cylindrical pendant breast PET/CT scanner. The proposed dual-readout detectors consist of an unpolished (14 14) array of LSO crystals coupled to a position sensitive-PMT (PSPMT) at the back end for position sensing and either (A) a (2 2) matrix of avalanche photodiodes (APDs) or (B) a single large APD at the front end for measuring DOI. Increased ...
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#1Spencer L. BowenH-Index: 11
Last. Ramsey D. BadawiH-Index: 29
view all 10 authors...
#2George W. BurkettH-Index: 10
Last. Ramsey D. BadawiH-Index: 29
view all 10 authors...
#1Joyita Dutta (SC: University of Southern California)H-Index: 14
#2Sangtae Ahn (SC: University of Southern California)H-Index: 23
Last. Richard M. Leahy (SC: University of Southern California)H-Index: 75
view all 6 authors...
The forward problem of optical bioluminescence and fluorescence tomography seeks to determine, for a given 3D source distribution, the photon density on the surface of an animal. Photon transport through tissues is commonly modeled by the diffusion equation. The challenge, then, is to accurately and efficiently solve the diffusion equation for a realistic animal geometry and heterogeneous tissue types. Fast analytical solvers are available that can be applied to arbitrary geometries but assume h...
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#1Sangtae Ahn (SC: University of Southern California)H-Index: 23
#2Abhijit J. Chaudhari (SC: University of Southern California)H-Index: 18
Last. Richard M. Leahy (SC: University of Southern California)H-Index: 75
view all 5 authors...
We investigate fast iterative image reconstruction methods for fully 3D multispectral optical bioluminescence tomography where inhomogeneous optical properties are modeled using the finite element method (FEM). We compare two approaches to incorporating the forward model into the solution of the inverse problem. In the direct calculation approach we compute the full forward model by repeated solution of the PEM problem, once for each potential source location. In the on-the-fly approach, we do n...
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#1Abhijit J. Chaudhari (SC: University of Southern California)H-Index: 18
#2Anand A. Joshi (SC: University of Southern California)H-Index: 24
Last. Richard M. Leahy (SC: University of Southern California)H-Index: 75
view all 4 authors...
Atlases are normalized representations of anatomy that can provide a standard coordinate system for in vivo imaging studies. For Optical Bioluminescence Tomography (OBT) in small animals, the animal's surface topography can be reconstructed from structured light measurements, but internal anatomy is unavailable unless additional CT or MR images are acquired. We present a novel method for estimating the internal organ structure of a mouse by warping a labeled 3D volumetric mouse atlas with the co...
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#1Abhijit J. Chaudhari (SC: University of Southern California)H-Index: 18
#2Felix Darvas (SC: University of Southern California)H-Index: 22
Last. Richard M. Leahy (SC: University of Southern California)H-Index: 75
view all 8 authors...
For bioluminescence imaging studies in small animals, it is important to be able to accurately localize the three-dimensional (3D) distribution of the underlying bioluminescent source. The spectrum of light produced by the source that escapes the subject varies with the depth of the emission source because of the wavelength-dependence of the optical properties of tissue. Consequently, multispectral or hyperspectral data acquisition should help in the 3D localization of deep sources. In this pape...
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#1Ram P. Singh (UCLA: University of California, Los Angeles)H-Index: 16
#2Vanessa M. Brown (UCLA: University of California, Los Angeles)H-Index: 4
Last. Desmond J. Smith (UCLA: University of California, Los Angeles)H-Index: 35
view all 10 authors...
Voxelation allows high-throughput acquisition of multiple volumetric images of brain gene expression, similar to those obtained from biomedical imaging systems. To obtain these images, the method employs analysis of spatially registered voxels (cubes). For creation of high-resolution maps using voxelation, relatively small voxel sizes are necessary and instruments will be required for semiautomated harvesting of such voxels. Here, we describe two devices that allow spatially registered harvestin...
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#1Ram P. Singh (UCLA: University of California, Los Angeles)H-Index: 16
#2Dahai Liu (UCLA: University of California, Los Angeles)H-Index: 4
Last. Desmond J. Smith (UCLA: University of California, Los Angeles)H-Index: 35
view all 6 authors...
Voxelation is a new approach for genome scale acquisition of brain gene expression patterns. The method employs high-throughput analysis of spatially registered voxels (cubes) to create multiple volumetric images of brain gene expression, similar to those obtained from biomedical imaging systems. The spatial resolution of voxelation depends on voxel size, with smaller voxels giving higher resolution. An important question is the applicability of different transcript profiling tools for the vario...
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