Jin-Hoi Kim
Konkuk University
TransgeneGeneCytotoxicityInternal medicineGene expressionMolecular biologyAndrologyNanotechnologyChemistryApoptosisMaterials scienceEmbryoSomatic cell nuclear transferImmunologyStem cellReactive oxygen speciesViability assayGeneticsBiologyCell biology
322Publications
60H-index
7,790Citations
Publications 310
Newest
Extracellular vesicles (EVs) are a heterogeneous group of membrane-limited vesicles and multi-signal messengers loaded with biomolecules. Exosomes and ectosomes are two different types of EVs generated by all cell types. Their formation depends on local microdomains assembled in endocytic membranes for exosomes and in the plasma membrane for ectosomes. Further, EV release is a fundamental process required for intercellular communication in both normal physiology and pathological conditions to tr...
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The efficiency of existing cell lysis methods to isolate nucleic acids from diverse bacteria varies depending on cell wall structures. This study tested a novel idea of using broad-spectrum antimicrobial peptides to improve the lytic efficiency of hard-to-lyse bacteria and characterized their differences. The lysis conditions of Staphylococcus aureus using recombinant porcine myeloid antimicrobial peptide 36 (PMAP-36), a broad-spectrum pig cathelicidin, was optimized, and RNA isolation was perfo...
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#1Sangiliyandi Gurunathan (Konkuk University)H-Index: 60
#2Min-Hee Kang (Konkuk University)H-Index: 14
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
view all 4 authors...
Background Exosomes are endosome-derived nano-sized vesicles that have emerged as important mediators of intercellular communication and play significant roles in various diseases. However, their applications are rigorously restricted by the limited secretion competence of cells. Therefore, strategies to enhance the production and functions of exosomes are warranted. Studies have shown that nanomaterials can significantly enhance the effects of cells and exosomes in intercellular communication; ...
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#1Hansam ChoH-Index: 6
#2Yuyeon Jang (Konkuk University)H-Index: 3
Last. Young Bong Kim (Konkuk University)H-Index: 19
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Here we report a recombinant baculoviral vector-based DNA vaccine system against Middle East respiratory syndrome coronavirus (MERS-CoV) and the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2). A non-replicating recombinant baculovirus expressing the human endogenous retrovirus envelope gene (AcHERV) was constructed as a DNA vaccine vector for gene delivery into human cells. For MERS-CoV vaccine construction, DNA encoding MERS-CoV S-full, S1 subunit, or receptor-binding domain (RBD) ...
1 CitationsSource
#2Muhammad QasimH-Index: 49
Last. Jin-Hoi KimH-Index: 60
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Cancer is a large group of diseases and the second leading cause of death worldwide. Lung, prostate, colorectal, stomach, and liver cancers are the most common types of cancer in men, whereas breast, colorectal, lung, cervical, and thyroid cancers are the most common among women. Presently, various treatment strategies, including surgical resection combined with chemotherapy, radiotherapy, nanotherapy, and immunotherapy, have been used as conventional treatments for patients with cancer. However...
1 CitationsSource
#1Sangiliyandi Gurunathan (Konkuk University)H-Index: 6
Last. Jin-Hoi KimH-Index: 60
view all 5 authors...
Note: In lieu of an abstract, this is an excerpt from the first page. In the original review
1 CitationsSource
#1Sangiliyandi Gurunathan (Konkuk University)H-Index: 60
#2Min-Hee Kang (Konkuk University)H-Index: 14
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
view all 3 authors...
Exosomes are nanoscale-sized membrane vesicles secreted by almost all cell types into the extracellular environment upon fusion of multivesicular bodies and plasma membrane. Biogenesis of exosomes is a protein quality control mechanism, and once released, exosomes transmit signals to other cells. The applications of exosomes have increased immensely in biomedical fields owing to their cell-specific cargos that facilitate intercellular communications with neighboring cells through the transfer of...
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#1Soundrarajan Nagasundarapandian (Konkuk University)
#2Hye-sun Cho (Konkuk University)H-Index: 7
Last. Chankyu Park (Konkuk University)H-Index: 52
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The effects of ΔPb-CATH4, a cathelicidin derived from Python bivittatus, were evaluated against Staphylococcus aureus-infected wounds in mice. These effects were comparable to those of classical antibiotics. ΔPb-CATH4 was resistant to bacterial protease but not to porcine trypsin. A reduction in the level of inflammatory cytokines and an increase in the migration of immune cells was observed in vitro. Thus, ΔPb-CATH4 can promote wound healing by controlling infections including those caused by m...
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#1Min Kyeung Choi (Konkuk University)H-Index: 1
#1Min-Kyeung Choi (Konkuk University)H-Index: 8
Last. Chankyu Park (Konkuk University)H-Index: 52
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Antimicrobial peptides (AMPs) are of interest as alternatives to antibiotics or immunomodulators. We generated and characterized the phenotypes of transgenic mice overexpressing protegrin 1 (PG1), a potent porcine cathelicidin. No obvious differences were observed between PG1 transgenic and wild-type mice in terms of growth, development, general behaviour, and the major immune cell population. However, PG1 transgenic mice intranasally infected with Staphylococcus aureus resulted in a reduction i...
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#1Mingue Kang (Konkuk University)H-Index: 2
#2Byeongyong Ahn (Konkuk University)H-Index: 4
Last. Chankyu Park (Konkuk University)H-Index: 52
view all 9 authors...
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