Zhiwu Zhang
Washington State University
Best linear unbiased predictionGeneGenome-wide association studyTraitData miningAssociation mappingGenomeSingle-nucleotide polymorphismHeritabilityNested association mappingAlleleGenetic associationGermplasmHip dysplasia (canine)PopulationGenotypingLinkage disequilibriumComputer scienceGeneticsGenetic variationCandidate geneComputational biologyMedicineQuantitative trait locusBiologyGenetic architecture
117Publications
37H-index
12.9kCitations
Publications 113
Newest
#1McGowan M (WSU: Washington State University)H-Index: 1
#2Zhiwu Zhang (WSU: Washington State University)H-Index: 37
Last. Stephen P. Ficklin (WSU: Washington State University)H-Index: 19
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BACKGROUND Gene expression is potentially an important heritable quantitative trait that mediates between genetic variation and higher-level complex phenotypes through time and condition-dependent regulatory interactions. Therefore, we sought to explore both the genomic and condition-specific characteristics of gene expression heritability within the context of chromosomal structure. RESULTS Heritability was estimated for biological gene expression using a diverse, 84-line, Oryza sativa (rice) p...
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#1Ying Wu (WSU: Washington State University)H-Index: 12
#2Fan LinH-Index: 6
Last. Bao Liu (Ministry of Education)H-Index: 56
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2 CitationsSource
#1Fan Zhang (WSU: Washington State University)H-Index: 37
#2Junmei KangH-Index: 14
Last. Qing X. YangH-Index: 35
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Fall dormancy (FD) is one of the most important traits of alfalfa (Medicago sativa) for cultivar selection to overcome winter stress. Although transcriptomics, proteomics analysis, and QTL mapping have revealed some important genes correlated with FD, the genetic architecture of this trait is still unclear. There are no applicable genes or markers for selection, which hinders progress in the genetic research and molecular breeding for the trait. We conducted whole-genome sequencing (WGS) on 220 ...
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#1Kelly Swarts (Austrian Academy of Sciences)H-Index: 8
#2Eva Bauer (TUM: Technische Universität München)H-Index: 37
Last. Peter J. Bradbury (ARS: Agricultural Research Service)H-Index: 34
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Domesticates are an excellent model for understanding biological consequences of rapid climate change. Maize (Zea mays ssp. mays) was domesticated from a tropical grass yet is widespread across temperate regions today. We investigate the biological basis of temperate adaptation in diverse structured nested association mapping (NAM) populations from China, Europe (Dent and Flint) and the United States as well as in the Ames inbred diversity panel, using days to flowering as a proxy. Using cross-p...
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#1Zhiwu ZhangH-Index: 37
Last. Ben J. HayesH-Index: 83
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#1Laura E. Tibbs Cortes (Iowa State University)H-Index: 2
#2Zhiwu Zhang (WSU: Washington State University)H-Index: 1
Last. Jianming Yu (Iowa State University)H-Index: 49
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Genome-wide association studies (GWAS) have developed into a powerful and ubiquitous tool for the investigation of complex traits. In large part, this was fueled by advances in genomic technology, enabling us to examine genome-wide genetic variants across diverse genetic materials. The development of the mixed model framework for GWAS dramatically reduced the number of false positives compared with naive methods. Building on this foundation, many methods have since been developed to increase com...
3 CitationsSource
#1Ruicai LongH-Index: 1
#1Ruicai LongH-Index: 11
Last. Qingchuan YangH-Index: 5
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Alfalfa (Medicago sativa L.), the most valuable perennial legume crop, referred to as "Queen of the Forages" for its high nutritional value and yield production among forage crops. Comprehensive genomic information of germplasm resources from different ecological regions and modern breeding strategies, such as molecular-marker assisted breeding are of great importance to breed new alfalfa varieties with environmental resilience. Here, we report assembly of the genome sequence of Zhongmu-4 (ZM-4)...
1 CitationsSource
#1Zhou Tang (WSU: Washington State University)
#2Atit Parajuli (WSU: Washington State University)
Last. Long-Xi Yu (USDA: United States Department of Agriculture)
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Alfalfa is the most widely cultivated forage legume, with approximately 30 million hectares planted worldwide. Genetic improvements in alfalfa have been highly successful in developing cultivars with exceptional winter hardiness and disease resistance traits. However, genetic improvements have been limited for complex economically important traits such as biomass. One of the major bottlenecks is the labor-intensive phenotyping burden for biomass selection. In this study, we employed two alfalfa ...
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#1Matthew T McGowan (WSU: Washington State University)
#1McGowan M (WSU: Washington State University)H-Index: 1
Last. Stephen P. Ficklin (WSU: Washington State University)H-Index: 19
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Background Gene expression is potentially an important heritable quantitative trait that mediates between genetic variation and higher-level complex phenotypes through time and condition-dependent regulatory interactions. Increasing quantities of high-throughput DNA and RNA sequencing and standardization of research populations has resulted in the accumulation of overlapping -omics data allowing for deeper investigation into the genomic structure and conditional stability of gene expression trai...
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#1Karansher S. Sandhu (WSU: Washington State University)H-Index: 2
#2Dennis N. Lozada (NMSU: New Mexico State University)H-Index: 1
Last. Arron H. Carter (WSU: Washington State University)H-Index: 19
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Genomic selection (GS) is transforming the field of plant breeding and implementing models that improve prediction accuracy for complex traits is needed. Analytical methods for complex datasets traditionally used in other disciplines represent an opportunity for improving prediction accuracy in GS. Deep learning (DL) is a branch of machine learning which focuses on densely connected networks using artificial neural networks for training the models. The objective of this research was to evaluate ...
3 CitationsSource