Kohzoh Imai
University of Tokyo
GeneCancerPathologyAntigenMolecular biologyAntibodyDNA methylationImmunologyImmunohistochemistryMetastasisMethylationEpigeneticsCancer researchColorectal cancerMonoclonal antibodyCarcinogenesisMedicineBiologyGastroenterologyCancer cell
792Publications
87H-index
28kCitations
Publications 775
Newest
#1Kenzo Hiroshima (Chiba University)H-Index: 25
#2Di WuH-Index: 9
Last. Kohzoh Imai (UTokyo: University of Tokyo)H-Index: 87
view all 14 authors...
BACKGROUND: The specificity and sensitivity of HEG1 for malignant mesothelioma (MM) is high. The use of BAP1/MTAP immunohistochemistry (IHC) is recommended to separate benign and malignant mesothelial proliferations. We determined how ancillary techniques can be used for the cytological diagnosis of MM with effusion. METHODS: Cell blocks from effusions from cases with MM, reactive mesothelial cells (RMCs), and carcinomas were analyzed by IHC with HEG1, BAP1, and MTAP and with homozygous deletion...
5 CitationsSource
#1Hiroyuki Yamamoto (St. Marianna University School of Medicine)H-Index: 67
#2Yoshiyuki Watanabe (St. Marianna University School of Medicine)H-Index: 19
Last. Fumio Itoh (St. Marianna University School of Medicine)H-Index: 30
view all 5 authors...
Defective DNA mismatch repair creates a strong mutator phenotype, recognized as microsatellite instability (MSI). Various next-generation sequencing-based methods for evaluating cancer MSI status have been established, and NGS-based studies have thoroughly described MSI-driven tumorigenesis. Accordingly, high-frequency MSI (MSI-H) has been detected in 81 tumor types, including those in which MSI was previously underrated. The findings have increased the use of immunotherapy, which is assumed to ...
Source
#1Hisayoshi Igarashi (Sapporo Medical University)H-Index: 11
#2Hiroaki Taniguchi (UTokyo: University of Tokyo)H-Index: 22
Last. Hiroshi Nakase (Sapporo Medical University)H-Index: 37
view all 10 authors...
Background Emerging evidence suggests that stemness in cancer cells is a cause of drug resistance or metastasis and is an important therapeutic target. PR [positive regulatory domain I-binding factor 1 (PRDI-BF1) and retinoblastoma protein-interacting zinc finger gene (RIZ1)] domain containing 14 (PRDM14), that regulates pluripotency in primordial germ cell, has reported the overexpression and function of stemness in various malignancies, suggesting it as the possible therapeutic target. However...
1 CitationsSource
#1Hiroaki Shima (Sapporo Medical University)H-Index: 8
#2Giichiro Tsurita (UTokyo: University of Tokyo)H-Index: 13
Last. Toshihiko Torigoe (Sapporo Medical University)H-Index: 47
view all 27 authors...
: The prognosis of advanced pancreatic adenocarcinoma is still extremely poor. This study sought to determine the efficacy of, and immunological response to, peptide vaccination therapy in patients with this disease. In this multicenter randomized phase II study, patients with advanced pancreatic adenocarcinoma after gemcitabine and/or tegafur/gimeracil/oteracil were randomly assigned to 3 groups that each received a 2-step treatment course. In Step 1, the groups received treatments of: (i) surv...
17 CitationsSource
#1Terufumi Kubo (Sapporo Medical University)H-Index: 14
#2Giichiro Tsurita (UTokyo: University of Tokyo)H-Index: 13
Last. Toshihiko Torigoe (Sapporo Medical University)H-Index: 47
view all 20 authors...
: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer by providing new options in addition to existing therapies. However, peptide vaccination therapies still represent an attractive approach, because of the antigen specificity. We identified survivin 2B peptide (SVN-2B), a 9-mer antigenic peptide encoded by survivin, and an SVN-2B peptide vaccine-based phase II randomized clinical trial targeting unresectable and refractory pancreatic carcinoma was undertaken. The SV...
1 CitationsSource
#1Hiroyuki Yamamoto (St. Marianna University School of Medicine)H-Index: 67
#2Kohzoh Imai (UTokyo: University of Tokyo)H-Index: 87
Abstract Deficient DNA mismatch repair causes a robust mutator phenotype known as microsatellite instability (MSI). MSI is a feature of Lynch syndrome-related cancers and is also found in approximately 15% of sporadic gastric, colorectal, and endometrial cancers. Epigenetic inactivation of the MLH1 gene is often associated with sporadic MSI cancers. Recent next-generation sequencing (NGS)-based analyses have comprehensively characterized MSI-positive (MSI+) cancers, and several approaches for de...
8 CitationsSource
#1Hiroaki Taniguchi (Keio: Keio University)H-Index: 1
#2Kohzoh Imai (UTokyo: University of Tokyo)H-Index: 87
: The PRDI-BF1 and RIZ (PR) domain zinc finger protein 14 (PRDM14) is upregulated in approximately 60% of breast cancers, some of which exhibit gene amplification. In contrast, PRDM14 is not expressed in normal, and differentiated tissues. PRDM14+ breast cancer cells are resistant to chemotherapy drugs, are tumorigenic, and metastasize to the lungs. It is commonly assumed that genes that are overexpressed in cancers, such as PRDM14, are effective targets for new therapies that specifically abrog...
1 CitationsSource
#1Chiharu Moriya (UTokyo: University of Tokyo)H-Index: 4
#2Kohzoh Imai (UTokyo: University of Tokyo)H-Index: 87
Last. Hiroaki Taniguchi (UTokyo: University of Tokyo)H-Index: 22
view all 3 authors...
: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer that is typically diagnosed at a later stage with metastases and is difficult to treat. Therefore, investigating the mechanism of PDAC initiation is important to aid early-stage cancer detection. PRDM14 is a transcription factor that maintains pluripotency in embryonic stem cells and is overexpressed in several cancers. We previously reported that PRDM14 is overexpressed and regulates cancer stem-like phenotypes in PDAC...
4 CitationsSource
#1Rieko MatsuuraH-Index: 2
#2Hiroyuki Kaji (AIST: National Institute of Advanced Industrial Science and Technology)H-Index: 24
Last. Shoutaro TsujiH-Index: 13
view all 9 authors...
The anti-mesothelioma mAb SKM9-2 recognizes the sialylated protein HEG homolog 1 (HEG1). HEG1 is a 400 kDa mucin-like membrane protein found on mesothelioma. SKM9-2 can detect mesothelioma more specifically and sensitively than other antibodies against current mesothelioma markers; therefore, SKM9-2 would be likely useful for the precise detection and diagnosis of malignant mesothelioma. In the present study, we investigated the epitope of SKM9-2. We analyzed the binding of SKM9-2 to truncated H...
6 CitationsSource
#1Chiharu Moriya (UTokyo: University of Tokyo)H-Index: 4
#2Hiroaki Taniguchi (UTokyo: University of Tokyo)H-Index: 22
Last. Kohzoh Imai (UTokyo: University of Tokyo)H-Index: 87
view all 6 authors...
PRDM14 is overexpressed in various cancers and can regulate cancer phenotype under certain conditions. Inhibiting PRDM14 expression in breast and pancreatic cancers has been reported to reduce cancer stem-like phenotypes, which are associated with aggressive tumor properties. Therefore, PRDM14 is considered a promising target for cancer therapy. To develop a pharmaceutical treatment, the mechanism and interacting partners of PRDM14 need to be clarified. Here, we identified the proteins interacti...
6 CitationsSource