C. Bianchi
CancerInternal medicineRadiologySurgeryOncologyEffective dose (radiation)Odds ratioProspective cohort studyProstateFecal incontinenceHemorrhoidsAbdominal surgeryProstate cancerRectumPopulationToxicityNuclear medicineNomogramRadiation therapyMedicineGastroenterology
34Publications
10H-index
726Citations
Publications 34
Newest
#1Mauro CarraraH-Index: 16
#2S. TomatisH-Index: 1
Last. R. ValdagniH-Index: 4
view all 10 authors...
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#1Riccardo ValdagniH-Index: 51
#2Vittorio VavassoriH-Index: 18
Last. C. Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 7
view all 13 authors...
Purpose: To evaluate and discuss the role of specific types of abdominal surgery (SURG) before radical radiation therapy as a risk factor for late rectal toxicity in prostate cancer patients. Methods: Results concerning questionnaire-based scored late bleeding and faecal incontinence in 718 patients with a complete follow-up of 36 months were analysed, focusing on the impact of specific pre-radiotherapy abdominal/pelvic surgery procedures. Patients were accrued in the prospective study AIROPROS ...
28 CitationsSource
#1Riccardo ValdagniH-Index: 51
#2Michael W. Kattan (Cleveland Clinic Lerner College of Medicine)H-Index: 10
Last. Claudio Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 54
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Purpose Development of user-friendly tools for the prediction of single-patient probability of late rectal toxicity after conformal radiotherapy for prostate cancer. Methods and Materials This multicenter protocol was characterized by the prospective evaluation of rectal toxicity through self-assessed questionnaires (minimum follow-up, 36 months) by 718 adult men in the AIROPROS 0102 trial. Doses were between 70 and 80 Gy. Nomograms were created based on multivariable logistic regression analysi...
38 CitationsSource
#1S. TomatisH-Index: 13
#2Tiziana RancatiH-Index: 27
Last. Riccardo ValdagniH-Index: 51
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The aim of this study was to develop a model exploiting artificial neural networks (ANNs) to correlate dosimetric and clinical variables with late rectal bleeding in prostate cancer patients undergoing radical radiotherapy and to compare the ANN results with those of a standard logistic regression (LR) analysis. 718 men included in the AIROPROS 0102 trial were analyzed. This multicenter protocol was characterized by the prospective evaluation of rectal toxicity, with a minimum follow-up of 36 mo...
32 CitationsSource
4 CitationsSource
#1Gianni FellinH-Index: 17
#2Claudio Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 54
Last. Riccardo ValdagniH-Index: 51
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Abstract Purpose Assessing the predictors of late rectal toxicity after high-dose conformal radiotherapy for prostate cancer. Methods One thousand one hundred thirty-two patients entered a prospective observational multicentric study; late rectal toxicity was evaluated by a self-reported questionnaire. Results concerning bleeding and faecal incontinence of 718/1132 patients with a complete follow-up at 36 months were analysed. The correlation between a number of clinical–dosimetric parameters an...
96 CitationsSource
Purpose To predict acute Radiation Therapy Oncology Group (RTOG)/European Organization for Research and Treatment of Cancer (EORTC) and Subjective Objective Signs Management and Analysis/Late Effect of Normal Tissue (SOMA/LENT) toxicities of the lower gastrointestinal (LGI) syndrome in patients with prostate cancer undergoing three-dimensional conformal radiotherapy using a tool (nomogram) that takes into account clinical and dosimetric variables that proved to be significant in the Italian Asso...
86 CitationsSource
#1C. Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 7
#1Claudio Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 54
Last. Riccardo ValdagniH-Index: 51
view all 11 authors...
Purpose To assess the predictors of late rectal toxicity in a prospectively investigated group of patients treated at 70–80 Gy for prostate cancer (1.8–2 Gy fractions) with three-dimensional conformal radiotherapy. Methods and Materials A total of 1,132 patients were entered into the study between 2002 and 2004. Three types of rectal toxicity, evaluated by a self-administered questionnaire, mainly based on the subjective objective management, analytic late effects of normal tissue system, were c...
191 CitationsSource
Source
#1V. VavassoriH-Index: 7
#2Riccardo ValdagniH-Index: 51
Last. C. Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 7
view all 10 authors...
Results: 30/510 (5.9%) G2-G3 lrb were registered: in MVA V70 was the most significant dosimetric predictor of lrb (OR = 1.025, p = 0.03) together with SURG (OR = 2.5, p = 0.06). 14/510 (2.7%) pts were scored as G3 lrb: in MVA SURG (OR = 4.2, p = 0.02) was the main predictor while V75 (OR = 1.037, p = 0.13) and svRT (OR = 5.52, p = 0.11) were of borderline significance. In a further analysis on the subgroup of pts previously submitted to SURG (6 G2-G3 lrb) V70 was found to be strongly correlated ...
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