Ido Laish
Sheba Medical Center
EpidemiologyCancerTelomerase reverse transcriptaseInternal medicineOncologyCase-control studyAndrologyRetrospective cohort studyTelomereLynch syndromeInflammationPlacentaAdenomaFluorescence in situ hybridizationInflammatory bowel diseaseColonoscopyMSH2Crohn's diseaseAneuploidyOvarian cancerUlcerative colitisPolypectomyGenetic testingPopulationTelomere HomeostasisIn patientSurveillance colonoscopyIncidence (epidemiology)Cancer researchColorectal cancerBreast cancerDiabetes mellitusSyndecan 1MedicineCohortBiomarker (medicine)BiologyGastroenterology
Publications 23
#1Ido Laish (TAU: Tel Aviv University)H-Index: 7
#2Yael Goldberg (Rabin Medical Center)H-Index: 17
Last. Gili Levi-Reznick (Rambam Health Care Campus)
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Abstract null null Background null Routine screening for establishing Lynch syndrome (LS) in young individuals diagnosed with adenomas is not recommended due to its low yield, and limited sensitivity of the employment of immunohistochemistry for DNA mismatch-repair proteins on polyps. Hence we aimed to evaluate the yield of germline mutational analysis in diagnosis of LS in a young Israeli cohort with colorectal adenomatous polyps. null null null Methods null Data were retrospectively collected ...
#1Ido Laish (TAU: Tel Aviv University)H-Index: 7
#1Ido Laish (Sheba Medical Center)H-Index: 1
Last. Yael Goldberg (Rabin Medical Center)H-Index: 17
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BACKGROUND Hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS), the most common inherited cancer syndromes, are attributed to a single heterozygous pathogenic variant (PV) in BRCA1/2 or in a DNA MMR gene, respectively. Little is known about the phenotype in double heterozygotes who carry PVs in both genes. METHODS Carriers of double-PVs in any DNA MMR gene and BRCA1/2 attending one of three tertiary oncogenetic clinics between 1/2005 and 1/2020 were identified by databas...
#1Sapir Kon Kfir (Sheba Medical Center)
#2Reut Halperin (Sheba Medical Center)H-Index: 1
Last. Amit Tirosh (TAU: Tel Aviv University)H-Index: 16
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Pancreatic neuroendocrine tumors (PNET) may develop sporadically or in the context of hereditary syndromes. In patients with multiple endocrine neoplasia type 1 (MEN1), PNET is the leading cause of death. Our aim was to compare the mortality risk in sporadic and MEN1-related PNETs and identify high-risk populations. A retrospective Surveillance, Epidemiology, and End Results database analysis of patients with PNET was used. Patients with MEN1 were defined by syn/metachronous pituitary adenoma. C...
#1Inbal Kedar (Rabin Medical Center)H-Index: 8
#2L Walsh (UW: University of Washington)
Last. Yael Goldberg (Rabin Medical Center)H-Index: 17
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Lynch syndrome is an inherited cancer predisposition syndrome caused by germline defects in any of the mismatch repair (MMR) genes. Diagnosis of carriers makes precision prevention, early detection, and tailored treatment possible. Herein we report a novel founder deletion of 18,758 bp, mediated by Alu repeats on both sides, detected in Ethiopian Jews. The deletion, which encompasses exon 9-10 of the MSH2 coding sequence, is associated mainly with early-onset MSH2/MSH6-deficient colorectal cance...
1 CitationsSource
#1Oshrat Levi-Galibov (Weizmann Institute of Science)H-Index: 3
#2Hagar Lavon (Weizmann Institute of Science)H-Index: 3
Last. Ruth Scherz-Shouval (Weizmann Institute of Science)H-Index: 17
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In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease. While the causal and clinical links are well established, molecular understanding of how chronic inflammation leads to the development of colon cancer is lacking. Here we deconstruct the evolving microenvironment of CAC by measuring proteomic changes and extracellular matrix (ECM) organization over time in a mouse model of CAC. We detect early changes...
9 CitationsSource
#1Rinat Bernstein-Molho (TAU: Tel Aviv University)H-Index: 5
#1Rinat Bernstein-Molho (Sheba Medical Center)H-Index: 2
Last. Yael Goldberg (Rabin Medical Center)H-Index: 17
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BACKGROUND: Carriers of pathogenic variants (PVs) in moderate-high-penetrance cancer susceptibility genes are offered tailored surveillance schemes for early cancer diagnosis. The clinical implications of low-penetrance variant carriers are less clear. METHODS: Clinical and demographic data were retrieved for a cohort of Israeli individuals who underwent oncogenetic testing by the 30-gene cancer panel at Color Genomics laboratory, between 04/2013 and 12/2018. RESULTS: Of 758 genotyped individual...
1 CitationsSource
#1Ido Laish (TAU: Tel Aviv University)H-Index: 7
#2Lior H. Katz (TAU: Tel Aviv University)H-Index: 22
Last. Timna Naftali (TAU: Tel Aviv University)H-Index: 17
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Abstract Background and aims Few reports address the appropriate colonoscopy surveillance interval for individuals Methods This was a single center retrospective cohort study. Eligible subjects underwent their first colonoscopy with polypectomy between 2005 and 2014 and had at least one surveillance colonoscopy 3–5 years later. Patients (N = 495) were stratified at baseline into low-risk adenoma (LRA) and advanced adenoma groups. Study outcomes were overall and high-risk neoplasia at surveillanc...
2 CitationsSource
#1Ido Laish (Meir Medical Center)H-Index: 4
#1Ido Laish (TAU: Tel Aviv University)H-Index: 7
Last. Fred M. Konikoff (TAU: Tel Aviv University)H-Index: 25
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Summary Background and aims Current post-polypectomy surveillance interval guidelines do not discriminate between 1–2 diminutive (1–5 mm) and small (6–9 mm) non-advanced adenomas. This study compared the risk for metachronous advanced lesions in these groups. Methods Patients with 1–2 diminutive, non-advanced adenomas and no further advanced lesions, and patients with no polyps at baseline colonoscopy were retrospectively analyzed to determine the rate of metachronous advanced lesions. These wer...
6 CitationsSource
#1Timna Naftali (Meir Medical Center)H-Index: 17
#2Adi Eindor-Abarbanel (TAU: Tel Aviv University)H-Index: 2
Last. Efrat Broide (TAU: Tel Aviv University)H-Index: 23
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Background & Aims: Sense of coherence (SOC) is a theoretical concept reflecting a person‘s resources and orientation, which enable individuals to cope with stressors in a health-promoting manner. In several multifactorial chronic diseases, such as diabetes mellitus and systemic lupus erythematosus, SOC was correlated with disease development. It was also related with the emotional distress in patients with inflammatory boweldisease (IBD).The aim of this study was to investigate the possible corr...
#1Ido Laish (TAU: Tel Aviv University)H-Index: 7
#2Joseph Mizrahi (Stony Brook University Hospital)H-Index: 2
Last. Fred M. Konikoff (Meir Medical Center)H-Index: 25
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BACKGROUND AND AIMS: Interval colorectal cancer (CRC) is largely related to a poor endoscopic performance or different biology in the development of the polyp. However, patient-related factors were less investigated for their association with interval cancer. We thus evaluated tumor and patient characteristics as predictors of interval cancer in a population from Israel. METHODS: In this retrospective study, patients that were diagnosed with colon cancer in our institution and had 2 colonoscopie...
4 CitationsSource