Verónica Palma
University of Chile
Wharton's jellyInternal medicineDownregulation and upregulationNetrinEndocrinologyCellular differentiationNeuroscienceReceptorChemistryMesenchymal stem cellImmunologySonic hedgehogCyclopamineHedgehogAngiogenesisStem cellCancer researchGeneticsSignal transductionBiologyCell biology
59Publications
21H-index
2,715Citations
Publications 58
Newest
#1Ximena Vásquez (University of Chile)
#2Pilar Sánchez-Gómez (ISCIII: Carlos III Health Institute)H-Index: 14
Last. Verónica Palma (University of Chile)H-Index: 21
view all 3 authors...
Glioblastoma (GBM) is the most aggressive and common primary tumor of the central nervous system. It is characterized by having an infiltrating growth and by the presence of an excessive and aberrant vasculature. Some of the mechanisms that promote this neovascularization are angiogenesis and the transdifferentiation of tumor cells into endothelial cells or pericytes. In all these processes, the release of extracellular microvesicles by tumor cells plays an important role. Tumor cell-derived ext...
Source
#1Andrea A Villanueva (University of Chile)H-Index: 4
#2Pilar Sánchez-Gómez (ISCIII: Carlos III Health Institute)H-Index: 14
Last. Verónica Palma (University of Chile)H-Index: 21
view all 15 authors...
Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma. Here, we show that Netrin-1 ligand binding to Neogenin-1 leads to FAK autophosphorylation and integrin β1 activation in a FAK dependent manner, thus promoting neuroblastoma cell migration. Moreover, Neogenin-1, which was detected in all tumor stages and was required for n...
1 CitationsSource
#1Berta Segura-Collar (ISCIII: Carlos III Health Institute)H-Index: 5
#2María Garranzo-Asensio (ISCIII: Carlos III Health Institute)H-Index: 10
Last. Pilar Sánchez-Gómez (ISCIII: Carlos III Health Institute)H-Index: 14
view all 13 authors...
The extraordinary plasticity of glioma cells allows them to contribute to different cellular compartments in tumor vessels, reinforcing the vascular architecture. It was recently revealed that targeting glioma-derived pericytes, which represent a big percentage of the mural cell population in aggressive tumors, increases the permeability of the vessels and improves the efficiency of chemotherapy. However, the molecular determinants of this transdifferentiation process have not been elucidated. H...
1 CitationsSource
Last. Verónica PalmaH-Index: 21
view all 5 authors...
Source
#1Berta Segura-Collar (ISCIII: Carlos III Health Institute)H-Index: 5
#2María Garranzo-Asensio (ISCIII: Carlos III Health Institute)H-Index: 10
Last. Pilar Sánchez-Gómez (ISCIII: Carlos III Health Institute)H-Index: 14
view all 12 authors...
RationaleGlioma progression is driven by the induction of vascular alterations but how the tumor genotype influence these changes is still a pending issue. We propose to study the underlying mechanisms by which the genetic changes in isocitrate dehydrogenase 1/2 (IDH1/2) and epidermal growth factor receptor (EGFR) genes establish the different vascular profiles of gliomas. MethodsWe stratified gliomas based on the genetic status of IDH1/2 and EGFR genes. For that we used in silico data and a coh...
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#1Daniela Astudillo (University of Chile)H-Index: 1
#2Daniel Karmelic (University of Chile)H-Index: 1
Last. Magdalena Sanhueza (University of Chile)H-Index: 10
view all 6 authors...
CaMK2N1 and CaMK2N2 (also known as CaMKIINalpha and beta) are endogenous inhibitors of calcium/calmodulin-dependent kinase II (CaMKII), an enzyme critical for memory and long-term potentiation (LTP), a form of synaptic plasticity thought to underlie learning. CaMK2N1/2 mRNAs are rapidly and differentially upregulated in the hippocampus and amygdala after acquisition or retrieval of fear memory. Moreover, CaMK2N2 protein levels increase after contextual fear conditioning. Therefore, it was propos...
2 CitationsSource
#1Isaac Peña-Villalobos (University of Chile)H-Index: 8
#2Ignacio Casanova-Maldonado (University of Chile)H-Index: 2
Last. Pablo Sabat (University of Chile)H-Index: 25
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In order to maintain the energy balance, animals often exhibit several physiological adjustments when subjected to a decrease in resource availability. Specifically, some rodents show increases in behavioral activity in response to food restriction; a response regarded as a paradox because it would imply an investment in locomotor activity, despite the lack of trophic resources. Here, we aim to explore the possible existence of trade-offs between metabolic variables and behavioral responses when...
1 CitationsSource
Gestational diabetes mellitus (GDM) is a common metabolic disorder, defined by high blood glucose levels during pregnancy, which affects foetal and post-natal development. However, the cellular and molecular mechanisms of this detrimental condition are still poorly understood. A dysregulation in circulating angiogenic trophic factors, due to a dysfunction of the feto-placental unit, has been proposed to underlie GDM. But even the detailed study of canonical pro-angiogenic factors like vascular e...
2 CitationsSource
#1Isaac Peña-Villalobos (University of Chile)H-Index: 8
#2Ignacio Casanova-Maldonado (University of Chile)H-Index: 2
Last. Verónica Palma (University of Chile)H-Index: 21
view all 5 authors...
Several studies have evaluated plastic changes in the morphology of the digestive tract in rodents subjected to caloric restriction or restricted availability. Nevertheless, studies that link these morphological responses to physiological consequences are scarce. In order to investigate short-term plastic responses in the intestine, we acclimated adult Mus musculus (BALB/c) males for twenty days to four distinctive treatments: two caloric regimens (ad libitum and 60% of calorie ingestion) and tw...
4 CitationsSource
#1Andrea A Villanueva (University of Chile)H-Index: 4
#2Sofía Puvogel (University of Chile)H-Index: 1
Last. Verónica Palma (University of Chile)H-Index: 21
view all 12 authors...
ABSTRACTNeuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced ...
4 CitationsSource