Yili Qu
Sichuan University
Biomedical engineeringSoft tissueCellRegeneration (biology)ChemistryExtracellular matrixMaterials scienceMesenchymal stem cellDentistryIn vivoBarrier membraneMacrophageWound healingImplantBone regenerationMembraneViability assayMedicineScaffoldCell biology
50Publications
16H-index
594Citations
Publications 47
Newest
#1Chen Hu (Sichuan University)H-Index: 4
#2Chenyu Chu (Sichuan University)H-Index: 3
Last. Yi Man (Sichuan University)H-Index: 19
view all 10 authors...
The structural properties of biomaterials play crucial roles in guiding cell behavior and influencing immune responses against the material. We fabricated electrospun membranes with three types of surface topography (random, aligned, and latticed), introduced them to dorsal skin excisional wounds in mice and rats, and evaluated their effects on wound healing and immunomodulatory properties. An overview of different immune cells in the microenvironment with the help of single-cell RNA sequencing ...
Source
#1Chenyu Chu (Sichuan University)H-Index: 3
#2Shengan Rung (Sichuan University)H-Index: 3
Last. Yi Man (Sichuan University)H-Index: 19
view all 5 authors...
Source
#1Congrong WangH-Index: 27
#1Chenbing Wang (Sichuan University)H-Index: 1
Last. Yi ManH-Index: 19
view all 8 authors...
The re-epithelialization with appendages is a major challenge to skin injury. Given that topographical factors initially modulate cell activities, the design of biomaterials with the topography (such as pattern and diameter) offers a promising strategy for achieving optimal skin wound healing. Herein, we prepare an aligned fish collagen reinforced poly (lactide-co-glycolide) electrospinning membrane (FC/PLGA) with different fiber diameters for promoting the re-epithelialization with appendages. ...
Source
#1Chenyu Chu (Sichuan University)H-Index: 3
#2Shengan Rung (Sichuan University)H-Index: 3
Last. Yi Man (Sichuan University)H-Index: 19
view all 5 authors...
Culturing macrophage in vitro is an important means to understand its reaction towards co-culture substances. However, the source of macrophages can be either purchased from specific cell line or extracted from bone marrow as differentiated macrophages. In order to assure the precision, when adopting extracted primary cell, screening in advance will be prominent before any processes to avoid results reserving that of non-macrophages. Here, we perform single-cell sequencing on open wound of skin ...
Source
#1Chenyu ChuH-Index: 3
#2Shengan Rung (Sichuan University)H-Index: 3
Last. Yili QuH-Index: 16
view all 5 authors...
Abstract Though chemically cross-linked by EDC/NHS endows collagen membrane with promising mechanical properties, it is not conducive to modulation of foreign body reaction (FBR) after implantation or guidance of osteogenesis. In our previous research, we have found that macrophages have a strong regulatory effect on tissue and bone regeneration during FBR, and EGCG modified membranes could adjust the recruitment and phenotypes of macrophages. Accordingly, we develop the EGCG-EDC/NHS membranes, ...
Source
#1Chenyu ChuH-Index: 3
#2Shengan RungH-Index: 3
Last. Yili Qu (Sichuan University)H-Index: 16
view all 6 authors...
Culturing macrophage in vitro is an important means to understand its reaction towards co-culture substances. However, the source of macrophages can be either purchased from specific cell line or extracted from bone marrow as differentiated macrophages. In order to assure the precision, when adopting extracted primary cell, screening in advance will be prominent before any processes to avoid results reserving that of non-macrophages. Here, we perform single-cell sequencing on open wound of skin ...
Source
#1Chen Hu (Sichuan University)H-Index: 4
#2Chenyu Chu (Sichuan University)H-Index: 3
Last. Jidong Li (Sichuan University)H-Index: 18
view all 5 authors...
Structural properties of biomaterials play critical roles in guiding cell behaviors and influence the immune response against them. In this study, we fabricated electro-spun membranes with three types of surface topography (Random, Aligned, and Latticed). The aligned membranes showed immunomodulatory ability, and led to faster wound healing, reduced fibrotic response and enhanced regeneration of cutaneous appendages. Based on that, we performed single-cell RNA sequencing analysis on cells of wou...
1 CitationsSource
#1Chenyu ChuH-Index: 3
#2Chen Hu (Sichuan University)H-Index: 4
Last. Yi Man (Sichuan University)H-Index: 19
view all 6 authors...
Arginase 1 (ARG1), typically expressed under stress or stimulation rather than in the healthy condition in humans. However, more and more studies claim ARG1 could be expressed by human and represents healing process. Including THP-1 monocyte shift to M2 macrophages rendered a higher expression of ARG1 than that with bone-graft has an ideal effect on anti-inflammation, resulting in tissue healing. With the higher expression of ARG1 seemingly induced by the constructed material and represented by ...
Source
#1Shengnan Liao (Sichuan University)H-Index: 1
#2Yu TangH-Index: 1
Last. Yili Qu (Sichuan University)H-Index: 16
view all 7 authors...
Because of excellent biocompatibility, antioxidant activity, and anti-caries ability, EGCG has been widely studied in the treatment of oral diseases, such as periodontal disease, oral cancer, and dental caries. To reach the site of the lesion or achieve sustained release, play the role of anti-caries, anti-inflammatory, or to maintain or improve the physical properties of the modified materialEGCG need to be crosslinked or embedded with dental adhesives, barrier membranes, bone replacement mater...
5 CitationsSource
#1Yeyu Liu (Sichuan University)
#2Yilin Chen (Sichuan University)
Last. Yi Man (Sichuan University)H-Index: 19
view all 6 authors...
BACKGROUND: Conventional wisdom states that reactive soft tissue consisting of granulation tissue and long junctional epithelium in compromised sites should be curetted completely, while others approve of its preservation in implant surgeries. PURPOSE: To evaluate the presence of reactive soft tissue as wound closure for immediate implantation in posterior compromised sockets. MATERIALS AND METHODS: Thirty-three implants were included in this study: (a) experimental group (EG), the reactive soft...
Source